Block Symposia
Friday, May 6, 2022
Friday, May 6, 2022 2:00 PM – 4:00 PM Room A107–109
Antigen Processing and Presentation I
Chairs
- Laura Santambrogio, Weill Cornell Med.
- Malini Raghavan, Univ. of Michigan
Speakers
- Zhixin Jing, Albert Einstein Col. of Med., Germinal center expansion but not plasmablast differentiation is directly proportional to peptide-MHCII density via CD40-CD40L signaling strength
- Adam L. Burrack, Univ. of Minnesota, Distinct myeloid antigen presenting cells dictate differential fates of tumor-specific CD8 T cells in pancreatic cancer
- Laura Santambrogio, Weill Cornell Med., Metabolic insults elicit epitope-dependent immune autoreactivity aggravating hepatic damage in type 2 diabetes
- Padma Pandurang Nanaware, Univ. of Massachusetts Chan Med. Sch., Profiling MHC-I and MHC-II canonical and out-of-frame epitopes from SARS-CoV-2 and seasonal human coronavirus infected human cells
- Katheryn M. Wininger, Mayo Grad. Sch. of Biomed. Sci., Dissecting the role of H-2Db class I molecule in the development of brain atrophy during Theiler’s murine encephalomyelitis virus (TMEV) infection
- Jiansheng Jiang, NIAID, NIH, Mechanism of Peptide Loading as Revealed by Structure of tapasin/MHC-I Complex
- Julie Dobkin, Rutgers State Univ. of New Jersey, Investigating the potential binding partners of H2-O to further elucidate its role in MHCII antigen presentation
Friday, May 6, 2022 2:00 PM – 4:00 PM Room B117–119
HSCs and Myelopoiesis
Chairs
- Anna Beaudin, Sch. of Med., Univ. of Utah
- Jeffrey Bednarski, Washington Univ. Sch. of Med.
Speakers
- Stephanie Crowley, Washington Univ. Sch. of Med., Bclaf1 promotes hematopoietic stem cell repopulating capacity and self-renewal
- Momoko Yoshimoto, McGovern Med. School, Univ. of Texas Hlth. Sci. Ctr. at Houston, HSC-independent definitive lymphopoiesis persists into adult life
- Jennifer E. Howard, Albany Med. College, IL-18R signaling impairs hematopoietic recovery after severe, shock-like infection
- Marion Lacroix, IRCM, The X-linked gene for the helicase DDX3X is required for lymphoid differentiation and MYC-driven lymphomagenesis
- Betsabel J. Chicana, Sch. of Natural Sci., Univ. of California Merced, Vhl deficiency in Dmp1-expressing cells affects myeloid development and erythropoiesis: possible effects on myeloerythroid metabolism
- Tiantian Liu, Washington Univ. Sch. of Med. in St. Louis, Ablation of cDC2 lineage specification by mutations within the δ−165 kb Zeb2 enhancer
- Jayashree Srinivasan, Univ. of Texas at Austin, Cellular and molecular mediators of thymic DC homeostasis and activation
- Diego A. Lopez, Univ. of Utah Sch. of Med., Maternal immune activation (MIA) impairs neonatal lung ILC2 establishment, function, and airway hyperresponsiveness
Friday, May 6, 2022 2:00 PM – 4:00 PM Room B113–116
Immune-Based Therapeutics for Neurological Disease
Chairs
- Giorgio Raimondi, Johns Hopkins Univ. Sch. of Med.
- Andrea Castillo, Eastern Washington Univ.
Speakers
- Md Jahirul Islam, Seoul Natl. Univ. Col. of Med., Non-classical anti-inflammatory drugs (NCAIDs) ameliorates brain inflammation and improves memory in Alzheimer’s diseases mice model
- Jörg Wischhusen, Univ. Hosp. Wuerzburg, Alpha-synuclein peptides presented on chimeric MHC class Ib molecules prevent loss of substantia nigra neurons in an animal model for Parkinson's disease
- Kevin G. Senior, Univ. of Florida Col. of Med., Novel gene immunotherapy prevents Aquaporin-4 (AQP4) mediated neuroinflammation and demyelination in a mouse model of multiple sclerosis
- Weikan Wang, Univ. of North Texas Hlth. Sci. Ctr., Aging impairs regulatory T cell (Treg) cells to affect late-onset (aged) multiple sclerosis (MS) – with the model of experimental autoimmune encephalomyelitis (EAE)
- Daniel Hwang, Thomas Jefferson Univ., CSF-1 maintains pathogenic but not homeostatic myeloid cells in the central nervous system during autoimmune neuroinflammation
- Javier Ochoa-Reparaz, Eastern Washington Univ., A GABA-producing probiotic for the protection of CNS demyelinating inflammation
- Gaurav Kumar, Oklahoma Med. Res. Fndn., Deficiency in B Cell Maturation Antigen reveals sex differences in Experimental Autoimmune Encephalomyelitis
- Giorgio Raimondi, Johns Hopkins Univ. Sch. of Med., Tolerogenic Artificial Antigen Presenting Cells for Selective Tolerance in Autoimmune Disease
Friday, May 6, 2022 2:00 PM – 4:00 PM Room C123–124
Immunoregulation—General
Chairs
- Gudrun Debes, Thomas Jefferson Univ.
