IMMUNOLOGY2022™

May 6–10, 2022 | Portland, Oregon

Block Symps

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Big Data: The Key to Unlocking Immune Mediated Mechanisms of Tumor Progression and Therapy Response

Chairs

  • Mary Philip, Vanderbilt Univ. Med. Ctr.
  • Sepideh Dolatshahi, Univ. of Virginia

Speakers

  • Joshua Brand, Univ. of Wisconsin-Madison, Single-cell myeloid diversity in human fallopian tube and its implications for early high grade serous ovarian cancer
  • Nicola S. Meagher, Univ. of New South Wales, Multi-modal immune profiling of mucinous ovarian carcinoma: analysis from the Ovarian Tumor Tissue Analysis/Multidisciplinary Ovarian Cancer Outcomes Group consortia
  • Mieszko Lachota, Med. Univ. of Warsaw, Analysis of chemokine network in primary human glioblastoma
  • Cristina F. Contreras, NCI, NIH, Transcriptomic and epigenetic profiling of tumor-associated monocyte function
  • Huy Dinh, Univ. of Wisconsin-Madison, Defining myeloid plasticity and heterogeneity in immunotherapy response
  • Vivien Ileana Maltez, NIAID, NIH, Multiplex microscopy reveals unique spatiotemporal effects of cancer immunotherapies
  • William L. Redmond, Earle A. Chiles Res. Inst., Multimodal single-cell analysis of human TILs across multiple tumor types reveals heterogeneity and potential opportunities for personalized immunotherapy
  • Abigail L. Sedlacek, Univ. of Pittsburgh, Identification of immunogenic peptide neoantigens expressed in sarcomas and their therapeutic potential

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Mucosal Innate Immune Cells

Chairs

  • Andea Reboldi, Univ. of Massachusetts Med. Sch.
  • Paige Porrett, Univ. of Alabama at Birmingham Sch. of Med.

Speakers

  • Wan-Jung Wu, Mem. Sloan Kettering Cancer Ctr., Select mucosa-associated intestinal commensal bacteria promote gut barrier repair by inducing IL-1b production
  • Michela Frascoli, Univ. of Massachusetts Med. Sch., Crosstalk between skin homing innate T cells and epithelial cells via cholesterol byproduct messengers is required for tissue immunity
  • Jia Nie, NCI, NIH, The transcription factor LRF promotes Integrin β7 expression by and gut homing of CD8αα intraepithelial lymphocyte precursors
  • Xuqiu Lei, Univ. of Massachusetts Chan Med. Sch., Epithelial HNF4A shapes the intraepithelial lymphocyte compartment via direct regulation of immune signaling molecules
  • Angeline Chen, La Jolla Inst. for Immunology, Small intestine epithelial CD4 cytotoxic T lymphocytes provide innate-like protection against enteric pathogens without risk of immunopathology
  • Paige Porrett, Univ. of Alabama at Birmingham Sch. of Med., Aberrant survival of uterine natural killer subsets in uterus transplant recipients
  • Thanh Thanh Trinh Dinh, The Ohio State Univ. Col. of Med., ILC3 expansion in acute myeloid leukemia

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T Cell Effector Generation and Function

Chairs

  • Takeshi Egawa, Washington Univ. Sch. of Med.
  • Sarah Hamilton, Univ. of Minnesota

Speakers

  • Anna Halling Folkmar Andersen, Aarhus Univ., Single-cell TCR and mRNA sequencing of antigen-specific T cells reveal spatial trajectories from single time points with HLA and VDJ bias
  • Ao Guo, St. Jude Children’s Res. Hosp., The SWI/SNF canonical BAF complex and c-Myc cooperate to promote early fate decisions in CD8+ T cells
  • Jessica A. Gaevert, St. Jude Children’s Res. Hosp., Characterization of the cross-reactive T cell repertoire in the context of heterosubtypic influenza A virus infection
  • Erin D. Lucas, Univ. of Minnesota, Expansion and maintenance of long lived effector CD8 T cells is modulated by inflammation
  • Yu Xia, Washington Univ. in St Louis Sch. of Med., BCL6-dependent TCF-1+ progenitor cells maintain effector and helper CD4 T cell responses to persistent antigen
  • Mirela Kuka, Università Vita Salute San Raffaele, A fluorescent reporter model to study the role of TDC during infection and cancer

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Molecular Mechanisms of Inflammation

Chairs

  • Kristin Patrick, Texas A&M Univ., Col. of Med.
  • Brooke Napier, Portland State Univ.

