Block Symposia

Full Listing

Tuesday, May 10, 2022 10:15 AM – 12:15 PM Room C123–124

Adaptive Immunity in Inflammation

Chairs

Anne Satterthwaite, UT Southwestern Med. Center
Joshua Gray, Columbia Univ. Med. Ctr.

Speakers

Carlo Vanz, Univ. of Texas Hlth. at San Antonio, Dysfunction in B cell tolerance and activation in obesity
Julio Molineros, Janssen Res. and Devel., Leveraging genetic correlation across immune-mediated disease to gain insights into underpowered studies of rare conditions
Ana C. Costa da Silva, NIDCR, NIH, Pathogenic tissue-resident memory T cells in exocrine gland chronic graft-versus-host disease
Laure Campillo-Gimenez, Univ. of California, San Diego, Evidence for metabolic disturbances in the pathogenesis of immune-mediated disease in SAMP1/YitFcs Mice
Michael A. Silverman, Perelman Sch. of Med., Univ. of Pennsylvania, IgA deficiency destabilizes immunological homeostasis towards intestinal microbiota and increases the risk of systemic immune dysregulation
Swarna Beesetti, St. Jude Childrens Res. Hosp., Targeting the NLRP3 inflammasome in Rare hereditary blood disorder Fanconi Anemia
Yingcong Li, Univ. of California, San Diego, From genetic variants to diseases: the role of LACC1 in T cells

Friday, May 6, 2022 2:00 PM – 4:00 PM Room A107–109

Antigen Processing and Presentation I

Chairs

Laura Santambrogio, Weill Cornell Med.
Malini Raghavan, Univ. of Michigan

Speakers

Zhixin Jing, Albert Einstein Col. of Med., Germinal center expansion but not plasmablast differentiation is directly proportional to peptide-MHCII density via CD40-CD40L signaling strength
Adam L. Burrack, Univ. of Minnesota, Distinct myeloid antigen presenting cells dictate differential fates of tumor-specific CD8 T cells in pancreatic cancer
Laura Santambrogio, Weill Cornell Med., Metabolic insults elicit epitope-dependent immune autoreactivity aggravating hepatic damage in type 2 diabetes
Padma Pandurang Nanaware, Univ. of Massachusetts Chan Med. Sch., Profiling MHC-I and MHC-II canonical and out-of-frame epitopes from SARS-CoV-2 and seasonal human coronavirus infected human cells
Katheryn M. Wininger, Mayo Grad. Sch. of Biomed. Sci., Dissecting the role of H-2Db class I molecule in the development of brain atrophy during Theiler’s murine encephalomyelitis virus (TMEV) infection
Jiansheng Jiang, NIAID, NIH, Mechanism of Peptide Loading as Revealed by Structure of tapasin/MHC-I Complex
Julie Dobkin, Rutgers State Univ. of New Jersey, Investigating the potential binding partners of H2-O to further elucidate its role in MHCII antigen presentation

Tuesday, May 10, 2022 8:00 AM – 10:00 AM Room A107–109

Antigen Processing and Presentation II

Chairs

Lisa Denzin, Rutgers Univ. New Jersey Med. Sch.
Paul Roche, NCI,NIH

Speakers

Ashley M. Curran, Johns Hopkins Univ. Sch. of Med., Citrullination modulates MHC class II antigen processing and presentation by revealing cryptic epitopes
Camille Lake NIAID, NIH, Sequence similarity between SARS-CoV-2 Nucleocapsid and CNS proteins provides mechanistic insight into viral neuropathogenesis following infection
Jiangyuan Li, NIA, NIH, Repertoire size and predictability of influenza A virus matrix protein (M1_58-66)-specific CD8⁺ TCR
Swati Jaiswal, Univ. of Massachusetts Chan Med. Sch., Reverse Immunology: An approach to identify Mtb antigens recognized by T cells
Cori E. Fain, Mayo Clin., H-2Kb and H-2Db class I molecules on cerebral endothelium differentially modulate CD8 T cells dynamics and pathological outcomes in experimental cerebral malaria
Daniel Kyle Taylor, NIAID, NIH, Dynamic features of tapasin as revealed by structures of two tapasin/Fab complexes
Kahoko Hashimoto, Chiba Inst. of Technol., Autophagy in antigen presenting cells enhances the adjuvant effect by promoting antigen processing.
Shaodong Dai, Univ. of Colorado Anschutz Med. Campus, T cell recognition of disulfide modified antigens

Saturday, May 7, 2022 3:45 PM – 5:45 PM Room B110–112

Autoantigen Identification, Autoantigen Specificity, and Central Tolerance

Chairs

Maria Bettini, Univ. of Utah Sch. of Med.
Kristin Hogquist, Univ. of Minnesota

Speakers

Mekha A. Thomas, Johns Hopkins Univ. Sch. of Med., The monocyte cell surface as a novel site of autoantigen generation in Rheumatoid Arthritis
Mianmian Yin, Univ. of California, San Francisco, Autoantigen specific T-cell receptor induces organ-specific autoimmunity by escaping T cell negative selection
Alexander J. Dwyer, Univ. of Minnesota, CD4⁺ T cells targeting a hybrid insulin: chromogranin A self-antigen are necessary and sufficient for autoimmune diabetes initiation
Yi Jing, Baylor Col. of Med., Insulin specific TCR repertoire analysis reveals functional diversity of Treg TCRs
Paul Zdinak, Univ. of Pittsburgh Sch. of Med., Profiling transcriptomes, TCR repertoires, and antigenic specificities of islet-infiltrating T cells in non-obese diabetic mice
Jun Hyung Sin, Univ. of California, San Francisco, Control of medullary thymic epithelial cell development and central tolerance by a zinc finger transcription factor
Ryan J. Martinez, Univ. of Minnesota, Type III interferon enhances thymic B cell licensing
Gregory J. Tsay, China Med. Univ., A specific 25-mer peptide from the cysteine protease of P. gingivalis is the epitope of humoral immune response in rheumatoid arthritis

Saturday, May 7, 2022 10:15 AM – 12:15 PM Oregon Ballroom 203

Autoimmunity

Chairs

Veena Taneja, Mayo Clin.
Hsin-Jung Wu, The Ohio State Univ. Col. of Med.

Speakers

Jacob William Shelton Martens, Univ. of Michigan, The role of skin-derived IFN-kappa in the development of systemic autoimmunity
Jonathan D. Crawford, Johns Hopkins Univ. Sch. of Med., XIST is a source of TLR7 ligands underlying the sex bias in Systemic Lupus Erythematosus
Nirmal K. Banda, Univ. of Colorado Anschutz Med. Campus, A snap shot of complement gene expression and presence of complement proteins in synovial biopsies from early rheumatoid arthritis patients
Diego A. Espinoza, Perelman Sch. of Med., Univ. of Pennsylvania, Proteogenomic immune signatures delineate the landscape of pediatric acquired demyelinating syndromes
Bonnie Blomberg, Univ. of Miami Miller Sch. of Med., Old mice and elderly humans make increased autoimmune antibodies, inflammation and SASP from aged-increased B cells (ABCs in mice and DN in humans) which are hypermetabolic
Sarah Alice Long, Benaroya Res. Inst., CD8 T cell exhaustion is reduced in subjects with autoimmune-associated DR4 risk alleles
Adebowale Bamidele, Mayo Clin. Rochester, Metabolic dysfunction governs regulatory t cell inflammatory response during inflammatory bowel disease
Alice E. Wiedeman, Benaroya Res. Inst., Differential therapeutic modulation of exhaustion among autoreactive and global CD8 T cells in type 1 diabetes (T1D)

Saturday, May 7, 2022 3:45 PM – 5:45 PM Room B117–119

B and T Cell Development

Chairs

Ann Griffith, Univ. of Texas Hlth. Sci. Ctr. San Antonio
Neetu Gupta, Cleveland Clin.

Speakers

Sarah A. Wedemeyer, Univ. of Texas Hlth. Sci. Ctr. at San Antonio, Role of paracrine mTOR signaling in regulating thymus size and function
Katherine Maude Ashby, Univ. of Minnesota, Thymic interferon impacts T cell selection
Tom N. Taghon, Ghent Univ., Belgium, An unexpected role for IRF8 during human T cell development
Breanna P. Caruso, Oregon Hlth. & Sci. Univ., A lineage specific role for PD-1 in agonist selection in the thymus
Jonathan E. Boyson, Univ. of Vermont, Single-cell proteogenomics reveals that SLAM/SAP signaling regulates the development of innate-like γδ T cell subsets with distinct TCR repertoires
Varun Aysola, Cleveland Clin., Ezrin promotes antigen receptor diversity during B cell development by supporting immunoglobulin heavy chain variable gene recombination
Michael Jonathan Lehrke, Mayo Clin., ABCB7 is required for B cell development, proliferation, and class switch recombination

Sunday, May 8, 2022 8:00 AM – 10:00 AM Oregon Ballroom 202

B Cell and T Cell Helper Responses during Viral Infections

Chairs

Akiko Iwasaki, Yale Sch. of Med.
Henrique Borges da Silva, Mayo Clin.

Speakers

Henrique Borges da Silva, Mayo Clin., Establishment of influenza-specific lung tissue-resident helper memory CD4⁺ T cells relies on expression the eATP sensor P2RX7
E. Taylor Stone, St. Louis Univ, Sch. of Med., Requirement for robust T and B cell responses for immune protection against Powassan virus (POWV) in virus-like particle (VLP) vaccination
Christopher Ned Jondle, Med. Col. of Wisconsin, T cell-intrinsic IL-17RA signaling in the spleen supports the establishment of chronic gammaherpesvirus infection
Yexin Yang, Yale Sch. of Med., Glycan-specific B-1 cells mediate blockade of endogenous retroviruses emergence through recognition of conserved glycan epitopes
Antonio Cembellin Prieto, Univ. of California, Davis, B cell-derived acetylcholine controls local inflammation and replication of influenza virus during respiratory tract infections
Jalene V. Velazquez, Washington State Univ., Distinct antibody profiles against Ebola virus track with the development of Post-Ebola Syndrome.
Ariana Denise Campbell, Johns Hopkins Bloomberg Sch. of Public Hlth., Influenza A virus-specific maternal antibodies impair vaccine-induced antibody responses and protection in male to a greater extent than female offspring
Jenna Guthmiller, Univ. of Chicago, B cell convergence to distinct broadly reactive epitopes revealed by chimeric hemagglutinin vaccination

Tuesday, May 10, 2022 8:00 AM – 10:00 AM Room B117–119

B Cell Differentiation, Regulation, and Function

Chairs

Thomas Forsthuber, Univ. of Texas San Antonio
Ginny L. Bumgardner, The Ohio State Univ. Med. Ctr.

