Block Symps

Chairs

• Randy S. Longman, Weill Cornell Med.
• Laurence M. Morel, Univ. of Florida Col. of Med.

Speakers

• Rinkesh Kumar Gupta, La Jolla Inst. for Immunology, Therapeutic targeting of tumor necrosis factor like weak inducer of apoptosis (TWEAK) in psoriasis
• Yogesh Scindia, Univ. of Florida, Renal tubular cell ferroptosis: a new player in pathogenesis of lupus nephritis
• Ahmed Samir Elshikha, Univ. of Florida, The gut microbiota transfers the therapeutic effect of inhibiting glucose metabolism in lupus-prone mice
• Svetlana Ferreira Lima, Weill Cornell Med., Defining the role for the gut microbiome in the clinical efficacy of sulfasalazine therapy for IBD associated spondyloarthritis
• Longhuan Ma, Univ. of Florida, A combination of genetic factors and dietary tryptophan shapes gut microbial dysbiosis in a lupus-prone mouse model
• Laura Santambrogio, Weill Cornell Med., Characterization of a novel anti-inflammatory biogenic amine
• Hu Zeng, Mayo Clin. Rochester, The immune dysregulations in inflammatory arthritis immune related adverse events
• Justin Choe, Mayo Clin. Grad. Sch. of BioMed. Sci., ST8Sia6 expression in beta cells mitigates onset of autoimmune diabetes in the murine NOD model

Chairs

• JoAnne L. Flynn, Univ. of Pittsburgh Sch. of Med.
• David A. Rosen, Washington Univ. Sch. of Med.

Speakers

• Yanli Li, Univ. of North Carolina at Chapel Hill, Identification of CPAF as the immunoprevalent antigen of Chlamydia trachomatis
• Jaikin Harrell, Tulane Univ. Sch. of Med., The use of outer membrane vesicles as novel, mucosal adjuvants against intracellular bactiera
• Matthew Bell, Drexel Univ. Col. of Med., The novel adjuvant, ADA-1, restores age-associated defects in the adaptive immune response to Clostridioides difficile infection and vaccination in an aging mouse model
• Valery Cristina Román-Cruz, Univ. of Montana, Adjuvanted multivalent vaccine targeting clinically relevant Pf bacteriophage creates cross-reactive antibodies
• Paeton L. Wantuch, Washington Univ. Sch. of Med., Differential Immune Response to Klebsiella pneumoniae O-antigen subtypes O2v1 and O2v2
• Andrew W. Simonson, Univ. of Pittsburgh Sch. of Med., The role of lymphocyte subsets in preventing tuberculosis following intravenous vaccination with BCG
• Eva Morgun, Feinberg Sch. of Med., Northwestern Univ., Mycolic acid nanoparticle vaccination leads to antigen persistence and unique differentiation of mycobacterial lipid antigen-specific T cells
• Caroline J. Duncombe, Univ. of Washington, Differential sex-specific immune responses following Prime-and-Trap vaccination alters protection against malaria in mice

Chairs

• Melanie R. Rutkowski, Univ. of Virginia
• Irving Allen, Col. of Vet. Med.. Virginia Tech

Speakers

• Kaiting Yang, Univ. of Chicago, Suppression of local IFN-I by commensal microbiota-derived butyrate impairs antitumor effects of ionizing radiation
• Qingsheng Li, Univ. of Louisville, Dietary low-fiber promotes resistance to immune checkpoint inhibitor immunotherapy in the LSL-Kras^G12D Lung Cancer Model
• Romina E. Araya, NCI, NIH, Neutrophil dynamics in the tumor microenvironment determines therapy efficacy and is regulated by microbiota
• Liangliang Wang, Univ. of Chicago, Lactobacillus rhamnosus GG re-shapes gut microbiota and triggers STING-type I IFN-dependent antitumor immunity
• Mitchell Thomas McGinty, Univ. of Virginia, Absence of Toll-like receptor 5 confers survival in mice bearing ovarian tumors treated with anti-PD-L1
• Qingsheng Li, Univ. of Louisville, Resistance to Anti-PD-1 Therapy is mediated via the Microbiota-Th17-Prostoglandin E2 Axis in the LSLKras^G12D Lung Cancer Model
• Khiem C. Lam, NCI, NIH, Tumor-intrinsic factors dictate beneficial effect of microbiota-based therapies

Chairs

• Paul Thomas, St. Jude Children’s Res. Hosp.
• Shitao Li, Tulane Univ. Sch. of Med.

