Block Symps

Chairs

• De’Broski Herbert, Univ. of Pennsylvania Sch. of Vet. Med.
• Tracey Lamb, Univ. of Utah

Speakers

• Jenna Reed, Univ. of Utah Sch. of Med., Plasmodium infection elevates risk of severe secondary bacterial disease by altering the immunological landscape of the lung
• Oscar Rosas Mejia, Ohio State Univ. Col. of Med., Mice infected with Mycobacterium tuberculosis are resistant to secondary infection with SARS-CoV-2
• Nicolas Olive Jean Millet, Harbor-Univ. of California, Los Angeles Med. Cntr., IL-23 signaling limits ferroptosis-driven immunopathology during systemic fungal infection
• Trung Hoang Minh Pham, Stanford Univ. Sch. of Med., Single-cell profiling identifies ACE⁺ granuloma macrophages as a non-permissive niche for intracellular bacteria during persistent Salmonella infection
• Yazmin Berenice Martinez-Martinez, Univ. of Texas Med. Br. at Galveston, HIV compromises Th17 and Th22 immunity in a humanized mouse model of Tuberculosis and HIV co-infection
• E. Evonne Jean, Univ. of Pennsylvania Sch. of Vet. Med., Exploring cutaneous neuro-immune networks during helminth infection
• Nana K. Minkah, Seattle Childrens Res. Inst., Type I Interferon remodels intrahepatocytic signaling to promote T cell dysfunction during liver stage Plasmodium infection
• Romaniya Zayats, Univ. of Manitoba, Cellular dynamics of immune evasion during Leishmania major infection

Chairs

• Benjamin Hurrell, Univ. of Southern California
• Omid Akbari, Keck Sch. of Med., Univ. of Southern California

Speakers

• Karine Bouchard, Quebec Heart and Lung Inst., Université Laval, Macrophage inflammatory response increases in adult female exposed to neonate stress
• Hector M. Nieves-Rosado, Univ. of Pittsburgh Sch. of Med., Tim-3 deletion on Treg increases virus-specific T cell response and reduces viral burden in chronic LCMV infection
• Kunal Dhume, Univ. of Central Florida, Robust homotypic and heterosubytpic immunity against Influenza A Virus in mice lacking Th1/Tc1 transcriptional machinery
• Manuja Gayashan Bandara Gunasena, Ohio State Univ., Immune determinants of cardiometabolic risk in pre-existing type-2 diabetes (T2D) severe COVID-19 patients
• Monique M. Waldman, Univ. of Colorado Anschutz Med. Campus, Ena/VASP protein-mediated actin polymerization contributes to naive CD8⁺ T cell activation and expansion by promoting T cell-APC interactions in vivo
• Mahmoud Abdelbary, Oregon Hlth. and Sci. Univ., Core fucosylation of N-linked glycans: a novel player in memory CD8⁺ T cell differentiation following acute viral infection
• Thu A. Doan, Univ. of Colorado Anschutz Med. Campus, Archived antigen boosts CD8 T cell memory responses during an unrelated infection

Chairs

• Rebecca Martin, Virginia Commonwealth Univ.
• De’Broski Herbert, Univ. of Pennsylvania Sch. of Vet. Med.

Speakers

• Jorge F. Ortiz-Carpena, Perelman Sch. of Med., Univ. of Pennsylvania, Sensory neurons shape allergic Type 2 inflammation in the sinonasal tract
• Anukul T. Shenoy, Boston Univ., Mouse model of late-onset neutrophilic asthma reveals an epithelium-lymphocyte-neutrophil communication circuit underlying destructive airway neutrophilia
• Jihyun Yu, Korea Advanced Inst. of Sci. and Technol., GPR43 signaling in lung eosinophils suppresses neutrophilic airway inflammation in asthma
• Rama Krishna Gurram, NHLBI, NIH, TSLP and IL-33 distinctively modulate the allergic response by differentially modulating Th2 cells and ILC2sM
• Anuj Tharakan, Virginia Commonwealth Univ. Sch. of Med., Blockade of dendritic cell glutaminolysis induces allergic asthma desensitization via suppression of Tfh13 polarization
• Abigail Pajulas, Indiana Univ. Sch. of Med., T_H9-derived IL-9 promotes CCR2-dependent mast cell accumulation in the allergic lung
• Ceire Hay, Perelman Sch. of Med., Univ. of Pennsylvania, Interrogating mechanisms of CD8 T cell dysfunction in obese asthma
• Lars P. Lunding, Res. Ctr. Borstel, The NLRP3 Inflammasome Inhibitor OLT1177® Ameliorates Experimental Allergic Asthma in Mice

Chairs

• Amelia Pinto, Saint Louis Univ. Sch. of Med.
• Majid Kazemian, Purdue Univ.

