IMMUNOLOGY2022™

May 6–10, 2022 | Portland, Oregon

Block Symps

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Mechanisms of Resistance to Therapy

Chairs

  • Jim Song, Texas A&M Univ.
  • William Lu, Univ. of Arkansas for Med. Sci.

Speakers

  • Arshmeet K. Chawla, Univ. of Connecticut Hlth. Ctr., β-adrenergic signaling modulates the development and activity of erythroid suppressor cells
  • Jianmei Wu Leavenworth, Univ. of Alabama at Birmingham, Remodeling of the tumor microenvironment via disrupting effector Treg activity augments response to checkpoint blockade
  • Avery Janese Salmon, Univ. of Texas MD Anderson Cancer Cntr. UTHealth Grad. Sch. of Biomed. Sci., BHLHE40: Required for regulation of effector T cells and remodeling of tumor microenvironment during immune checkpoint therapy
  • Adam L. Burrack, Univ. of Minnesota, TNF-α blockade improves immunotherapy efficacy by altering the tumor microenvironment and enhancing tumor-specific T cell function in pancreatic ductal adenocarcinoma
  • Nathan E. Reticker-Flynn, Stanford Univ. Sch. of Med., Lymph node colonization promotes distant tumor metastasis through the induction of tumor-specific immune tolerance
  • Evelyn M. Nguyen, Mem. Sloan Kettering Cancer Ctr., Targeting LSD1 rescues MHC class I antigen presentation and promotes immune checkpoint blockade response in small cell lung cancer
  • Vishnu Modur, Cincinnati Children’s Hosp. Med. Ctr., Tumors bearing defective transcription elongation are immune hot but resistant to immune checkpoint inhibitors

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Technological Innovations in Immunology I

Chairs

  • Yuri Sykulev, Thomas Jefferson Univ.
  • Amanda M. Burkhardt, Univ. Southern California

Speakers

  • Yunhao Zhai, Wyss Inst. for Biologically Inspired Engin. at Harvard Univ., A human ectopic-lymphoid-follicle-on-a-chip for testing vaccines and adjuvants
  • Armando Javier Arroyo-Mejías, NIAID, NIH, 3D-IBEX: achieving multiplex 3-dimensional imaging for deep phenotyping of cells in tissues
  • Yuri Sykulev, Thomas Jefferson Univ., CD16 and NKG2D co-clustering facilitates quality of primary NK cell responses
  • Tim Le Fevre, STEMCELL Technologies, Inc., Generation of large numbers of functional NK cells without feeders or serum
  • Hing C. Wong, HCW Biologics, A feeder cell-free activation and expansion strategy to generate memory-like NK cells sufficient for off-the-shelf multi-dose adoptive cell therapy
  • Timothy C. Borbet, New York Univ. Sch. of Med., Leveraging mouse genetics to generate heavy-chain only antibodies for therapeutic application
  • Michael J.T. Stubbington, 10x Genomics, Discovery of potently-neutralizing antibodies against SARS-CoV-2 using Barcode Enabled Antigen Mapping (BEAM)

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Molecular Mechanisms of Cytokine Function

Chairs

  • Laurie E. Harrington, Univ. of Alabama at Birmingham
  • Gail Bishop, Univ. of Iowa