Speakers

• Yakun Wu, Tulane Univ. Sch. of Med., Nuclear soluble cGAS senses DNA virus infection
• Murugesan Rajaram, Ohio State Univ., Influenza A virus modulates ACE2 expression and SARS-CoV-2 infectivity in human cardiomyocytes
• Jenny Resiliac, Research Institute at Nationwide Children’s Hospital, Lipopolysaccharide pre-treatment prevents viral induced death by priming macrophages for a robust anti-viral immune response
• Yi Yao, Henry Ford Hlth. Sys., Circulating monocytes co-expressing surface ACE2 and TMPRSS2 upon TLR4/7/8 activation are susceptible to SARS-CoV-2 infection
• Jennifer R. Connors, Drexel Univ. Col. of Med., The impact of lipid nanoparticles (LNP) on anti-viral pathways and immune function in aged individuals
• Marissa Lindman, Rutgers Univ., Astrocytic RIPK3 confers protection against deleterious neuroinflammation during Zika virus infection
• Anshu Agrawal, Univ. of California Irvine, Innate immune mechanisms underlying sex differences in COVID-19

Chair

• Aaron Johnson, Mayo Clin. Rochester

Speakers

• Arya Biragyn, NIA, NIH, A surprising pathogenic role of B cells in mice with Alzheimer’s disease
• Pooja Jain, Drexel Univ. Col. of Med., Nutraceutical Apigenin regulates DC function in a RelB-dependent manner during neuroinflammation
• Zhangying Chen, Feinberg Sch. of Med., Northwestern Univ., T-cell infiltrates and microglia adopt long-term gene signature changes leading to age-specific responses to traumatic brain injury in mice
• Ling Cao, Univ. of New England, Responses of injured nerve in CD137L knockout mice following sciatic nerve crush-induced neuropathic pain
• Murugaiyan Gopal, Brigham and Women’s Hosp. and Harvard Med. Sch., MicroRNA control of inflammatory and regulatory T cells in CNS autoimmunity
• Ling Cao, Univ. of New England, Electromyographic characterization and bioinformatic pathway analysis of spinal cord inflammation in a Tat induced HIV-associated sensory neuropathy model
• Yan Wang, Thomas Jefferson Univ., Single-cell RNA sequence (scRNAseq) analysis of T regulatory cells in relapsing remitting multiple sclerosis (RRMS)

Chairs

• Leah Kottyan, Cincinnati Children’s Med. Ctr.
• Betsy Barnes, The Feinstein Inst. for Med. Res., Northwell Hlth.

Speakers

• Bharati Matta, Feinstein Inst. for Med. Res., IRF5 risk variants contribute to pre-symptomatic SLE by enhancing the levels of circulating NET antigens
• Morgan Lee Terrell, Univ. of Florida, Treatment with TLR7/8 agonist compromises intestinal epithelium integrity in a lupus prone mouse model
• Kevin MingJie Gao, Univ. of Massachusetts Med. Sch., Radioresistant cells in STING gain-of-function mice initiate lymphocyte dependent lung inflammation and IFNγ dependent mortality
• David Nemazee, Scripps Res. Inst., Cleavage of DNA and RNA by PLD3 and PLD4 limits autoinflammatory triggering by multiple sensors, including endolysosomal TLRs and a STING dependent sensing pathway
• Mitra Padideh Maz, Univ. of Michigan, Understanding innate immune cell-mediated inflammation in UV-induced skin injury in lupus-prone mice
• William J. Turbitt, Univ. of Alabama at Birmingham, Neutrophil-specific Socs3 deficiency induces brain-targeted experimental autoimmune encephalomyelitis with enhanced cerebellar neutrophil activation
• Shailesh K. Shahi, Univ. of Iowa, HLA Class II polymorphisms influence gut microbiota composition and modulate disease in transgenic mice model of multiple sclerosis
• Mary A. Markiewicz, Univ. of Kansas Med. Ctr., The role of NKG2D signaling in NOD diabetes is affected by the microbiota

Chairs

• Amanda M. Burkhardt, Univ. of Southern California
• Yuri Sykulev, Thomas Jefferson Univ.

Speakers

• Joseph Cornelius Lownik, Cedars Sinai Med. Ctr., Expanding the use of clustering and dimensionality reduction in high parameter flow cytometry data through machine learning for novel samples
• Vaishnavi Kaipilyawar, Rutgers New Jersey Med. Sch., Derivation of a parsimonious Tuberculosis gene signature using the digital NanoString nCounter platform
• Lanaiah M. Ieremia, Texas Tech Univ. Hlth. Sci. Ctr. El Paso, Host-targeted self-attenuated influenza virus as a potential therapeutic influenza vaccine
• Shijie Cao, Univ. of Chicago, Lymph node-targeted long-acting butyrate micelles induce regulatory immune modulation
• Sophia Liu, MIT, Spatially mapping T cell receptors and transcriptomes
• Irene E. Whitney, Honeycomb Biotechnologies, HIVE Single-cell TCR sequencing: assay principle and applications
• Sheila Burns, Applied Cells, Inc., A multi-physics approach for high recovery and purity isolation of plasma cells in whole blood

Chairs

• Emily M. Mace, Columbia Univ.
• Elissa Deenick, Garvan Inst. of Med. Res.