Speakers

• Elizabeth Geerling, St. Louis Univ., Sch. of Med., Metabolic syndrome enhances viral disease severity and reduces vaccine efficacy in mice
• Jian Zheng, Univ. of Iowa, Eicosanoid signaling as a therapeutic target in middle-aged mice with severe COVID-19
• Stephen T. Yeung, Weill Cornell Grad. Sch. of Med. Sci., Galectin-9 protects humanized-ACE2 immunocompetent mice from SARS-CoV-2 Infection
• Bingyu Yan, Purdue Univ., SARS-CoV-2 drives JAK1/2-dependent local complement hyperactivation
• Ksenia Rybkina, Columbia Univ. Med. Ctr., Children with Multi-System Inflammatory Syndrome (MIS-C) develop functionally competent T cell memory against SARS-CoV-2 following recovery
• Zehra Rahman, Univ. at Buffalo Sch. of Med. and BioMed. Sci., Exploration of shared antibody motifs in Kawasaki Disease (KD) and COVID-19 related Multisystem Inflammatory Syndrome of Childhood (MIS-C)
• Brandi L. Clark, St. Jude Children’s Res. Hosp., Identifying distinct T cell subsets in the context of pediatric ARDS
• Yu Gao, Karolinska Inst., SARS-CoV-2 mRNA vaccination induces polyfunctional T cell responses in healthy and immunocompromised individuals

Chairs

• Katelyn T. Byrne, Oregon Hlth. and Sci. Univ.
• Ichiko Kinjyo, Univ. of New Mexico

Speakers

• Jihae Ahn, Feinberg Sch. of Med., Northwestern Univ., Enhancing the antitumor response of CD8⁺ T cells by 4-1BB (CD137) co-stimulation with distinct inactivation of the type 2 adenosine receptors
• Mark E. Issa, Univ. of Montreal, Glycogen synthase kinase (GSK-3) synergizes with PD-1/PDL1 blockade to generate super-armed CD8 killers against tumors
• Sora Suzuki, Roswell Park Comprehensive Cancer Ctr., Complement C3 deficiency enhances anti-CD47 efficacy in murine ovarian cancer model
• Jasmine E. Trigg, Sartorius, Evaluation of checkpoint inhibitor therapies using a mixed lymphocyte reaction (MLR) assay
• Nikolaos E. Patsoukis, Beth Israel Deaconess Med. Ctr., Harvard Med. School, Treatment with exogenously added catalase promotes differentiation and function of central memory CD8⁺ T cells
• Allison Christians, Univ. of Colorado Anschutz Med. Campus, DNA-PK inhibition plus immune adjuvants promotes CD8 TIL infiltration, neoantigen presentation, and diversifies the tumor-reactive TCRβ repertoire in B16 melanoma
• Ichiko Kinjyo, Univ. of New Mexico, PARP-inhibition with IFNg in the ovarian tumor microenvironment induces immunogenic cancer cell death for sustained anti-tumor immunity

Chairs

• Gianna E. Hammer, Duke Univ.
• Shipra Vaishnava, Brown Univ.

Speakers

• Michael Stolley, Univ. of Minnesota, Leveraging resident memory t cells to fortify oral immunity
• Gabriel Antonio Ascui-Gac, La Jolla Inst. for Immunology, RAMP3 unexplored relevance for innate-T cell immunity
• Colette Matysiak, Harvard Med. Sch., Intranasal, not parenteral, vaccination induces the formation of tissue-resident memory CD8 T cells in nasal mucosa that rapidly clear influenza virus infection
• Tanvi Arkatkar, Univ. of Washington, Bystander CD8 T cell memory responses partially protect mice against lethal vaginal HSV-2 challenge
• Vineet Joag, Univ. of Minnesota, Sensing and alarm function of vaccine-elicited SIV-gag specific CD8 T_RM in the reproductive mucosa of rhesus macaques
• Elaine Kouame, Univ. of Chicago, The miseducation of T cells in autoimmunity
• Ziqi Chen, Harvard Med. Sch., Parenteral vaccination strategies target protective immunity to the small and large intestine mucosa
• Gowri Kalugotla, Washington Univ. in St Louis Sch. of Med., The autophagy gene Epg5 promotes susceptibility to enteric viral infection

Chairs

• Wei Luo, Indiana Univ. Sch. of Med.
• Patricia Gearhart, NIA, NIH

Speakers

• Carlos J. Ticas Rodas, NIA, NIH, Follicular B cells from old mice are hyper-responsive and produce non-specific antibodies
• Christian Cervantes, Univ. of Texas Hlth. Sci. Ctr. San Antonio, PD-L1 plays a B cell-intrinsic role in suppressing the antibody response and anti-tumor immunity
• Wei Luo, Indiana Univ. – Sch. of Med., Blimp1 controls GC B cell expansion and exit through regulating cell cycle progression and key transcription factors BCL6 and IRF4
• Kim Good-Jacobson, Monash Univ., Targeting intrinsic regulators of antibody and B cell memory to control chronic viral infection
• William Voss, Univ. of Texas at Austin, Differential serological immune imprinting following SARS-CoV-2 infection, vaccination, and breakthrough infection
• Brian T. Gaudette, Perelman Sch. of Med., Univ. of Pennsylvania, The plasma cell proteome initiates early in B cell activation in advance of Blimp-1
• J. Scott Hale, Univ. of Utah Sch. of Med., Tet2-mediated programing balances T follicular helper cell and T helper 1 cell differentiation
• Nicole M. Arroyo, Univ. of Alabama at Birmingham, A temporal switch in T follicular helper cells controls the output of the GC response to influenza

Chairs

• Veena Taneja, Mayo Clin.
• Hsin-Jung Wu, The Ohio State Univ. Col. of Med.