Speakers

  • Haley M. Scott, Texas A&M Hlth. Sci. Ctr., Serine Arginine Splicing Factor 7 (SRSF7) is a critical regulator of innate immune activation in macrophages
  • Stephanie R. Shames, Kansas State Univ., Effector-mediated subversion of proteasome activator (PA)28αβ enhances lysosomal pathogen targeting within cytokine-activated macrophages
  • James Robert Fisher, Univ. of Texas Med. Br. at Galveston, Mincle and TNF signaling crosstalk enhances type 1 and innate immune responses to Orientia tsutsugamushi
  • Antonio J. Pagán, Univ. of Cambridge, mTOR-associated mitochondrial energy metabolism limits mycobacterium ESX-1-induced cytotoxicity
  • Amy Lorraine Seufert, Portland State Univ., Palmitic acid reprograms inflammatory responses to microbial ligands in macrophages, and mediates innate immune memory in vivo
  • Haleigh Gilliland, Michigan State Univ., Defining complex mechanistic interactions and responses by macrophages during Mycobacterium abscessus infection
  • Cheyenne Palm, Towson Univ., NADase activity found in bacterial TIR proteins may aid in innate immune evasion
  • Michal Caspi Tal, Stanford Univ. Sch. of Med., P66 is a bacterial “don’t eat me signal” that mimics mammalian CD47 and facilitates immune evasion by Borrelia burgdorferi

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Infection and Disease

Chairs

  • Marta Catalfamo, Georgetown Univ. Sch. of Med.
  • Bethany Mundy-Bosse, The Ohio State Univ. Col. of Med.

Speakers

  • Tanya Novak, Boston Children’s Hosp. and Harvard Med. Sch., Genes associated with multiple organ dysfunction syndrome during severe pediatric influenza
  • Julie G. Burel, La Jolla Inst. for Immunology, Profiling the myeloid compartment of PBMC in active tuberculosis reveals substantial changes in CD14+ cells and upregulation of CD16 in pro-inflammatory dendritic cells
  • Jeffrey Alan Tomalka, Emory Univ. Sch. of Med., Inflammasomes and IL-1β: an innate immune axis in CD4+ T cells driving HIV infection and disease progression
  • Hadas Tamar Pahima, Hebrew Univ. of Jerusalem, COVID-19 patients are characterized by increased levels of immune cell membrane-bound and soluble CD48
  • Sarah C. Glover, Univ. of Mississippi Med. Ctr., Circulating extracellular vesicles from patients with severe COVID-19 upregulate Cathepsin B and activate STAT3 in normal human mesangial cells
  • Josh S. Mytych, Oklahoma Med. Res. Fndn., Bacillus anthracis peptidoglycan alters human M2-like macrophage phenotype and efferocytic function in the presence of human serum
  • Ismaila L. Manneh, London Sch. of Hygiene and Tropical Med., Targeted transcriptomic signature for monitoring anti-tuberculosis treatment response
  • Yashoda Madaiah Hosakote, Univ. of Texas Med. Br. at Galveston, SARS-CoV-2 induced oxidative stress promotes HMGB1 secretion to induce inflammation

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Overcoming Current Roadblocks in CAR T Cell Therapy

Chair

  • Anna Halling Folkmar Andersen, New York Univ. Langone Med. Center

Speakers

  • Monika Kizerwetter, Johns Hopkins Univ., Anti-CD123 chimeric antigen receptor natural killer cell therapy to treat acute myeloid leukemia
  • Nicholas R. J. Gascoigne, Natl. Univ. of Singapore, Utilizing distinct CAR and TCR signaling to generate enhanced cellular immunotherapy
  • Daniel S. Wilkinson, Duke Univ. Med. Ctr., D2C7 CAR: A novel CAR T cell that simultaneously targets wildtype EGFR and its mutant isoform EGFRvIII for treatment of glioma
  • Jillian Baker, Univ. of Maryland Sch. of Med., Engineering anti-CD229 CAR T cell selectivity for multiple myeloma
  • Xander Gordon Ray Bradeen, Univ. of Colorado Anschutz Med. Campus, Identifying novel epigenetic modifiers that sensitize T cell malignancies to CD8+ T cell mediated cytotoxicity by high throughput drug screen
  • Royce Ma, Baylor Col. of Med., T cells resist CD5 CAR mediated fratricide by continuously degrading CD5 protein
  • Caitlin C. Zebley, St. Jude Children’s Res. Hosp., CD19-CAR T cells develop exhaustion epigenetic programs during a clinical response
  • Nayan Jain, Mem. Sloan Kettering Cancer Ctr., SUV39H1 disruption imparts functional persistence to CD28-costimulated human CAR T cells

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Molecular, Metabolic, and Epigenetic Regulation of Innate Immunity and Inflammation

Chairs

  • Connie Krawczyk, Van Andel Inst.
  • Sarah Ewald, Univ. of Virginia

Speakers

  • Chao Yang, Hosp. for Special Surgery, Costimulation of TLR8 responses by CXCL4 in human monocytes mediated by TBK1-IRF5 signaling and epigenomic remodeling
  • Matthew D. Woolard, Louisiana State Univ. Hlth. Sciences Ctr. at Shreveport, Lipin-1 integrates lipid metabolism with macrophage function to promote inflammation resolution
  • David Orlando Diaz-Jimenez, NIEHS, NIH, Glucocorticoids suppress NLRP3 Inflammasome activation through transcriptional metabolic reprogramming of IRG-1/ACOD1 in macrophages
  • Raza Ali Naqvi, Univ. of Illinois at Chicago, Modulation of myeloid cell functions by long noncoding RNAs RN7SK and HCG11
  • Alicer Keendalyn Andrew, Univ. of Georgia, Relationships between inflammation, coagulation, and oxidative stress in malaria-induced pregnancy compromise
  • Abhimanyu Abhimanyu, Baylor Col. of Med., Targeting TCA cycle metabolites by small molecule inhibitors ameliorate LPS induced immune tolerance in Macrophages through epigenetic mechanisms
  • Katherine E. Lothstein, Rutgers Univ. New Jersey Med. Sch., Helminth TGF-β mimic, TGM, increases leukocyte migration and activation while also enhancing cutaneous wound healing and tissue regeneration