Speakers

  • Nicholas N. Jarjour, Univ. of Minnesota Med. Sch., Common gamma chain-dependent cytokines drive antigen-independent proliferation of circulating and resident memory CD8+ T cells
  • Rosanne Spolski, NHLBI, NIH, Distinct super-enhancer elements differentially control Il2ra gene expression in a cell-type specific fashion
  • Milos Vujanac, Univ. of Miami Miller Sch. of Med., Regulation of IL-2- and IL-6-dependent signaling in human Tregs by CISH and SOCS3
  • Emma Hornick, Univ. of Iowa, TRAF3 enhances type I interferon (IFN I) receptor signaling in T cells through modulation of the phosphatase PTPN22
  • Harold A. Silverman, Feinstein Institutes for Med. Research, Northwell Hlth., Transient receptor potential ankyrin 1 (TRPA1) mediates IL-1β-induced thermoregulation
  • Sonya Wolf, Michigan Med. at Univ. of Michigan, Interferon kappa (IFNk) in keratinocytes is critical for normal wound repair and is decreased in diabetic wounds
  • Emily A. Dennis, Univ. of Virginia, Loss of ten-eleven translocation 2 (TET2) reduces CCR6 expression and increases B1 B cell number in the peritoneal cavity
  • Audrey Kwun, Cleveland Clin. Fndn., Sustained NPSLE development in the absence of systemic lupus-like disease in TLR7-deficient B6.Nba2

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They Come and They Go: A Leukocyte Migration Extravaganza

Chairs

  • Judy Cannon, Univ. of New Mexico
  • Michael Gerner, Univ. of Washington

Speakers

  • Zev Joshua Greenberg, Washington Univ. in St Louis Sch. of Med., The tetraspanin CD53 as a novel regulator for B cell trafficking
  • Tonya Aaron, Albert Einstein Col. of Med., Inflammation depletes humoral immunity by limiting plasma cell access to the bone marrow survival niche
  • Paulus Mrass, Univ. of New Mexico, CXCR4 promotes the stop signal and degranulation of cytotoxic T cells infiltrating influenza-infected lungs
  • Farhat Parween, NIAID, NIH, CCR2 identifies two subtypes of pathogenic human type 17 Th cells and has a non-redundant role in their transendothelial migration
  • Wenji Piao, Univ. of Maryland Sch. of Med., PD-1 licenses activated Treg for lymphatic migration
  • Michael Y. Gerner, Univ. of Washington, Dendritic cells regulate innate cell trafficking into lymph nodes during inflammationM
  • Lai Wen, La Jolla Inst. for Immunology, A new β2 integrin activation reporter mouse reveals localized intra- and extra-vascular neutrophil integrin activation in vivo
  • Hemant Joshi, Washington Univ. in St. Louis Sch. of Med., Mechanical stress modulates NLRP3 pathway in macrophages

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Regulation of B and T Cells in Autoimmune Diseases

Chairs

  • Hubert M.Tse, Univ. of Alabama at Birmingham
  • Virginia Shapiro, Mayo Clin.

Speakers

  • Tracoyia A.Roach, Univ. of Florida, Lupus susceptibility gene pbx1 regulates stat3 in T cells via jak2/stat3 signaling pathway
  • Hu Zeng, Mayo Clin. Col. of Med. and Sci., mTORC2 contributes to murine lupus associated immunopathology
  • Anne B. Satterthwaite, Univ. of Texas Southwestern Med. Ctr., B cell subsets contributing to the autoreactive plasma cell pool in Lyn-/- mice
  • Samuel I. Blum, Univ. of Alabama at Birmingham, NADPH oxidase-derived superoxide promote autoreactive T cell infiltration into islets of prediabetic NOD mice
  • Stephanie J. Grebinoski, Univ. of Pittsburgh Sch. of Med., Intra-islet CD8+ T cells are restrained by an exhaustion program that can be partially reversed in the absence of LAG3
  • Alexander W. Boyden, Univ. of Iowa Carver Col. of Med., B cell-mediated antigen presentation is required to induce functional pathogenicity of CD4 T cells in a proteolipid protein mouse model of multiple sclerosis
  • Sydney B. Crotts, Mayo Clin., Regulation of inflammatory bowel disorder by ST8Sia6
  • Yuying Liu, McGovern Med. School, Univ. of Texas Hlth. Sci. Ctr. at Houston, Phenotype of CD39/CD73 expressed on T cells in a mouse model of IPEX syndrome

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Vaccines and Immunobiologics against Viruses

Chair

  • Fikadu G. Tafesse, Oregon Hlth. and Sci. Univ.