Speakers

• Jacob William Shelton Martens, Univ. of Michigan, The role of skin-derived IFN-kappa in the development of systemic autoimmunity
• Jonathan D. Crawford, Johns Hopkins Univ. Sch. of Med., XIST is a source of TLR7 ligands underlying the sex bias in Systemic Lupus Erythematosus
• Nirmal K. Banda, Univ. of Colorado Anschutz Med. Campus, A snap shot of complement gene expression and presence of complement proteins in synovial biopsies from early rheumatoid arthritis patients
• Diego A. Espinoza, Perelman Sch. of Med., Univ. of Pennsylvania, Proteogenomic immune signatures delineate the landscape of pediatric acquired demyelinating syndromes
• Bonnie Blomberg, Univ. of Miami Miller Sch. of Med., Old mice and elderly humans make increased autoimmune antibodies, inflammation and SASP from aged-increased B cells (ABCs in mice and DN in humans) which are hypermetabolic
• Sarah Alice Long, Benaroya Res. Inst., CD8 T cell exhaustion is reduced in subjects with autoimmune-associated DR4 risk alleles
• Adebowale Bamidele, Mayo Clin. Rochester, Metabolic dysfunction governs regulatory t cell inflammatory response during inflammatory bowel disease
• Alice E. Wiedeman, Benaroya Res. Inst., Differential therapeutic modulation of exhaustion among autoreactive and global CD8 T cells in type 1 diabetes (T1D)

Chairs

• Renukaradhya Gourapura, The Ohio State Univ.
• Rob Miller, Univ. of New Mexico

Speakers

• Aryana Razmara, Univ. of California, Davis, Optimization of expansion techniques for adoptive NK cell transfer in dogs with cancer
• Kimberly A. Morrissey, Univ. of New Mexico, The biology of the unconventional γμ T cell in the opossum Mondodelphis domestica
• Renukaradhya J. Gourapura, Ohio State Univ., Plant derived Nano-11 particle adsorbed with stimulator of interferon genes adjuvant and split influenza virus antigens elicits the cross-protective immunity in pigs
• Jordan M. Sampson, Univ. of New Mexico, B cell ontology in a model marsupial
• Ahmed Attaya, Univ. of Massachusetts Lowell, scRNA-Seq profiling of stickleback fish splenocytes: expansion of myeloid and B cells on immunization
• Matthieu Paiola, Univ. of Rochester Med. Ctr., Flt3 and its ligand as an ancient regulators of dendritic cells: evidence in the amphibian Xenopus laevis
• Hanover C. Matz, Univ. of Maryland, Baltimore, B cell selection sites in the nurse shark spleen may represent evolutionary precursors of mammalian germinal centers
• Yvonne Drechsler, Western Univ. of Hlth. Sci., Characterization of cellular subpopulations and their gene expression by single-cell RNA sequencing in canine atopic dermatitis

Chairs

• Ingunn Stromnes, Univ. of Minnesota
• Carl Ware, Sanford Burnham Prebys Med. Discovery Inst.

Speakers

• Nina Beryl Horowitz, Stanford Univ., Overcoming barriers to solid tumor immunotherapy using natural killer cell therapies designed to mimic intraepithelial group 1 innate lymphoid cells
• Meagan R. Rollins, Univ. of Minnesota Med. Sch., Adoptive transfer of Trac-targeted T cell receptor engineered T cells with defective Tgfbr2 signaling promotes pancreatic cancer eradication
• Karen Michelle Christie, Univ. of Delaware, Directing T cell alloreactivity against solid tumors through tumor antigen dependent TCR expression
• Zachariah Peter Tritz, Mayo Clin. Grad. Sch. of BioMed. Sci., Combination of αPD-1 and extended half-life IL-2 is effective against the GL261 glioma and uniquely reverses GBM-associated immunosuppression
• Travis J. Shute, UT Hlth. San Antonio, Glycolipid-loaded nanoparticle immunotherapy cooperates with checkpoint inhibitors to harness iNKT cells for tumor control
• Aliyah Brianne Silver, Johns Hopkins Bloomberg Sch. of Public Hlth., A tumor-targeted cytokine/antibody fusion protein to stimulate anti-cancer immunity
• Kyle Alexander Romine, Oregon Hlth. and Sci. Univ., BET inhibitors synergize with anti-PD1 by rescuing TCF1+ progenitor exhausted T cells in acute myeloid leukemia
• Hien T. Huynh, Univ. of Missouri Columbia, Dissecting molecular mechanisms underlying T cell co-potentiation when targeting the TCR/CD3 complex with anti-CD3 Fab fragments