Speakers

Juan Marcos Oviedo, Univ. of Utah, IL-4 Signaling Regulates the Fate of B Cell Differentiation and limits BCR repertoire
Jason M. Zimmerer, Wexner Med. Ctr., Ohio State Univ., Optimal development and effector function of antibody-suppressor CXCR5⁺CD8⁺ T cells requires host IFN-γ and CD4⁺ T cells
Sarah E. Webster, Western Michigan Univ. Homer Stryker MD Sch. of Med., Let's talk about sex, baby: sex influences age-related changes in natural antibodies and natural antibody producing B-1a cells
Austin Joseph Negron, Univ. of Texas San Antonio, The role of ERK2 in regulating germinal center B cell fate decisions
Amit K. Singh, NIA, NIH, Unique and shared molecular features of human B and T lymphocyte memory differentiation
James Knox, Perelman Sch. of Med., Univ. of Pennsylvania, Splenic T-bet⁺ B cells exhibit stem-like features and constitutively generate antibody-secreting cells

Sunday, May 8, 2022 8:00 AM – 10:00 AM Room B113–116

Big Data: The Key to Unlocking Immune Mediated Mechanisms of Tumor Progression and Therapy Response

Chairs

Mary Philip, Vanderbilt Univ. Med. Ctr.
Sepideh Dolatshahi, Univ. of Virginia

Speakers

Joshua Brand, Univ. of Wisconsin-Madison, Single-cell myeloid diversity in human fallopian tube and its implications for early high grade serous ovarian cancer
Nicola S. Meagher, Univ. of New South Wales, Multi-modal immune profiling of mucinous ovarian carcinoma: analysis from the Ovarian Tumor Tissue Analysis/Multidisciplinary Ovarian Cancer Outcomes Group consortia
Mieszko Lachota, Med. Univ. of Warsaw, Analysis of chemokine network in primary human glioblastoma
Cristina F. Contreras, NCI, NIH, Transcriptomic and epigenetic profiling of tumor-associated monocyte function
Huy Dinh, Univ. of Wisconsin-Madison, Defining myeloid plasticity and heterogeneity in immunotherapy response
Vivien Ileana Maltez, NIAID, NIH, Multiplex microscopy reveals unique spatiotemporal effects of cancer immunotherapies
William L. Redmond, Earle A. Chiles Res. Inst., Multimodal single-cell analysis of human TILs across multiple tumor types reveals heterogeneity and potential opportunities for personalized immunotherapy
Abigail L. Sedlacek, Univ. of Pittsburgh, Identification of immunogenic peptide neoantigens expressed in sarcomas and their therapeutic potential

Monday, May 9, 2022 8:00 AM – 10:00 AM Room C123–124

CD4⁺ T Cell Regulation and Responses: Molecular Mechanisms

Chairs

Claire Chougnet, Cincinnati Children's Med. Ctr.
Tammy Kielian, Univ. of Nebraska Med. Ctr.

Speakers

Laura Melissa Atehortua, Cincinnati Children's Hosp. Med. Ctr., Apolipoprotein E enhance survival of effector memory regulatory T lymphocytes by regulating caspase-dependent apoptosis and lipid metabolism
Gunjan Kak, Univ. of Nebraska Med. Ctr., Th1 and Th17 cells are critical for limiting the severity of Staphylococcus aureus craniotomy infection
Ying Ding, Miller Sch. of Med., Univ. of Miami, Blimp1 regulates the growth and function of human regulatory T cells
Cody Mowery, Gladstone Inst., CRISPR-based functional genomics to decode cis and trans regulation of the CD28, CTLA4, and ICOS costimulatory locus
Duy Pham, Univ. of Alabama at Birmingham, Sch. of Med., Batf stabilizes the th17 cell developmental program through impairment of stat5-dependent recruitment of Ets1-Runx1 complexes
Michelle Chu, Indiana Univ. Sch. of Med., TL1A promotes a multi-cytokine Th9 cell phenotype
Wesley H. Godfrey, Johns Hopkins Univ. Sch. of Med., Inhibition of distinct glycolytic enzymes produces differential effects on CD4 T cell function
Dean R. Tantin, Univ. of Utah Sch. of Med., Transcription coactivator OCA-B/Pou2af1 is necessary and sufficient to promote T cell-intrinsic CD4 memory

Sunday, May 8, 2022 3:45 PM – 5:45 PM Room A105–106

CD4⁺ T Cells in Cancer

Chairs

Stephen Schoenberger, La Jolla Inst. for Immunology
Steven Ziegler, Benaroya Res. Inst.

Speakers

Spencer E. Brightman, La Jolla Inst. for Immunology, TCR-engineered neoantigen-specific CD4⁺ T cells mediate immunotherapy of a class II-negative murine squamous cell carcinoma
Katelyn T. Byrne, Perelman Sch. of Med., Univ. of Pennsylvania, CD4⁺ T cells mediate non-canonical rejection of major histocompatibility class-I deficient pancreatic tumors independently of CD8⁺ T cells
Dan Chen, Salk Inst. for Biological Studies, Dissecting anti-tumor immunity in glioblastoma
Ying Zheng, Johns Hopkins Univ. Sch. of Med., Target the activin receptor 1c on CD4⁺ T cells to achieve anti-tumor therapeutic effects
Hsin Yu Liu, La Jolla Inst. for Immunology, Leveraging the Treg-intrinsic CTLA4-PKCη signaling pathway for cancer immunotherapy
Kazushige Obata-Ninomiya, Benaroya Res. Inst., Virginia Mason, Thymic stromal lymphopoietin (TSLP) receptor signaling controls a tumorigenic Treg to promote colorectal cancer
Kai Yang, Indiana Univ. Sch. of Med., The glutathione peroxidase Gpx4 prevents Treg lipid peroxidation and ferroptosis to facilitate tumor immunoevasion

Sunday, May 8, 2022 3:45 PM – 5:45 PM Oregon Ballroom 201

CD8⁺ T Cell Immunity to Viral Infections

Chairs

Benjamin Youngblood, Saint Jude Children's Res. Hosp.
Erietta Stelekati, Miller Sch. of Med., Univ. of Miami

Speakers

Blair K. Hardman, Univ. of British Columbia, Differential localization and kinetics of antiviral CD8⁺ T cell responses to chronic and acute murine norovirus infections from initiation onwards
Jia Zhu, Univ. of Washington, In situ characterization of lesion-forming human HSV-2 reactivation reveals distinct innate and adaptive immune compartmentalization
Adolfo B. Frias, St. Jude Children's Res. Hosp., HIV-specific CD8⁺ T cells from elite controllers have an epigenetic imprint that preserves effector functions
Blake Torrance, UConn Hlth., Role of p16 expressing cells in formation and function of T cell memory with age
Xuebing Leng, Miller Sch. of Med., Univ. of Miami, MicroRNA-29a attenuates exhaustion and promotes memory-like CD8⁺ T cells
Genevieve N. Mullins, Univ. of North Carolina at Chapel Hill, CD8⁺ T cell exhaustion is dynamically controlled by the chromatin regulator factor BRD4
Roman Khadka, Mayo Clin., A novel approach to define contribution of microglia and brain endothelium in antigen specific CD8⁺ T cell-mediated blood brain barrier (BBB) disruption during virus infection
Jennifer Berger, Univ. of Colorado Anschutz Med. Campus, A unique gammadelta T cell population in the brain during viral infection

Monday, May 9, 2022 3:45 PM – 5:45 PM Oregon Ballroom 201

CD8⁺ T Cells in Cancer

Chairs

Andrea Schietinger, Memorial Sloan Kettering Cancer Ctr.
David Masopust, Univ. of Minnesota

Speakers

Michael William Rudloff, Vanderbilt Univ. Med. Ctr., Hallmark features of T cell dysfunction are established within hours after tumor antigen encounter
Nataliya Prokhnevska, Emory Univ., CD8 T cell activation in cancer is comprised of two distinct phases
Hazem E. Ghoneim, Ohio State Univ. Col. of Med., Rebalancing TGFβ1/BMP Signaling Epigenetically Reprograms Fully Exhausted Human CD8 T Cells into a Functional State
Benjamin M. Murter, Univ. of Pittsburgh Sch. of Med., PIK3IP1/TrIP Immune Regulation on CD8⁺ T Cells Restricts Anti-Tumor Immunity
Rachel Cantrell, Univ. of Cincinnati Col. of Med., The role of the Thrombin/PAR axis in modulating CD8+ T cell anti-tumor immunity
Haitao Wen, Ohio State Univ., Sushi domain containing 2 suppresses CD8⁺ T cell antitumor immunity by targeting IL-2 receptor signaling
Emily C. Lerner, Duke Univ. Sch. of Med., CD8 T cells licensed with immune checkpoint blockade kill murine tumors lacking MHC-I
Pamela Rosato, Geisel Sch. of Med., Dartmouth Col., Functional virus-specific memory CD8+ T cells survey glioblastoma