- Robert Lochhead, Med. Col. of Wisconsin
Speakers
- Neetu Gupta, Cleveland Clin., Myosin 18A is a novel checkpoint regulator in B cell differentiation and antibody-mediated immunity
- Shannon E. McGettigan, Thomas Jefferson Univ., Secreted IgM modulates the pool of IL-10producing B Cells
- Lance K. Blevins, Michigan State Univ., scRNA-Seq analysis of human CD5+ innate-like B cells identifies AHR expression as a marker of human CD9+ IL-10+ BRegulatory cells
- Jason M. Zimmerer, Wexner Med. Ctr., Ohio State Univ., Alloprimed antibody-suppressor CD8+ T cells preferentially kill alloprimed germinal center B cells
- Astrid E. Cardona, Univ. of Texas at San Antonio, Fibrinogen depletion ameliorates inflammation and vision loss in mouse models of diabetes
- Gautham S. Ramakrishnan, Univ. of Oklahoma Hlth. Sci. Ctr., SHIP-2 inhibits human microglia-like cell function in a TREM2 independent manner
- Dawit T.A. Mengistu, Univ. of Michigan, Tolerogenic markers on lung dendritic cells reversibly decrease following cigarette smoke exposure in mice
- Meihong Deng, Wexner Med. Ctr., Ohio State Univ., Activation of TLR9 signaling in fibroblastic reticular cells enhances anti-tumor immunity in peritoneal tumor via suppressing peritoneal resident macrophage retention
Friday, May 6, 2022 2:00 PM – 4:00 PM Room A105–106
Immunoregulation—Mechanism of Action
Chairs
- Rana Herro, Cincinnati Children's Hosp. Med. Ctr.
- Georges Helou, Univ. of Southern California
Speakers
- Marina Ninkov, Univ. of Western Ontario, Canada, Chronic stress results in intrahepatic accumulation of a mononuclear myeloid-derived suppressor cell-like population
- Temitayo Taiwo Bamgbose, Louisiana State Univ. Hlth. Sciences Ctr. at Shreveport, Lipin-1 restrains lipid synthesis to promote proresolving macrophage function and disease resolution
- Carlos Alberto Mier Aguilar, Univ. of Alabama at Birmingham, Triggering receptor expressed on myeloid cells (Trem)-1 plays important roles in UVB induced immune suppression and cutaneous carcinogenesis
- Pushpa Pandiyan, Case Western Reserve Univ., A new mechanism of Treg cell dysfunction during HIV infection and propensity to oral cancer in people living with HIV
- Mohammad Nizam Mansoori, NIAID, NIH, Tregs suppress antigen-specific CD8+ T cells in vivo by depleting pMHC-I complexes from dendritic cells
- Shaikh M. Atif, Univ. of Colorado Anschutz Med. Campus, Protective role of tissue-resident regulatory T cells in a murine model of beryllium-induced disease
- Shokofeh Rahimpour, West Virginia Univ., A potential monocyte-regulatory T cell axis in neurorestoration following ischemic stroke
Friday, May 6, 2022 2:00 PM – 4:00 PM Oregon Ballroom 202
Memory T Cell Differentiation, Function, and Maintenance
Chairs
- Nathan Schuldt, Univ. of Minnesota Med. Sch.
- Yina Huang, Geisel Sch. of Med., Dartmouth Col.
Speakers
- Terran D. Stenger, Univ. of Minnesota Med. Sch., Normal microbial experiences accelerate memory T cell compartment maturation in infants
- Verena van der Heide, Icahn Sch. of Med. at Mount Sinai, Helpless CD8 T cell memory explained: prolonged antigen presentation drives a temporal rather than terminal defect
- Taylor Heim, New York Univ. Langone Med. Ctr., CXCR6 is required for tissue resident memory T cell formation across diverse peripheral non-lymphoid tissues
- Asmaa Mohamed, Geisel Sch. of Med., Dartmouth Col., Dendritic cells instruct differentiation of tissue resident memory T cells in the skin to promote durable tumor immunity
- Henrique Borges da Silva, Mayo Clin., Cell-intrinsic expression of the hemichannel Pannexin-1 promotes effector and memory CD8+ T cells via distinct metabolic pathways
- Daniel P. Caron, Columbia Univ. Med. Ctr., Human T cells in barrier sites exhibit site-specific characteristics and clonal compartmentalization
- James R. Rose, Emory Univ. Sch. of Med., Epigenome accessibility changes before and after activation reveal distinct and progressive differentiation for human memory T cell subsets
Friday, May 6, 2022 2:00 PM – 4:00 PM Room B110–112
Pulmonary, Vasculature, and Skin Immunity
Chairs
- Estelle Cormet-Boyaka, Col. of Vet. Med., The Ohio State Univ.