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B and T Cell Development

Chairs

  • Ann Griffith, Univ. of Texas Hlth. Sci. Ctr. San Antonio
  • Neetu Gupta, Cleveland Clin.

Speakers

  • Sarah A. Wedemeyer, Univ. of Texas Hlth. Sci. Ctr. at San Antonio, Role of paracrine mTOR signaling in regulating thymus size and function
  • Katherine Maude Ashby, Univ. of Minnesota, Thymic interferon impacts T cell selection
  • Tom N. Taghon, Ghent Univ., Belgium, An unexpected role for IRF8 during human T cell development
  • Breanna P. Caruso, Oregon Hlth. & Sci. Univ., A lineage specific role for PD-1 in agonist selection in the thymus
  • Jonathan E. Boyson, Univ. of Vermont, Single-cell proteogenomics reveals that SLAM/SAP signaling regulates the development of innate-like γδ T cell subsets with distinct TCR repertoires
  • Varun Aysola, Cleveland Clin., Ezrin promotes antigen receptor diversity during B cell development by supporting immunoglobulin heavy chain variable gene recombination
  • Michael Jonathan Lehrke, Mayo Clin., ABCB7 is required for B cell development, proliferation, and class switch recombination

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Autoantigen Identification, Autoantigen Specificity, and Central Tolerance

Chairs

  • Maria Bettini, Univ. of Utah Sch. of Med.
  • Kristin Hogquist, Univ. of Minnesota

Speakers

  • Mekha A. Thomas, Johns Hopkins Univ. Sch. of Med., The monocyte cell surface as a novel site of autoantigen generation in Rheumatoid Arthritis
  • Mianmian Yin, Univ. of California, San Francisco, Autoantigen specific T-cell receptor induces organ-specific autoimmunity by escaping T cell negative selection
  • Alexander J. Dwyer, Univ. of Minnesota, CD4+ T cells targeting a hybrid insulin: chromogranin A self-antigen are necessary and sufficient for autoimmune diabetes initiation
  • Yi Jing, Baylor Col. of Med., Insulin specific TCR repertoire analysis reveals functional diversity of Treg TCRs
  • Paul Zdinak, Univ. of Pittsburgh Sch. of Med., Profiling transcriptomes, TCR repertoires, and antigenic specificities of islet-infiltrating T cells in non-obese diabetic mice
  • Jun Hyung Sin, Univ. of California, San Francisco, Control of medullary thymic epithelial cell development and central tolerance by a zinc finger transcription factor
  • Ryan J. Martinez, Univ. of Minnesota, Type III interferon enhances thymic B cell licensing
  • Gregory J. Tsay, China Med. Univ., A specific 25-mer peptide from the cysteine protease of P. gingivalis is the epitope of humoral immune response in rheumatoid arthritis

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Immunity to SARS-CoV-2

Chairs

  • Emily Hemann, The Ohio State Univ., Col. of Med.
  • Paul Thomas, Saint Jude Children’s Res. Hosp.

Speakers

  • Abigail Solstad, Ohio State Univ., Endogenous interferon-lambda signaling restricts virus replication and disease severity in a murine model of SARS-CoV-2 infection
  • Jodi F. Hedges, Montana State Univ., ADAM-17 protease promotes inflammation and mortality while decreasing viral burden in a COVID-19 mouse model
  • Xiao He, Univ. of Utah, A longitudinal study of humoral immune responses to SARS-CoV-2 spike proteins in gamma-interferon-inducible lysosomal thiol reductase deficient mice
  • Hejun Liu, Scripps Res. Inst., The human IGHD3-22 encoded motif contributes to broad reactivity of anti-SARS-CoV-2 antibodies
  • Jennifer R. Habel, Univ. of Melbourne, at Peter Doherty Inst. for Infection and Immunity, Integrated immune networks in SARS-CoV-2 infected pregnant women reveal differential NK cell and unconventional T cell activation
  • Krista L. Newell, SUNY Upstate Med. Univ., Spike BATTLE: Simultaneous evaluation of antigen-specific B and T lymphocytes following natural SARS-CoV-2 infection and subsequent mRNA vaccination
  • Alba Grifoni, La Jolla Inst. for Immunology, SARS-CoV-2 vaccination induces T cell memory responses able to cross-recognize ongoing SARS-CoV-2 variants including omicron
  • Anastasia Minervina, St. Jude Children’s Res. Hosp., Epitope-specific T cell response to SARS-CoV-2 infection and vaccination