Speakers

  • Angela Desmond, Children’s Hosp. of Philadelphia, Preventing neonatal herpes: Protection after maternal mRNA-lipid nanoparticle vaccination equals or exceeds that from prior maternal genital infection in murine models
  • Ninaad Lasrado, Univ. of Nebraska-Lincoln, A live-attenuated mutant CVB3 vaccine virus protects against multiple coxsackievirus B infections
  • Laura Stephens, Univ. of Iowa, Robust efficacy and long-lasting humoral immunity induced by a respiratory syncytial virus prefusion F-based nanoparticle vaccine in genetically diverse animal models
  • Yinyan Xu, Univ. of North Carolina at Chapel Hill, Conserved-region MVA vaccines can shift HIV T cell immunodominance in PWH on ART—the M&M Study
  • Celeste Huaman, Uniformed Services Univ., Control of established, CNS-resident lyssavirus infection by an adaptive immune response stimulated by single-dose monoclonal antibody therapy
  • Husam Taher, Oregon Hlth. and Sci. Univ., T cell programming by the cytomegalovirus MHC class I homologue UL18
  • Ramireddy Bommireddy, Emory Univ. Sch. of Med., Influenza virus-like particle-based hybrid vaccine containing RBD induces immunity against influenza and SARS-CoV-2 viruses
  • Marta C. Cruz Cisneros, Univ. of North Carolina at Chapel Hill, Genetic analysis of differential responses to adjuvanted influenza vaccination

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Tumor Immunotherapy (TI1)

Chairs

  • Eduardo Davila, Univ. of Colorado
  • Beth Tamburini, Univ. of Colorado Anschutz Med. Campus

Speakers

  • Subir Biswas, Moffitt Cancer Ctr. and Res. Inst., CAR T cells targeting Olfactory Receptor OR2H1 are an effective immunotherapeutic option in human epithelial tumors
  • Jiemiao Hu, MD Anderson Cancer Ctr., Cell membrane-anchored and tumor-targeted IL-12 (attIL12)-T cell therapy for eliminating large and heterogeneous solid tumors
  • Colin J. Thalhofer, AgonOx Inc., Enriching for tumor-reactive CD8 TIL (AGX148) leads to effective tumor clearance in a patient-derived xenograph model
  • Joey C. Magno, Univ. of Colorado Anschutz Med. Campus, A novel linked TCR:MyD88 receptor improves anti-tumor responses while maintaining antigen specificity
  • Thomas Duhen, Earle A. Chiles Res. Inst., PD-1 and ICOS co-expression identifies tumor-reactive CD4 Th cells in human solid tumors
  • Kathryn M. Laporte, Univ. of Miami, Targeting the high-affinity IL-2R with high-dose mIL-2/CD25 induces effective antitumor responses
  • Silvia Guglietta, Med. Univ. of South Carolina, Complement downregulation promotes an inflammatory signature that renders colorectal cancer susceptible to immunotherapy
  • Paramita Chakraborty, Med. Univ. of South Carolina, Targeting autophagy with carbon-monoxide reprograms anti-tumor t cells with robust immunometabolic phenotype

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Immune-Based Therapeutics for Neurological Disease

Chairs

  • Giorgio Raimondi, Johns Hopkins Univ. Sch. of Med.
  • Andrea Castillo, Eastern Washington Univ.