Tuesday, May 10, 2022 10:15 AM – 12:15 PM Room A107–109

Cells of the Innate Immune System

Chairs

Maninjay Atianand, Univ. of Pittsburgh
Dimitry Krementsov, Univ. of Vermont

Speakers

Sarah J. Sun, Univ. of Chicago, BCG vaccination impacts the epigenetic landscape of progenitor cells in human bone marrow
Dimitry N. Krementsov, Univ. of Vermont, LncRNA U90926 is induced in activated macrophages, encodes a novel secreted protein, and is protective in endotoxic shock
Kevin E. Vergara, Univ. of Pittsburgh Sch. of Med., The long noncoding RNA LUCAT1 promotes immune gene expression in human macrophages
Oscar A. Aguilar, Univ. of California, San Francisco, CD3ζ adaptor structure determines functional differences between human and mouse CD16 Fc-gamma receptor signaling in natural killer cells
Fernando Souza-Fonseca-Guimaraes, Univ. of Queensland Diamantina Inst., TGF-β and CIS inhibition synergistically enhance natural killer cell-based immunity
Zhenyu Zhong, Univ. of Texas Southwestern Med. Ctr., dNTP catabolism is a macrophage-intrinsic gatekeeper preventing NLRP3 inflammasome hyperactivation
Heather L. Caslin, Vanderbilt Univ., Do adipose macrophages remember obesity? Innate immune memory in weight cycling

Tuesday, May 10, 2022 8:00 AM – 10:00 AM Room C123–124

Cytokine and Chemokine Control of Cellular Immunity

Chairs

Thomas Malek, Miller Sch. of Med., Univ. of Miami
Robert Welner, Univ. of Alabama at Birmingham

Speakers

Sergio Pontejo, NIAID, NIH, Chemokines and anionic phospholipids: new binding partners for microbial killing and apoptotic cell clearance
Haressh Sajiir, Mater Res. Inst., Univ. of Queensland, Pancreatic interleukin-22 receptor signaling is critical in maintaining beta-cell insulin production and is hepatoprotective
Victoria Matkins, Univ. of Alabama at Birmingham, Perturbations of Marrow Stromal Cell function during Acute Inflammation
Elizabeth M. Hill, Univ. of Maryland Sch. of Med., Collaboration of therapeutic, systemic IL12p40 with locally released IL12p35 focuses immunity to the tumor microenvironment
Marine Rousseau, Université de Montréal, Characterization of a new cytokine complex from the IL-6/IL-12 family
Rebecca Martin, Virginia Commonwealth Univ. Sch. of Med., Loss of ADAM17 from macrophages induces ST2⁺ T regulatory cells that limit obesity-induced metabolic inflammation in mice through changes in both membrane and soluble TNF
Acaci Crouch, Univ. of Miami Leonard M. Miller Sch. of Med., Interleukin-2 signaling engages de novo cholesterol biosynthesis in regulatory T cells

Monday, May 9, 2022 10:15 AM – 12:15 PM Room A105–106

Cytokine and Regulatory Cell Control of Autoimmunity

Chairs

Ziaur Rahman, Pennsylvania State Univ. Col. of Med.
Edwin Wan, West Virginia Univ.

Speakers

Ivy L. Debreceni, Univ. of Iowa, IL-27 signaling contributes to pathogenic T cells in a mouse model of Sjögren's
Gabriel Arellano,Northwestern Univ., Interferon-gamma controls pathogenic T-helper 17 and B cells in a new Aquaporin-4 induced experimental autoimmune encephalomyelitis
Tse-Hua Tan, Natl. Hlth. Res. Inst., MAP4K3/GLK is a novel therapeutic target for IL-17A-mediated autoimmune diseases
Kelly Lynn Monaghan, West Virginia Univ., Sch. of Med., Tetramerization of STAT5 promotes autoimmune-mediated neuroinflammation
Mianmian Yin, Univ. of California, San Francisco, Development of uveitis in a mouse model of spontaneous autoimmunity correlates with frequency of autoantigen-specific regulatory T cells
Seung-Chul Choi, Univ. of Florida, Homeodomain protein Pbx1 regulates regulatory T cell development, stability and suppressive function
Ulus Atasoy, Michigan Med. at Univ. of Michigan, Treg-specific ablation of HuR results in systemic autoimmunity associated with decreased TLR4 activation and IL-1β production
Sarah Pasquin, Université de Montréal, Canada, Investigating immune tolerance: characterization of immunoregulatory DN T cells

Saturday, May 7, 2022 8:00 AM – 10:00 AM Oregon Ballroom 201

Engineering Immunoreceptor and Cytokine Signaling for Therapeutics

Chairs

Ingunn Stromnes, Univ. of Minnesota
Carl Ware, Sanford Burnham Prebys Med. Discovery Inst.

Speakers

Nina Beryl Horowitz, Stanford Univ., Overcoming barriers to solid tumor immunotherapy using natural killer cell therapies designed to mimic intraepithelial group 1 innate lymphoid cells
Meagan R. Rollins, Univ. of Minnesota Med. Sch., Adoptive transfer of Trac-targeted T cell receptor engineered T cells with defective Tgfbr2 signaling promotes pancreatic cancer eradication
Karen Michelle Christie, Univ. of Delaware, Directing T cell alloreactivity against solid tumors through tumor antigen dependent TCR expression
Zachariah Peter Tritz, Mayo Clin. Grad. Sch. of BioMed. Sci., Combination of αPD-1 and extended half-life IL-2 is effective against the GL261 glioma and uniquely reverses GBM-associated immunosuppression
Travis J. Shute, UT Hlth. San Antonio, Glycolipid-loaded nanoparticle immunotherapy cooperates with checkpoint inhibitors to harness iNKT cells for tumor control
Aliyah Brianne Silver, Johns Hopkins Bloomberg Sch. of Public Hlth., A tumor-targeted cytokine/antibody fusion protein to stimulate anti-cancer immunity
Kyle Alexander Romine, Oregon Hlth. and Sci. Univ., BET inhibitors synergize with anti-PD1 by rescuing TCF1+ progenitor exhausted T cells in acute myeloid leukemia
Hien T. Huynh, Univ. of Missouri Columbia, Dissecting molecular mechanisms underlying T cell co-potentiation when targeting the TCR/CD3 complex with anti-CD3 Fab fragments

Monday, May 9, 2022 10:15 AM – 12:15 PM Oregon Ballroom 202

Food Allergy, Atopic Dermatitis, and Mast Cells, Oh My!

Chairs

Mark Kaplan, Indiana Univ. Sch. of Med.
Adrian Piliponsky, Seattle Children's Res. Inst.

Speakers

Lauren A. Hesser, Univ. of Chicago, Developing a synbiotic biotherapy to prevent allergic responses to food
Nada Salem Alakhras, Indiana Univ. Sch. of Med., Covalent heterobivalent inhibitor effectively inhibits anaphylaxis to peanut allergen in a humanized mouse model
Clinton B. Mathias, Western New England Univ., Interleukin-10 enhances IL-33-mediated MC activation and modulates the development of food allergy
Irina Miralda Molina, Seattle Children's Res. Inst., Ligation of Siglec- 9 inhibits FcεRI-dependent mediator release from human mast cells
Tamara Salloum, Brigham and Women’s Hosp. and Harvard Med. Sch., Transcriptional profiling unveils the heterogeneity of constitutive and inducible mast cells in inflammation and homeostasis
Adam James Moeser, Michigan State Univ., Androgen receptor deficiency eliminates sex differences in mast cells
Chang-hyun Kim, Vigencell Inc., Immunomodulatory effects of human myeloid-derived suppressor cells expanded from cord blood on dermatophagoides farinae-induced atopic dermatitis in NC/Nga mice
Brandon Lee, MIT, Novel association of lyme disease, age, and atopic dermatitis

Saturday, May 7, 2022 8:00 AM – 10:00 AM Room A107–109

From Sharks, Fish, and Frogs to Mammals: Fascinating Immunological Discoveries

Chairs

Renukaradhya Gourapura, The Ohio State Univ.
Rob Miller, Univ. of New Mexico

Speakers

Aryana Razmara, Univ. of California, Davis, Optimization of expansion techniques for adoptive NK cell transfer in dogs with cancer
Kimberly A. Morrissey, Univ. of New Mexico, The biology of the unconventional γμ T cell in the opossum Mondodelphis domestica
Renukaradhya J. Gourapura, Ohio State Univ., Plant derived Nano-11 particle adsorbed with stimulator of interferon genes adjuvant and split influenza virus antigens elicits the cross-protective immunity in pigs
Jordan M. Sampson, Univ. of New Mexico, B cell ontology in a model marsupial
Ahmed Attaya, Univ. of Massachusetts Lowell, scRNA-Seq profiling of stickleback fish splenocytes: expansion of myeloid and B cells on immunization
Matthieu Paiola, Univ. of Rochester Med. Ctr., Flt3 and its ligand as an ancient regulators of dendritic cells: evidence in the amphibian Xenopus laevis
Hanover C. Matz, Univ. of Maryland, Baltimore, B cell selection sites in the nurse shark spleen may represent evolutionary precursors of mammalian germinal centers
Yvonne Drechsler, Western Univ. of Hlth. Sci., Characterization of cellular subpopulations and their gene expression by single-cell RNA sequencing in canine atopic dermatitis

Friday, May 6, 2022 2:00 PM – 4:00 PM Room B117–119

HSCs and Myelopoiesis

Chairs

Anna Beaudin, Sch. of Med., Univ. of Utah
Jeffrey Bednarski, Washington Univ. Sch. of Med.