Speakers

• Ruth J. Napier, Oregon Hlth. and Sci. Univ., T cell intrinsic role for NOD2 in Blau Syndrome
• Marita Bosticardo, NIAID, NIH, Characterization of thymic epithelial cell and thymocyte function and development in patients with thymic defects using scRNAseq profiling
• Zinan Zhang, Harvard Med. Sch., Bi-allelic TTC21A mutations in common variable immunodeficiency patients
• Sukalp Muzumdar, Cold Spring Harbor Lab., A granular view of X-linked chronic granulomatous disease exploiting single-cell transcriptomics
• Julia Bier, Garvan Inst. of Med. Res., Australia, T cell extrinsic mechanics explaining the T cell hyperactivation seen in Activated PI3K δ Syndrome
• Nicolai S. van Oers, Univ. of Texas Southwestern Med. Ctr., 22q11.2 deletion syndrome causes a thymus hypoplasia corrected by mesenchymal cell replacement
• Olivia Bailey, Univ. of Colorado Anschutz Med. Campus, Dissecting the effect of a novel hypomorphic IL2RB mutation on immune dysregulation
• Jose S. Campos Duran, Perelman Sch. of Med., Univ. of Pennsylvania, Dysregulation of CD8⁺ T cell function in the setting of altered cytokine signaling due to inborn errors of immunity

Chairs

• Jose R. Conejo-Garcia, H. Lee Moffitt Cancer Ctr. and Res. Inst.
• Fathia Mami-Chouaib, INSERM U1186, France

Speakers

• Hui Zhang, Washington State Univ., Tissue-resident memory CD4+ T cells play a dominant role in the initiation of antitumor immunity
• Michael J. Gough, Providence Portland Med. Ctr., Tumor resident memory CD8 T cell formation and concomitant tumor immunity is CD40L dependent and CD4 independent
• Nu Zhang, Univ. of Texas Hlth. Sci. Ctr. at San Antonio, TGF-β-dependent Lymphoid Tissue Residency of Stem-like T cells Limits the Response to Tumor Vaccine
• Carmen Mariam Anadon Galindo, H. Lee Moffitt Cancer Ctr. and Res. Inst., Ovarian cancer immunogenicity is governed by a narrow subset of progenitor tissue-resident memory T-cells
• Noah Veis Gavil, Univ. of Minnesota, Chronic antigen in solid tumors drives a distinct program of T cell residence
• Fathia Mami-Chouaib, INSERM U1186, France, Resident memory T cells in antitumor immunity and cancer immunotherapy

Chairs

• Akiko Iwasaki, Yale Sch. of Med.
• Henrique Borges da Silva, Mayo Clin.

Speakers

• Henrique Borges da Silva, Mayo Clin., Establishment of influenza-specific lung tissue-resident helper memory CD4⁺ T cells relies on expression the eATP sensor P2RX7
• E. Taylor Stone, St. Louis Univ, Sch. of Med., Requirement for robust T and B cell responses for immune protection against Powassan virus (POWV) in virus-like particle (VLP) vaccination
• Christopher Ned Jondle, Med. Col. of Wisconsin, T cell-intrinsic IL-17RA signaling in the spleen supports the establishment of chronic gammaherpesvirus infection
• Yexin Yang, Yale Sch. of Med., Glycan-specific B-1 cells mediate blockade of endogenous retroviruses emergence through recognition of conserved glycan epitopes
• Antonio Cembellin Prieto, Univ. of California, Davis, B cell-derived acetylcholine controls local inflammation and replication of influenza virus during respiratory tract infections
• Jalene V. Velazquez, Washington State Univ., Distinct antibody profiles against Ebola virus track with the development of Post-Ebola Syndrome.
• Ariana Denise Campbell, Johns Hopkins Bloomberg Sch. of Public Hlth., Influenza A virus-specific maternal antibodies impair vaccine-induced antibody responses and protection in male to a greater extent than female offspring
• Jenna Guthmiller, Univ. of Chicago, B cell convergence to distinct broadly reactive epitopes revealed by chimeric hemagglutinin vaccination