- Erika Darrah, John Hopkins Med. Inst.
Speakers
- Young me Yoon, Univ. of Chicago, Interstitial lung disease patients exhibit augmented germinal center responses in lung lymph nodes and increased serum reactivities to novel autoantigens
- Anshu Agrawal, Univ. of California Irvine, Differential response of dendritic cells and macrophages to signals from airway epithelial cells in humans: changes with age
- Fatema Alrashed, Dasman Diabetes Inst., Candida albicans Induces Foaming and Inflammation in Macrophages through FABP4: Its Implication for Atherosclerosis
- David Cheng Yang, Univ. of California, Davis, Tobacco smoke activated fibrogenic MARCKS/AXL complex promotes macrophage reprogramming and pulmonary fibrosis
- Alexandre Cammarata-Mouchtouris, Emory Univ. Sch. of Med., Pathological metabolic adaptation of neutrophils recruited to cystic fibrosis airway microenvironment can not be reversed by modulator therapy
- Shuto Kanameishi, Kyoto Univ., Lymphotoxin &β receptor signaling mediates the formation of high endothelial venule-like vessels in atopic dermatitis-like skin lesions in mice
- Hyeung Ju Park, Mem. Sloan Kettering Cancer Ctr., Epithelial mesenchymal transition of epithelial cells induced by TGF-β signaling in lymphedema
- Eleni Tiniakou, Johns Hopkins Univ., Discovery of antigen specific CD4+ T cells in anti-3-hydroxy-3-methylglutaryl coenzyme A reductase (HMGCR) immune mediated necrotizing myopathy (IMNM)
Friday, May 6, 2022 2:00 PM – 4:00 PM Oregon Ballroom 203
Tumor Immunotherapy (TI1)
Chairs
- Eduardo Davila, Univ. of Colorado
- Beth Tamburini, Univ. of Colorado Anschutz Med. Campus
Speakers
- Subir Biswas, Moffitt Cancer Ctr. and Res. Inst., CAR T cells targeting Olfactory Receptor OR2H1 are an effective immunotherapeutic option in human epithelial tumors
- Jiemiao Hu, MD Anderson Cancer Ctr., Cell membrane-anchored and tumor-targeted IL-12 (attIL12)-T cell therapy for eliminating large and heterogeneous solid tumors
- Colin J. Thalhofer, AgonOx Inc., Enriching for tumor-reactive CD8 TIL (AGX148) leads to effective tumor clearance in a patient-derived xenograph model
- Joey C. Magno, Univ. of Colorado Anschutz Med. Campus, A novel linked TCR:MyD88 receptor improves anti-tumor responses while maintaining antigen specificity
- Thomas Duhen, Earle A. Chiles Res. Inst., PD-1 and ICOS co-expression identifies tumor-reactive CD4 Th cells in human solid tumors
- Kathryn M. Laporte, Univ. of Miami, Targeting the high-affinity IL-2R with high-dose mIL-2/CD25 induces effective antitumor responses
- Silvia Guglietta, Med. Univ. of South Carolina, Complement downregulation promotes an inflammatory signature that renders colorectal cancer susceptible to immunotherapy
- Paramita Chakraborty, Med. Univ. of South Carolina, Targeting autophagy with carbon-monoxide reprograms anti-tumor t cells with robust immunometabolic phenotype
Friday, May 6, 2022 2:00 PM – 4:00 PM Oregon Ballroom 201
Vaccines and Immunobiologics against Viruses
Chair
- Fikadu G. Tafesse, Oregon Hlth. and Sci. Univ.
Speakers
- Angela Desmond, Children's Hosp. of Philadelphia, Preventing neonatal herpes: Protection after maternal mRNA-lipid nanoparticle vaccination equals or exceeds that from prior maternal genital infection in murine models
- Ninaad Lasrado, Univ. of Nebraska-Lincoln, A live-attenuated mutant CVB3 vaccine virus protects against multiple coxsackievirus B infections
- Laura Stephens, Univ. of Iowa, Robust efficacy and long-lasting humoral immunity induced by a respiratory syncytial virus prefusion F-based nanoparticle vaccine in genetically diverse animal models
- Yinyan Xu, Univ. of North Carolina at Chapel Hill, Conserved-region MVA vaccines can shift HIV T cell immunodominance in PWH on ART—the M&M Study
- Celeste Huaman, Uniformed Services Univ., Control of established, CNS-resident lyssavirus infection by an adaptive immune response stimulated by single-dose monoclonal antibody therapy
- Husam Taher, Oregon Hlth. and Sci. Univ., T cell programming by the cytomegalovirus MHC class I homologue UL18
- Ramireddy Bommireddy, Emory Univ. Sch. of Med., Influenza virus-like particle-based hybrid vaccine containing RBD induces immunity against influenza and SARS-CoV-2 viruses
- Marta C. Cruz Cisneros, Univ. of North Carolina at Chapel Hill, Genetic analysis of differential responses to adjuvanted influenza vaccination