Speakers

Stephanie Crowley, Washington Univ. Sch. of Med., Bclaf1 promotes hematopoietic stem cell repopulating capacity and self-renewal
Momoko Yoshimoto, McGovern Med. School, Univ. of Texas Hlth. Sci. Ctr. at Houston, HSC-independent definitive lymphopoiesis persists into adult life
Jennifer E. Howard, Albany Med. College, IL-18R signaling impairs hematopoietic recovery after severe, shock-like infection
Marion Lacroix, IRCM, The X-linked gene for the helicase DDX3X is required for lymphoid differentiation and MYC-driven lymphomagenesis
Betsabel J. Chicana, Sch. of Natural Sci., Univ. of California Merced, Vhl deficiency in Dmp1-expressing cells affects myeloid development and erythropoiesis: possible effects on myeloerythroid metabolism
Tiantian Liu, Washington Univ. Sch. of Med. in St. Louis, Ablation of cDC2 lineage specification by mutations within the δ−165 kb Zeb2 enhancer
Jayashree Srinivasan, Univ. of Texas at Austin, Cellular and molecular mediators of thymic DC homeostasis and activation
Diego A. Lopez, Univ. of Utah Sch. of Med., Maternal immune activation (MIA) impairs neonatal lung ILC2 establishment, function, and airway hyperresponsiveness

Friday, May 6, 2022 2:00 PM – 4:00 PM Room B113–116

Immune-Based Therapeutics for Neurological Disease

Chairs

Giorgio Raimondi, Johns Hopkins Univ. Sch. of Med.
Andrea Castillo, Eastern Washington Univ.

Speakers

Md Jahirul Islam, Seoul Natl. Univ. Col. of Med., Non-classical anti-inflammatory drugs (NCAIDs) ameliorates brain inflammation and improves memory in Alzheimer’s diseases mice model
Jörg Wischhusen, Univ. Hosp. Wuerzburg, Alpha-synuclein peptides presented on chimeric MHC class Ib molecules prevent loss of substantia nigra neurons in an animal model for Parkinson's disease
Kevin G. Senior, Univ. of Florida Col. of Med., Novel gene immunotherapy prevents Aquaporin-4 (AQP4) mediated neuroinflammation and demyelination in a mouse model of multiple sclerosis
Weikan Wang, Univ. of North Texas Hlth. Sci. Ctr., Aging impairs regulatory T cell (Treg) cells to affect late-onset (aged) multiple sclerosis (MS) – with the model of experimental autoimmune encephalomyelitis (EAE)
Daniel Hwang, Thomas Jefferson Univ., CSF-1 maintains pathogenic but not homeostatic myeloid cells in the central nervous system during autoimmune neuroinflammation
Javier Ochoa-Reparaz, Eastern Washington Univ., A GABA-producing probiotic for the protection of CNS demyelinating inflammation
Gaurav Kumar, Oklahoma Med. Res. Fndn., Deficiency in B Cell Maturation Antigen reveals sex differences in Experimental Autoimmune Encephalomyelitis
Giorgio Raimondi, Johns Hopkins Univ. Sch. of Med., Tolerogenic Artificial Antigen Presenting Cells for Selective Tolerance in Autoimmune Disease

Tuesday, May 10, 2022 10:15 AM – 12:15 PM Room B117–119

Immunity to Microbial, Parasitic, and Fungal Infections I

Chairs

Olandrewaju Morenikeji, Univ. of Pittsburgh at Bradford
Denise Monack, Stanford Univ. Sch. of Med.

Speakers

Yogesh Scindia, Univ. of Florida, Hepcidin deficiency increases susceptibility to disseminating candidiasis and renal failure
Claire Depew, Univ. of California, Davis, Sterile liver inflammation and T cell-intrinsic T-bet expression drive the formation of Tissue Resident Memory CD4 T cells that protect against systemic Salmonella infection
Erinn L. Donnelly, Univ. of Idaho, Basophil depletion alters host immunity, intestinal permeability and mammalian host-to-mosquito transmission in malaria
Javeed A. Shah, Univ. of Washington, The tuberculosis resistance protein TOLLIP prevents disease progression by regulating the integrated stress response in alveolar macrophages.
Andrew Thomas Martin, Univ. of Rochester Med. Ctr. Selective reprogramming of peritoneal macrophages by IFN-γ during acute Toxoplasma gondii infection
Teri Hreha, Washington Univ. in St Louis Sch. of Med., Androgen exposure alters the neutrophil response to pyelonephritis
Yanli Chen, Univ. of Maryland, Col. Park, TNF-α signaling is required for fungal clearance during brain infection with Cryptococcus neoformans via promoting the recruitment of CD4⁺ T cells and inflammatory monocytes
Brandon Keith Wilder, Oregon Hlth. and Sci. Univ., Malaria antigens are presented to CD8 T cells via the non-classical HLA-E

Saturday, May 7, 2022 12:30 PM – 2:30 PM Room B113–116

Immunity to Microbial, Parasitic, and Fungal Infections II

Chairs

De'Broski Herbert, Univ. of Pennsylvania Sch. of Vet. Med.
Tracey Lamb, Univ. of Utah

Speakers

Jenna Reed, Univ. of Utah Sch. of Med., Plasmodium infection elevates risk of severe secondary bacterial disease by altering the immunological landscape of the lung
Oscar Rosas Mejia, Ohio State Univ. Col. of Med., Mice infected with Mycobacterium tuberculosis are resistant to secondary infection with SARS-CoV-2
Nicolas Olive Jean Millet, Harbor-Univ. of California, Los Angeles Med. Cntr., IL-23 signaling limits ferroptosis-driven immunopathology during systemic fungal infection
Trung Hoang Minh Pham, Stanford Univ. Sch. of Med., Single-cell profiling identifies ACE⁺ granuloma macrophages as a non-permissive niche for intracellular bacteria during persistent Salmonella infection
Yazmin Berenice Martinez-Martinez, Univ. of Texas Med. Br. at Galveston, HIV compromises Th17 and Th22 immunity in a humanized mouse model of Tuberculosis and HIV co-infection
E. Evonne Jean, Univ. of Pennsylvania Sch. of Vet. Med., Exploring cutaneous neuro-immune networks during helminth infection
Nana K. Minkah, Seattle Childrens Res. Inst., Type I Interferon remodels intrahepatocytic signaling to promote T cell dysfunction during liver stage Plasmodium infection
Romaniya Zayats, Univ. of Manitoba, Cellular dynamics of immune evasion during Leishmania major infection

Saturday, May 7, 2022 12:30 PM – 2:30 PM Oregon Ballroom 201

Immunity to SARS-CoV-2

Chairs

Emily Hemann, The Ohio State Univ., Col. of Med.
Paul Thomas, Saint Jude Children's Res. Hosp.

Speakers

Abigail Solstad, Ohio State Univ., Endogenous interferon-lambda signaling restricts virus replication and disease severity in a murine model of SARS-CoV-2 infection
Jodi F. Hedges, Montana State Univ., ADAM-17 protease promotes inflammation and mortality while decreasing viral burden in a COVID-19 mouse model
Xiao He, Univ. of Utah, A longitudinal study of humoral immune responses to SARS-CoV-2 spike proteins in gamma-interferon-inducible lysosomal thiol reductase deficient mice
Hejun Liu, Scripps Res. Inst., The human IGHD3-22 encoded motif contributes to broad reactivity of anti-SARS-CoV-2 antibodies
Jennifer R. Habel, Univ. of Melbourne, at Peter Doherty Inst. for Infection and Immunity, Integrated immune networks in SARS-CoV-2 infected pregnant women reveal differential NK cell and unconventional T cell activation
Krista L. Newell, SUNY Upstate Med. Univ., Spike BATTLE: Simultaneous evaluation of antigen-specific B and T lymphocytes following natural SARS-CoV-2 infection and subsequent mRNA vaccination
Alba Grifoni, La Jolla Inst. for Immunology, SARS-CoV-2 vaccination induces T cell memory responses able to cross-recognize ongoing SARS-CoV-2 variants including omicron
Anastasia Minervina, St. Jude Children's Res. Hosp., Epitope-specific T cell response to SARS-CoV-2 infection and vaccination

Friday, May 6, 2022 2:00 PM – 4:00 PM Room C123–124

Immunoregulation—General

Chairs

Gudrun Debes, Thomas Jefferson Univ.
Robert Lochhead, Med. Col. of Wisconsin

Speakers

Neetu Gupta, Cleveland Clin., Myosin 18A is a novel checkpoint regulator in B cell differentiation and antibody-mediated immunity
Shannon E. McGettigan, Thomas Jefferson Univ., Secreted IgM modulates the pool of IL-10producing B Cells
Lance K. Blevins, Michigan State Univ., scRNA-Seq analysis of human CD5⁺ innate-like B cells identifies AHR expression as a marker of human CD9⁺ IL-10⁺ BRegulatory cells
Jason M. Zimmerer, Wexner Med. Ctr., Ohio State Univ., Alloprimed antibody-suppressor CD8⁺ T cells preferentially kill alloprimed germinal center B cells
Astrid E. Cardona, Univ. of Texas at San Antonio, Fibrinogen depletion ameliorates inflammation and vision loss in mouse models of diabetes
Gautham S. Ramakrishnan, Univ. of Oklahoma Hlth. Sci. Ctr., SHIP-2 inhibits human microglia-like cell function in a TREM2 independent manner
Dawit T.A. Mengistu, Univ. of Michigan, Tolerogenic markers on lung dendritic cells reversibly decrease following cigarette smoke exposure in mice
Meihong Deng, Wexner Med. Ctr., Ohio State Univ., Activation of TLR9 signaling in fibroblastic reticular cells enhances anti-tumor immunity in peritoneal tumor via suppressing peritoneal resident macrophage retention

Saturday, May 7, 2022 12:30 PM – 2:30 PM Room A105–106

Immunoregulation—Infection and Immunity

Chairs

Benjamin Hurrell, Univ. of Southern California
Omid Akbari, Keck Sch. of Med., Univ. of Southern California

Speakers

Karine Bouchard, Quebec Heart and Lung Inst., Université Laval, Macrophage inflammatory response increases in adult female exposed to neonate stress
Hector M. Nieves-Rosado, Univ. of Pittsburgh Sch. of Med., Tim-3 deletion on Treg increases virus-specific T cell response and reduces viral burden in chronic LCMV infection
Kunal Dhume, Univ. of Central Florida, Robust homotypic and heterosubytpic immunity against Influenza A Virus in mice lacking Th1/Tc1 transcriptional machinery
Manuja Gayashan Bandara Gunasena, Ohio State Univ., Immune determinants of cardiometabolic risk in pre-existing type-2 diabetes (T2D) severe COVID-19 patients
Monique M. Waldman, Univ. of Colorado Anschutz Med. Campus, Ena/VASP protein-mediated actin polymerization contributes to naive CD8⁺ T cell activation and expansion by promoting T cell-APC interactions in vivo
Mahmoud Abdelbary, Oregon Hlth. and Sci. Univ., Core fucosylation of N-linked glycans: a novel player in memory CD8⁺ T cell differentiation following acute viral infection
Thu A. Doan, Univ. of Colorado Anschutz Med. Campus, Archived antigen boosts CD8 T cell memory responses during an unrelated infection