Speakers

  • Md Jahirul Islam, Seoul Natl. Univ. Col. of Med., Non-classical anti-inflammatory drugs (NCAIDs) ameliorates brain inflammation and improves memory in Alzheimer’s diseases mice model
  • Jörg Wischhusen, Univ. Hosp. Wuerzburg, Alpha-synuclein peptides presented on chimeric MHC class Ib molecules prevent loss of substantia nigra neurons in an animal model for Parkinson’s disease
  • Kevin G. Senior, Univ. of Florida Col. of Med., Novel gene immunotherapy prevents Aquaporin-4 (AQP4) mediated neuroinflammation and demyelination in a mouse model of multiple sclerosis
  • Weikan Wang, Univ. of North Texas Hlth. Sci. Ctr., Aging impairs regulatory T cell (Treg) cells to affect late-onset (aged) multiple sclerosis (MS) – with the model of experimental autoimmune encephalomyelitis (EAE)
  • Daniel Hwang, Thomas Jefferson Univ., CSF-1 maintains pathogenic but not homeostatic myeloid cells in the central nervous system during autoimmune neuroinflammation
  • Javier Ochoa-Reparaz, Eastern Washington Univ., A GABA-producing probiotic for the protection of CNS demyelinating inflammation
  • Gaurav Kumar, Oklahoma Med. Res. Fndn., Deficiency in B Cell Maturation Antigen reveals sex differences in Experimental Autoimmune Encephalomyelitis
  • Giorgio Raimondi, Johns Hopkins Univ. Sch. of Med., Tolerogenic Artificial Antigen Presenting Cells for Selective Tolerance in Autoimmune Disease

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Memory T Cell Differentiation, Function, and Maintenance

Chairs

  • Nathan Schuldt, Univ. of Minnesota Med. Sch.
  • Yina Huang, Geisel Sch. of Med., Dartmouth Col.

Speakers

  • Terran D. Stenger, Univ. of Minnesota Med. Sch., Normal microbial experiences accelerate memory T cell compartment maturation in infants
  • Verena van der Heide, Icahn Sch. of Med. at Mount Sinai, Helpless CD8 T cell memory explained: prolonged antigen presentation drives a temporal rather than terminal defect
  • Taylor Heim, New York Univ. Langone Med. Ctr., CXCR6 is required for tissue resident memory T cell formation across diverse peripheral non-lymphoid tissues
  • Asmaa Mohamed, Geisel Sch. of Med., Dartmouth Col., Dendritic cells instruct differentiation of tissue resident memory T cells in the skin to promote durable tumor immunity
  • Henrique Borges da Silva, Mayo Clin., Cell-intrinsic expression of the hemichannel Pannexin-1 promotes effector and memory CD8+ T cells via distinct metabolic pathways
  • Daniel P. Caron, Columbia Univ. Med. Ctr., Human T cells in barrier sites exhibit site-specific characteristics and clonal compartmentalization
  • James R. Rose, Emory Univ. Sch. of Med., Epigenome accessibility changes before and after activation reveal distinct and progressive differentiation for human memory T cell subsets

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Immunoregulation—Mechanism of Action

Chairs

  • Rana Herro, Cincinnati Children’s Hosp. Med. Ctr.
  • Georges Helou, Univ. of Southern California

Speakers

  • Marina Ninkov, Univ. of Western Ontario, Canada, Chronic stress results in intrahepatic accumulation of a mononuclear myeloid-derived suppressor cell-like population
  • Temitayo Taiwo Bamgbose, Louisiana State Univ. Hlth. Sciences Ctr. at Shreveport, Lipin-1 restrains lipid synthesis to promote proresolving macrophage function and disease resolution
  • Carlos Alberto Mier Aguilar, Univ. of Alabama at Birmingham, Triggering receptor expressed on myeloid cells (Trem)-1 plays important roles in UVB induced immune suppression and cutaneous carcinogenesis
  • Pushpa Pandiyan, Case Western Reserve Univ., A new mechanism of Treg cell dysfunction during HIV infection and propensity to oral cancer in people living with HIV
  • Mohammad Nizam Mansoori, NIAID, NIH, Tregs suppress antigen-specific CD8+ T cells in vivo by depleting pMHC-I complexes from dendritic cells
  • Shaikh M. Atif, Univ. of Colorado Anschutz Med. Campus, Protective role of tissue-resident regulatory T cells in a murine model of beryllium-induced disease
  • Shokofeh Rahimpour, West Virginia Univ., A potential monocyte-regulatory T cell axis in neurorestoration following ischemic stroke