Tuesday, May 10, 2022 8:00 AM – 10:00 AM Room B110–112

Immunoregulation—Innate Immune Responses

Chairs

Meera Nair, Univ. of California, Riverside
Emily Howard, Univ. of Southern California

Speakers

Mandy I. Cheng, Univ. of California, Los Angeles, UTX is an epigenetic regulator of natural killer cell development and anti-viral effector function.
Ajay Kumar, Univ. of Michigan, Glutamine addiction in NKT cells is regulated by AMPK-mTORC1 axis
Zarina Brune, Feinstein Inst. for Med. Res., Northwell Hlth., IRF5 regulation of CD4+ T cell metabolism controls CD40L expression
Erin E. West, NHLBI, NIH, Setting the pace: CD4 T cell-intrinsic Arginase 1 orchestrates Th1 induction and contraction
Jing Li, Stanford Univ. Sch. of Med., Human KIR⁺CD8⁺ T cells target pathogenic T cells in Celiac disease and are active in autoimmune diseases and COVID-19
Peyman Ghorbani, Univ. of Ottawa, Choline metabolism underpins macrophage IL-4 polarization in vitro and in vivo
Mandy M. Chan, Washington Univ. in St Louis Sch. of Med., Enhancing lysosomal lipid metabolism prevents the loss of Kupffer cells in non-alcoholic steatohepatitis and attenuates liver pathology

Friday, May 6, 2022 2:00 PM – 4:00 PM Room A105–106

Immunoregulation—Mechanism of Action

Chairs

Rana Herro, Cincinnati Children's Hosp. Med. Ctr.
Georges Helou, Univ. of Southern California

Speakers

Marina Ninkov, Univ. of Western Ontario, Canada, Chronic stress results in intrahepatic accumulation of a mononuclear myeloid-derived suppressor cell-like population
Temitayo Taiwo Bamgbose, Louisiana State Univ. Hlth. Sciences Ctr. at Shreveport, Lipin-1 restrains lipid synthesis to promote proresolving macrophage function and disease resolution
Carlos Alberto Mier Aguilar, Univ. of Alabama at Birmingham, Triggering receptor expressed on myeloid cells (Trem)-1 plays important roles in UVB induced immune suppression and cutaneous carcinogenesis
Pushpa Pandiyan, Case Western Reserve Univ., A new mechanism of Treg cell dysfunction during HIV infection and propensity to oral cancer in people living with HIV
Mohammad Nizam Mansoori, NIAID, NIH, Tregs suppress antigen-specific CD8⁺ T cells in vivo by depleting pMHC-I complexes from dendritic cells
Shaikh M. Atif, Univ. of Colorado Anschutz Med. Campus, Protective role of tissue-resident regulatory T cells in a murine model of beryllium-induced disease
Shokofeh Rahimpour, West Virginia Univ., A potential monocyte-regulatory T cell axis in neurorestoration following ischemic stroke

Sunday, May 8, 2022 8:00 AM – 10:00 AM Oregon Ballroom 201

Infection and Disease

Chairs

Marta Catalfamo, Georgetown Univ. Sch. of Med.
Bethany Mundy-Bosse, The Ohio State Univ. Col. of Med.

Speakers

Tanya Novak, Boston Children's Hosp. and Harvard Med. Sch., Genes associated with multiple organ dysfunction syndrome during severe pediatric influenza
Julie G. Burel, La Jolla Inst. for Immunology, Profiling the myeloid compartment of PBMC in active tuberculosis reveals substantial changes in CD14⁺ cells and upregulation of CD16 in pro-inflammatory dendritic cells
Jeffrey Alan Tomalka, Emory Univ. Sch. of Med., Inflammasomes and IL-1β: an innate immune axis in CD4+ T cells driving HIV infection and disease progression
Hadas Tamar Pahima, Hebrew Univ. of Jerusalem, COVID-19 patients are characterized by increased levels of immune cell membrane-bound and soluble CD48
Sarah C. Glover, Univ. of Mississippi Med. Ctr., Circulating extracellular vesicles from patients with severe COVID-19 upregulate Cathepsin B and activate STAT3 in normal human mesangial cells
Josh S. Mytych, Oklahoma Med. Res. Fndn., Bacillus anthracis peptidoglycan alters human M2-like macrophage phenotype and efferocytic function in the presence of human serum
Ismaila L. Manneh, London Sch. of Hygiene and Tropical Med., Targeted transcriptomic signature for monitoring anti-tuberculosis treatment response
Yashoda Madaiah Hosakote, Univ. of Texas Med. Br. at Galveston, SARS-CoV-2 induced oxidative stress promotes HMGB1 secretion to induce inflammation

Monday, May 9, 2022 10:15 AM – 12:15 PM Room A107–109

Innate Immune Response to Infection

Chairs

Fayyez Sutterwala, Cedars-Sinai Med. Center
Naeha Subramanian, Univ. of Washington

Speakers

Christopher Michael Horn, Univ. of Nebraska Med. Ctr., Glycolysis is critical for granulocytic myeloid-derived suppressor cell (G-MDSC) activity during Staphylococcus aureus biofilm infection
Maria J. Gonzalez Orozco, Univ. of Texas Med. Br. at Galveston, The E3-ligase TRIM7 acts as an antiviral factor by ubiquitinating the SARS-CoV-2 membrane protein to limit apoptosis and virus replication
Jacob S. Yount, Ohio State Univ., Interferon-induced transmembrane protein 3 (IFITM3) limits lethality of SARS-CoV-2 in mice
Smita Kulkarni, Texas Biomed. Res. Inst., Virus-induced long noncoding RNAs regulate SARS-CoV-2 pathogenesis
Ajay Suresh Akhade, Inst. for Systems Bio., Seattle, A non-canonical role of caspase-1 in regulating bacterial physiology and antimicrobial resistance
Jerod A. Skyberg, Univ. of Missouri-Columbia, Nucleotide receptors mediate protection against neonatal sepsis and meningitis caused by alpha-hemolysin expressing Escherichia coli K1
Juselyn D. Tupik, Virginia-Maryland Col. of Vet. Med., The Goldilocks Conundrum: The protective and adverse roles of immunoregulation by NOD-like receptors (NLRs) during brucellosis
Suman Gupta, Cedars Sinai Med. Ctr., Leptospira spp. are a potent activator of Type I IFN responses via the cGAS-STING pathway

Monday, May 9, 2022 12:30 PM – 2:30 PM Room B117–119

Innate Immune Sensing and Signaling

Chairs

Yuan He, Wayne State Univ. Sch. of Med.
Jian Zhang, Univ. of Iowa

Speakers

Yilei Ma, Univ. of Iowa, E-Syt1 ubiquitination by Nedd4 limits the caspase-11-mediated non-canonical inflammasome and endotoxemia
Yuan He, Wayne State Univ., Molecular basis for NEK7-mediated NLRP3 inflammasome activation
Chi Gidley Weindel, Texas A&M Univ., Col. of Med., Gasdermin D promotes hyperinflammation by triggering necroptosis in the presence of mitochondrial stress
Swathy Ollikara Vasudevan, UConn Hlth., A TLR4-independent critical role for CD14 in intracellular LPS sensing
Matthew R. Rice, Feinstein Inst. for Med. Res., STK25 functions as an IRF5 kinase to promote TLR7/8-mediated inflammation
Nayeon Son, Missouri State Univ., Identification of a novel protein interactions that elucidates the mechanism of hydatidiform molar pregnancies in women with NLRP2 and NLRP7 mutations
Jamie L. Shirley, Univ. of Colorado Anschutz Med. Campus, PD-L1 back signaling manipulates IL-6 signaling to coordinate innate immune responses

Sunday, May 8, 2022 12:30 PM – 2:30 PM Oregon Ballroom 203

Innate Immunity to Viral Infection

Chairs

Paul Thomas, St. Jude Children's Res. Hosp.
Shitao Li, Tulane Univ. Sch. of Med.

Speakers

Yakun Wu, Tulane Univ. Sch. of Med., Nuclear soluble cGAS senses DNA virus infection
Murugesan Rajaram, Ohio State Univ., Influenza A virus modulates ACE2 expression and SARS-CoV-2 infectivity in human cardiomyocytes
Jenny Resiliac, Research Institute at Nationwide Children's Hospital, Lipopolysaccharide pre-treatment prevents viral induced death by priming macrophages for a robust anti-viral immune response
Yi Yao, Henry Ford Hlth. Sys., Circulating monocytes co-expressing surface ACE2 and TMPRSS2 upon TLR4/7/8 activation are susceptible to SARS-CoV-2 infection
Jennifer R. Connors, Drexel Univ. Col. of Med., The impact of lipid nanoparticles (LNP) on anti-viral pathways and immune function in aged individuals
Marissa Lindman, Rutgers Univ., Astrocytic RIPK3 confers protection against deleterious neuroinflammation during Zika virus infection
Anshu Agrawal, Univ. of California Irvine, Innate immune mechanisms underlying sex differences in COVID-19

Monday, May 9, 2022 10:15 AM – 12:15 PM Oregon Ballroom 203

Innate Lymphocytes and Innate-Like T Cells in Cancer

Chairs

Robert Welner, Univ. of Alabama at Birmingham
Murad R. Mamedov, Univ. of California, San Francisco

Speakers

Valeriya Kuznetsova, Univ. of Alabama at Birmingham, Perturbed function of natural killer cells by inflammatory cytokines in acute (AML) and chronic (CML) myeloid leukemias
Sylvia M. Cruz, Univ. of California Davis Med. Ctr., Characterization of the tumor immune microenvironment in soft tissue sarcoma patients undergoing surgery
Monica Cho,Univ. of Wisconsin-Madison, CD155 axis modulation promotes natural killer cell-mediated graft-versus-tumor effects against osteosarcoma
Xia Liu, St. Louis Univ., The fate and function of NK cells in the suppressive tumor microenvironment
Narendiran Rajasekaran, Northern Arizona Univ., Assembly and localization of extracellular matrix protein fibronectin modulates Natural killer cell infiltration in tumor spheroids
Clemence Riffard, INSERM, LTi-like type 3 innate lymphoid cells are associated with the transient induction of tertiary lymphoid structures in inflamed pulmonary tissue
Murad R. Mamedov, Univ. of California, San Francisco, Genome-wide CRISPR screens reveal metabolic and transcriptional regulation of BTN3A and cancer susceptibility to VγVδ2 T cell targeting

Sunday, May 8, 2022 12:30 PM – 2:30 PM Room B110–112

Innate Signaling, Microbiome, and Metabolism in Autoimmunity

Chairs

Leah Kottyan, Cincinnati Children's Med. Ctr.
Betsy Barnes, The Feinstein Inst. for Med. Res., Northwell Hlth.

Speakers

Bharati Matta, Feinstein Inst. for Med. Res., IRF5 risk variants contribute to pre-symptomatic SLE by enhancing the levels of circulating NET antigens
Morgan Lee Terrell, Univ. of Florida, Treatment with TLR7/8 agonist compromises intestinal epithelium integrity in a lupus prone mouse model
Kevin MingJie Gao, Univ. of Massachusetts Med. Sch., Radioresistant cells in STING gain-of-function mice initiate lymphocyte dependent lung inflammation and IFNγ dependent mortality
David Nemazee, Scripps Res. Inst., Cleavage of DNA and RNA by PLD3 and PLD4 limits autoinflammatory triggering by multiple sensors, including endolysosomal TLRs and a STING dependent sensing pathway
Mitra Padideh Maz, Univ. of Michigan, Understanding innate immune cell-mediated inflammation in UV-induced skin injury in lupus-prone mice
William J. Turbitt, Univ. of Alabama at Birmingham, Neutrophil-specific Socs3 deficiency induces brain-targeted experimental autoimmune encephalomyelitis with enhanced cerebellar neutrophil activation
Shailesh K. Shahi, Univ. of Iowa, HLA Class II polymorphisms influence gut microbiota composition and modulate disease in transgenic mice model of multiple sclerosis
Mary A. Markiewicz, Univ. of Kansas Med. Ctr., The role of NKG2D signaling in NOD diabetes is affected by the microbiota

Tuesday, May 10, 2022 10:15 AM – 12:15 PM Room B110–112

Lymphocyte Homeostasis and Regulation

Chairs

Melanie Gubbels Bupp, Randolph-Macon Col.
Nu Zhang, Univ. of Texas Hlth. Sci. Ctr. at San Antonio

Speakers

Francesca Pala, NIAID, NIH, Profound abnormalities in thymic epithelial cells in Rag1 hypomorphic mice: implications for immune reconstitution after stem cell transplantation
Jason White, Osaka Univ., WPI Immunology Frontier Res. Ctr., Japan, T cell fate and central tolerance: using iTregs to elucidate the persistence of thymic development on a T cell's behavior
Byron B. Au-Yeung, Emory Univ. Sch. of Med., Strong tonic TCR signaling is associated with negative regulation of naive CD4+ T cells
Orchi Anannya, Cornell Univ., ITK tunes the Th17/Treg switch response by controlling calcium dependent signaling
Takesha R. Foster, Randolph-Macon Col., The Effect of malnutrition on T-cell circadian rhythms
Noor Bala, Col. of Vet. Med., Cornell Univ., Spatially restricted T-cell activation in inflamed tissues
Saranya Srinivasan, Univ. of Texas Hlth. Sci. Ctr. San Antonio, Age-dependent changes in the regulatory program of CD8⁺ Regulatory T cells (CD8⁺ Tregs)

Monday, May 9, 2022 10:15 AM – 12:15 PM Oregon Ballroom 201

Macrophages, Myeloid, and Dendritic Cells in Tumor Immunity and Immunotherapy

Chairs

Evan Lind, Oregon Hlth. and Sci. Univ.
Kenneth Murphy, Washington Univ. in St Louis Sch. of Medicine

Speakers

Briaunna M.N. Minor, Univ. of Rochester Med. Ctr., Estradiol effects on polymorphonuclear cell production and actions contribute to estrogen-mediated lymphangioleiomyomatosis (LAM) progression
Stacy K. Thomas, Perelman Sch. of Med., Univ. of Pennsylvania, Liver macrophage subsets differentially regulate metastasis in pancreatic cancer
Irene Saha, Cincinnati Children's Hosp. and Med. Ctr., The B cell adapter for PI3K (BCAP) promotes M2 macrophage phenotype and safeguards tumors from immune surveillance
David J. Friedman, Mayo Clin., Enhanced anti-tumor immunity in ST8Sia6 knockout mice
Jiaying Zheng, Mayo Clin. Grad. Sch. of BioMed. Sci., Hv1 proton channels control myeloid landscape and promote glioma progression
Patrick A. Flynn, Oregon Hlth. and Sci. Univ., Impact of constitutive FLT3 signaling on dendritic cell development and function in a genetically-engineered mouse model of Acute Myeloid Leukemia
Renee Wu, Washington Univ. in St Louis Sch. of Med., Mechanisms of CD40-dependent cDC1 licensing beyond co-stimulation

Saturday, May 7, 2022 8:00 AM – 10:00 AM Room B113–116

Mechanisms of Resistance to Therapy

Chairs

Jim Song, Texas A&M Univ.
William Lu, Univ. of Arkansas for Med. Sci.

Speakers

Arshmeet K. Chawla, Univ. of Connecticut Hlth. Ctr., β-adrenergic signaling modulates the development and activity of erythroid suppressor cells
Jianmei Wu Leavenworth, Univ. of Alabama at Birmingham, Remodeling of the tumor microenvironment via disrupting effector Treg activity augments response to checkpoint blockade
Avery Janese Salmon, Univ. of Texas MD Anderson Cancer Cntr. UTHealth Grad. Sch. of Biomed. Sci., BHLHE40: Required for regulation of effector T cells and remodeling of tumor microenvironment during immune checkpoint therapy
Adam L. Burrack, Univ. of Minnesota, TNF-α blockade improves immunotherapy efficacy by altering the tumor microenvironment and enhancing tumor-specific T cell function in pancreatic ductal adenocarcinoma
Nathan E. Reticker-Flynn, Stanford Univ. Sch. of Med., Lymph node colonization promotes distant tumor metastasis through the induction of tumor-specific immune tolerance
Evelyn M. Nguyen, Mem. Sloan Kettering Cancer Ctr., Targeting LSD1 rescues MHC class I antigen presentation and promotes immune checkpoint blockade response in small cell lung cancer
Vishnu Modur, Cincinnati Children’s Hosp. Med. Ctr., Tumors bearing defective transcription elongation are immune hot but resistant to immune checkpoint inhibitors

Monday, May 9, 2022 8:00 AM – 10:00 AM Oregon Ballroom 202

Mechanisms of Viral Sensing and Innate Immune Responses

Chairs

Steven Varga, Department of Microbiology and Immunology
Sachin Mulik, Univ. of Texas Hlth. Sci. Ctr. at Tyler

Speakers

Kody Waldstein, Univ. of Iowa, Alveolar macrophages act as an early viral sponge inducing long-lived functional enhancement
Lauren A. Chang, Icahn Sch. of Med. at Mount Sinai, Vaccination modulates pulmonary eosinophil subsets upon breakthrough influenza infection
Nina R. Derby, Seattle Children's Res. Inst., Liver biopsies reveal temporal changes in pathology and macrophage function following SIV infection of rhesus macaques
Chiefe Mo, California State Polytechnical Univ., Pomona, DEC-205-expressing dendritic cells inhibit T cell responses during West Nile Virus encephalitis in the central nervous system
Marcus P. Wong, Univ. of California, Berkeley, Investigating the role of inflammasome activation by dengue virus non-structural protein 1 during dengue infection
Daniel Miranda, Western Univ. of Hlth. Sci., A viral homologue of IPS-1 that reprograms innate immunity during viral replication
Weshely Kujur, Univ. of Texas Hlth. Sci. Ctr. at Tyler, Heterogeneity in NK memory stem cells after Zika virus infection using single cell approaches
Isaac J. Jensen, Columbia Univ. Med. Ctr., Novel mouse model of MCMV-induced adaptive NK cells

Friday, May 6, 2022 2:00 PM – 4:00 PM Oregon Ballroom 202

Memory T Cell Differentiation, Function, and Maintenance

Chairs

Nathan Schuldt, Univ. of Minnesota Med. Sch.
Yina Huang, Geisel Sch. of Med., Dartmouth Col.

Speakers

Terran D. Stenger, Univ. of Minnesota Med. Sch., Normal microbial experiences accelerate memory T cell compartment maturation in infants
Verena van der Heide, Icahn Sch. of Med. at Mount Sinai, Helpless CD8 T cell memory explained: prolonged antigen presentation drives a temporal rather than terminal defect
Taylor Heim, New York Univ. Langone Med. Ctr., CXCR6 is required for tissue resident memory T cell formation across diverse peripheral non-lymphoid tissues
Asmaa Mohamed, Geisel Sch. of Med., Dartmouth Col., Dendritic cells instruct differentiation of tissue resident memory T cells in the skin to promote durable tumor immunity
Henrique Borges da Silva, Mayo Clin., Cell-intrinsic expression of the hemichannel Pannexin-1 promotes effector and memory CD8⁺ T cells via distinct metabolic pathways
Daniel P. Caron, Columbia Univ. Med. Ctr., Human T cells in barrier sites exhibit site-specific characteristics and clonal compartmentalization
James R. Rose, Emory Univ. Sch. of Med., Epigenome accessibility changes before and after activation reveal distinct and progressive differentiation for human memory T cell subsets

Monday, May 9, 2022 8:00 AM – 10:00 AM Room A105–106

Microbiota and Epithelial Interactions

Chairs

Gretchen Diehl, Mem. Sloan Kettering Cancer Ctr.
Bei Liu, The Ohio State Univ.

Speakers

Soo M. Ngoi, Ohio State Univ., Migratory type 2 dendritic cells mediate mucosal Th17 response to gut commensal bacteria
Daniel Fernando Zegarra Ruiz, Mem. Sloan Kettering Cancer Ctr., Microbiota regulation of intestinal inflammation influences colorectal cancer
Emily M. Eshleman, Cincinnati Children's Hosp. Med. Ctr., Epithelial MHC class II directs microbiota-specific intestinal immune homeostasis
Elisabeth G. Foerster, Univ. of Toronto, Canada, Intestinal epithelial autophagy protects from cytokine-driven mortality and IFNγ-dependent cell death in acute small intestinal injury
Madeline J. Churchill, Oregon Hlth. and Sci. Univ., NAIP—NLRC4 inflammasome activation in tuft cells contributes to host defense against bacteria
Vini John, Washington Univ. Sch. of Med. in St.Louis, Goblet cells regulate expansion of colonic iNKT cells in CD1d-dependent manner
Simona Ceglia, Univ. of Massachusetts Med. School, Epithelial-derived oxysterol production tunes intestinal IgA secretion against commensals and enteric pathogen in tissue
Sarah E. Webster, Western Michigan Univ. Homer Stryker MD Sch. of Med., Influence of age, sex, and location on the diversity of the murine gut microbiome and/or expression of pro-inflammatory cytokines

Saturday, May 7, 2022 10:15 AM – 12:15 PM Room C123–124

Molecular and Cellular Control of Humoral Immunity

Chairs

Wei Luo, Indiana Univ. Sch. of Med.
Patricia Gearhart, NIA, NIH

Speakers

Carlos J. Ticas Rodas, NIA, NIH, Follicular B cells from old mice are hyper-responsive and produce non-specific antibodies
Christian Cervantes, Univ. of Texas Hlth. Sci. Ctr. San Antonio, PD-L1 plays a B cell-intrinsic role in suppressing the antibody response and anti-tumor immunity
Wei Luo, Indiana Univ. - Sch. of Med., Blimp1 controls GC B cell expansion and exit through regulating cell cycle progression and key transcription factors BCL6 and IRF4
Kim Good-Jacobson, Monash Univ., Targeting intrinsic regulators of antibody and B cell memory to control chronic viral infection
William Voss, Univ. of Texas at Austin, Differential serological immune imprinting following SARS-CoV-2 infection, vaccination, and breakthrough infection
Brian T. Gaudette, Perelman Sch. of Med., Univ. of Pennsylvania, The plasma cell proteome initiates early in B cell activation in advance of Blimp-1
J. Scott Hale, Univ. of Utah Sch. of Med., Tet2-mediated programing balances T follicular helper cell and T helper 1 cell differentiation
Nicole M. Arroyo, Univ. of Alabama at Birmingham, A temporal switch in T follicular helper cells controls the output of the GC response to influenza

Saturday, May 7, 2022 8:00 AM – 10:00 AM Oregon Ballroom 203

Molecular Mechanisms of Cytokine Function

Chairs

Laurie E. Harrington, Univ. of Alabama at Birmingham
Gail Bishop, Univ. of Iowa

Speakers

Nicholas N. Jarjour, Univ. of Minnesota Med. Sch., Common gamma chain-dependent cytokines drive antigen-independent proliferation of circulating and resident memory CD8⁺ T cells
Rosanne Spolski, NHLBI, NIH, Distinct super-enhancer elements differentially control Il2ra gene expression in a cell-type specific fashion
Milos Vujanac, Univ. of Miami Miller Sch. of Med., Regulation of IL-2- and IL-6-dependent signaling in human Tregs by CISH and SOCS3
Emma Hornick, Univ. of Iowa, TRAF3 enhances type I interferon (IFN I) receptor signaling in T cells through modulation of the phosphatase PTPN22
Harold A. Silverman, Feinstein Institutes for Med. Research, Northwell Hlth., Transient receptor potential ankyrin 1 (TRPA1) mediates IL-1β-induced thermoregulation
Sonya Wolf, Michigan Med. at Univ. of Michigan, Interferon kappa (IFNk) in keratinocytes is critical for normal wound repair and is decreased in diabetic wounds
Emily A. Dennis, Univ. of Virginia, Loss of ten-eleven translocation 2 (TET2) reduces CCR6 expression and increases B1 B cell number in the peritoneal cavity
Audrey Kwun, Cleveland Clin. Fndn., Sustained NPSLE development in the absence of systemic lupus-like disease in TLR7-deficient B6.Nba2

Sunday, May 8, 2022 8:00 AM – 10:00 AM Room B117–119

Molecular Mechanisms of Inflammation

Chairs

Kristin Patrick, Texas A&M Univ., Col. of Med.
Brooke Napier, Portland State Univ.

Speakers

Haley M. Scott, Texas A&M Hlth. Sci. Ctr., Serine Arginine Splicing Factor 7 (SRSF7) is a critical regulator of innate immune activation in macrophages
Stephanie R. Shames, Kansas State Univ., Effector-mediated subversion of proteasome activator (PA)28αβ enhances lysosomal pathogen targeting within cytokine-activated macrophages
James Robert Fisher, Univ. of Texas Med. Br. at Galveston, Mincle and TNF signaling crosstalk enhances type 1 and innate immune responses to Orientia tsutsugamushi
Antonio J. Pagán, Univ. of Cambridge, mTOR-associated mitochondrial energy metabolism limits mycobacterium ESX-1-induced cytotoxicity
Amy Lorraine Seufert, Portland State Univ., Palmitic acid reprograms inflammatory responses to microbial ligands in macrophages, and mediates innate immune memory in vivo
Haleigh Gilliland, Michigan State Univ., Defining complex mechanistic interactions and responses by macrophages during Mycobacterium abscessus infection
Cheyenne Palm, Towson Univ., NADase activity found in bacterial TIR proteins may aid in innate immune evasion
Michal Caspi Tal, Stanford Univ. Sch. of Med., P66 is a bacterial "don't eat me signal" that mimics mammalian CD47 and facilitates immune evasion by Borrelia burgdorferi

Tuesday, May 10, 2022 10:15 AM – 12:15 PM Room A105–106

Molecular Mechanisms of T Cell Signaling

Chairs

Fabienne Gally, Natl. Jewish Hlth., Colorado
Kaushik Choudhuri, Univ. of Michigan Med. Sch.

Speakers

Fenglei Li, Univ. of Michigan Med. Sch., TCR-enriched microvesicles provide antigen-specific help for class-switched antibody production
Melissa Erin Cook, Washington Univ. in St. Louis, Sch. of Med., The ZFP36 family of RNA-binding proteins regulate homeostatic and autoreactive T cell responses
Jasmine Tuazon, Ohio State Univ. Col. of Med., The Ikaros zinc finger transcription factor Eos as a candidate regulator of T_H2 differentiation and function
Nicole M. Carter, Johns Hopkins Univ. Sch. of Med., QRICH1 is a CARD11 interactor that negatively regulates T cell activation
Jacob W. Thompson, Univ. of Utah, Cell-specific roles for miR-155 during neuroinflammation
Wen Lu, Univ. of California, San Francisco, The phosphatidylinositol-transfer protein Nir3 modulates T cell development and function
Shuvam Mohan Chaudhuri, Feinberg Sch. of Med., Northwestern Univ., Mediator complex maintains peripheral T cell tolerance through enforcement of the quiescence module
Katja Aviszus, Natl. Jewish Hlth., Colorado, Absence of the fatty acid binding protein5 (FABP5) inhibits the establishment of resident memory T cells after a secondary Listeria monocytogenes infection

Monday, May 9, 2022 3:45 PM – 5:45 PM Room C123–124

Molecular Regulation of Innate and Cytotoxic Lymphocyte Responses

Chair

Jie Sun, Univ. of Virginia

Speakers

Etienne Humblin, Icahn Sch. of Med. at Mount Sinai, CD28 signaling strength regulates the cell fate of TCF-1+ PD-1+ CD8 T cells
Michael Battaglia, Univ. at Buffalo Sch. of Med. and BioMed. Sci., Ets1 regulates production of dendritic epidermal T cells (DETC) and cooperates with IL17Ra signaling to regulate immune responses to Staphylococcal skin infection
Thomas Riffelmacher, La Jolla Inst. for Immunology, Metabolic fuel choices control MAIT cell functions at homeostasis and after infection
Timofey Karginov, UConn Hlth., Optimal CD8⁺ T cell effector function requires costimulation-induced RNA-binding proteins that reprogram the transcript isoform landscape
Eshana Mukhopadhyay, Cincinnati Children's Hosp. Med. Ctr., A role for a DEAD box RNA helicase in natural killer cells
Mark Elliott Williams, Emory Univ. Sch. of Med., Lineage analysis defines subpopulations of human lung tissue-resident memory CD8+ T cells
Reed M. Hawkins, Oregon Hlth. and Sci. Univ., Androgen receptor regulation of CD8 T cell immune responses
Connie Krawczyk, Van Andel Inst., The sexually dimorphic histone demethylase promotes optimal T cell responses during infection

Saturday, May 7, 2022 3:45 PM – 5:45 PM Room A105–106

Molecular, Metabolic, and Epigenetic Regulation of Innate Immunity and Inflammation

Chairs

Connie Krawczyk, Van Andel Inst.
Sarah Ewald, Univ. of Virginia

Speakers

Chao Yang, Hosp. for Special Surgery, Costimulation of TLR8 responses by CXCL4 in human monocytes mediated by TBK1-IRF5 signaling and epigenomic remodeling
Matthew D. Woolard, Louisiana State Univ. Hlth. Sciences Ctr. at Shreveport, Lipin-1 integrates lipid metabolism with macrophage function to promote inflammation resolution
David Orlando Diaz-Jimenez, NIEHS, NIH, Glucocorticoids suppress NLRP3 Inflammasome activation through transcriptional metabolic reprogramming of IRG-1/ACOD1 in macrophages
Raza Ali Naqvi, Univ. of Illinois at Chicago, Modulation of myeloid cell functions by long noncoding RNAs RN7SK and HCG11
Alicer Keendalyn Andrew, Univ. of Georgia, Relationships between inflammation, coagulation, and oxidative stress in malaria-induced pregnancy compromise
Abhimanyu Abhimanyu, Baylor Col. of Med., Targeting TCA cycle metabolites by small molecule inhibitors ameliorate LPS induced immune tolerance in Macrophages through epigenetic mechanisms
Katherine E. Lothstein, Rutgers Univ. New Jersey Med. Sch., Helminth TGF-β mimic, TGM, increases leukocyte migration and activation while also enhancing cutaneous wound healing and tissue regeneration

Monday, May 9, 2022 3:45 PM – 5:45 PM Room B117–119

Mucosal Immune Regulatory Mechanisms

Chairs

Craig L. Maynard, Univ. of Alabama at Birmingham
Meghan A. Koch, Fred Hutchinson Cancer Res. Ctr.

Speakers

Susan Kovats, Oklahoma Med. Res. Fndn., Androgens protect ILC2s from interferon-mediated functional suppression during influenza virus infection
Kaylyn Bauer, Univ. of Utah, Rab27A-dependent transfer of CD11c+ cell exosomes regulate gut immunity
Marina Chulkina, Pennsylvania State Univ. Col. of Med., MyD88-mediated signaling in myo-/fibroblasts is required for control of macrophage maturation under mucosal tolerance in the gut
Emma Erlich, Washington Univ. in St Louis Sch. of Med., B cells drive tertiary lymphoid organ formation in ileal inflammation
Andrea Reboldi, Univ. of Massachusetts Med. Sch., IgA B cell receptor signaling protects from FasL counterselection during germinal center reaction in Peyer’s patches and shapes humoral mucosal response.
Jason L. Kubinak, Univ. of South Carolina Sch. of Med., Defective humoral immunity disrupts bile acid homeostasis which promotes inflammatory disease of the small bowel
Elisa Cruz Morales, Perelman Sch. of Med., Univ. of Pennsylvania, Analysis of the mechanisms that maintain intestinal regulatory T cells
Warakorn Kulalert, NIH, Functional tuning of commensal-specific lymphocytes by nociceptive sensory neurons

Sunday, May 8, 2022 8:00 AM – 8:00 AM Room A105–106

Mucosal Innate Immune Cells

Chairs

Andea Reboldi, Univ. of Massachusetts Med. Sch.
Paige Porrett, Univ. of Alabama at Birmingham Sch. of Med.

Speakers

Wan-Jung Wu, Mem. Sloan Kettering Cancer Ctr., Select mucosa-associated intestinal commensal bacteria promote gut barrier repair by inducing IL-1b production
Michela Frascoli, Univ. of Massachusetts Med. Sch., Crosstalk between skin homing innate T cells and epithelial cells via cholesterol byproduct messengers is required for tissue immunity
Jia Nie, NCI, NIH, The transcription factor LRF promotes Integrin β7 expression by and gut homing of CD8αα intraepithelial lymphocyte precursors
Xuqiu Lei, Univ. of Massachusetts Chan Med. Sch., Epithelial HNF4A shapes the intraepithelial lymphocyte compartment via direct regulation of immune signaling molecules
Angeline Chen, La Jolla Inst. for Immunology, Small intestine epithelial CD4 cytotoxic T lymphocytes provide innate-like protection against enteric pathogens without risk of immunopathology
Paige Porrett, Univ. of Alabama at Birmingham Sch. of Med., Aberrant survival of uterine natural killer subsets in uterus transplant recipients
Thanh Thanh Trinh Dinh, The Ohio State Univ. Col. of Med., ILC3 expansion in acute myeloid leukemia

Monday, May 9, 2022 12:30 PM – 2:30 PM Room B110–112

Neonatal Mucosal Immunity

Chairs

Kathryn A. Knoop, Mayo Clin.
Michael A. Silverman, Children's Hosp. of Philadelphia

Speakers

Michael A. Silverman, Children's Hosp. of Philadelphia, Arresting microbiome development limits immune system maturation and resistance to infection
Katherine Z. Sanidad, Weill Cornell Med., Gut microbiome regulates serotonin production in the neonatal intestine to promote immune tolerance in early life
Mohammed Amir, Weill Cornell Med., Gut microbiota-reactive IgG regulates gut microbiota development and immunity against enteric pathogens in early life
Kara G. Greenfield, Mayo Clin., Maternally derived epidermal growth factor mediates protection in neonates from opportunistic intestinal pathogens.
Ellen Merrick Schill, Washington Univ. in St Louis Sch. of Med., Neonatal antibiotic exposure alters intestinal macrophage frequency and polarization
Elizabeth Managlia, Ann & Robert H. Lurie Children's Hosp. of Chicago, CD206⁺MHCII^- macrophages present in the neonatal but not adult intestine do not derive from LysM monocytes and are decreased in experimental Necrotizing Enterocolitis
Julia A. Brown, Weill Cornell Med. Col., The preterm infant microbiome impairs lung immune responses to respiratory syncytial virus infection

Sunday, May 8, 2022 12:30 PM – 2:30 PM Room B117–119

Neuronal and Central Nervous System Immunity

Chair

Aaron Johnson, Mayo Clin. Rochester

Speakers

Arya Biragyn, NIA, NIH, A surprising pathogenic role of B cells in mice with Alzheimer's disease
Pooja Jain, Drexel Univ. Col. of Med., Nutraceutical Apigenin regulates DC function in a RelB-dependent manner during neuroinflammation
Zhangying Chen, Feinberg Sch. of Med., Northwestern Univ., T-cell infiltrates and microglia adopt long-term gene signature changes leading to age-specific responses to traumatic brain injury in mice
Ling Cao, Univ. of New England, Responses of injured nerve in CD137L knockout mice following sciatic nerve crush-induced neuropathic pain
Murugaiyan Gopal, Brigham and Women's Hosp. and Harvard Med. Sch., MicroRNA control of inflammatory and regulatory T cells in CNS autoimmunity
Ling Cao, Univ. of New England, Electromyographic characterization and bioinformatic pathway analysis of spinal cord inflammation in a Tat induced HIV-associated sensory neuropathy model
Yan Wang, Thomas Jefferson Univ., Single-cell RNA sequence (scRNAseq) analysis of T regulatory cells in relapsing remitting multiple sclerosis (RRMS)

Tuesday, May 10, 2022 8:00 AM – 10:00 AM Room B113–116

Non-Immune Therapies in Cancer

Chair

Michael Gough, Earle A Chiles, Providence Cancer Inst.

Speakers

Guilan Shi, Univ. of South Florida, Gene therapy increases MHC class-I and T cell Infiltration to promote anti-tumor immune response in 4T1 breast cancer model
Michael J. Gough, Providence Portland Med. Ctr., Fluorescence tagging to monitor CD8 T cell recirculation from the tumor to the tumor-draining lymph node: the impact of focal radiation therapy on recirculation
Hua Laura Liang, Univ. of Chicago, Induction of inflammatory macrophages in solid tumors by all-trans retinoic acid augments radiation efficacy
Michael Walsh, Harvard Med. School, IFNγ from IL-12 virotherapy stably controls tumors independent of T cell cytotoxicity and IFNγ sensing by tumor cells
Hongji Zhang, Wexner Med. Ctr., Ohio State Univ., Preoperative exercise therapy attenuates liver metastases following surgical stress by inducing Kupffer cells-mediated anti-tumor immunity
Khan Mohammad Imran, Translational Biology, Med. and Health, Virginia Tech, IFNγ mediated PD-L1 expression mitigate the immunomodulatory effect of irreversible electroporation on pancreatic cancer

Saturday, May 7, 2022 3:45 PM – 5:45 PM Oregon Ballroom 201

Overcoming Current Roadblocks in CAR T Cell Therapy

Chair

Anna Halling Folkmar Andersen, New York Univ. Langone Med. Center

Speakers

Monika Kizerwetter, Johns Hopkins Univ., Anti-CD123 chimeric antigen receptor natural killer cell therapy to treat acute myeloid leukemia
Nicholas R. J. Gascoigne, Natl. Univ. of Singapore, Utilizing distinct CAR and TCR signaling to generate enhanced cellular immunotherapy
Daniel S. Wilkinson, Duke Univ. Med. Ctr., D2C7 CAR: A novel CAR T cell that simultaneously targets wildtype EGFR and its mutant isoform EGFRvIII for treatment of glioma
Jillian Baker, Univ. of Maryland Sch. of Med., Engineering anti-CD229 CAR T cell selectivity for multiple myeloma
Xander Gordon Ray Bradeen, Univ. of Colorado Anschutz Med. Campus, Identifying novel epigenetic modifiers that sensitize T cell malignancies to CD8⁺ T cell mediated cytotoxicity by high throughput drug screen
Royce Ma, Baylor Col. of Med., T cells resist CD5 CAR mediated fratricide by continuously degrading CD5 protein
Caitlin C. Zebley, St. Jude Children's Res. Hosp., CD19-CAR T cells develop exhaustion epigenetic programs during a clinical response
Nayan Jain, Mem. Sloan Kettering Cancer Ctr., SUV39H1 disruption imparts functional persistence to CD28-costimulated human CAR T cells

Saturday, May 7, 2022 10:15 AM – 12:15 PM Oregon Ballroom 202

Pathogenesis of SARS-CoV-2 Infection

Chairs

Amelia Pinto, Saint Louis Univ. Sch. of Med.
Majid Kazemian, Purdue Univ.

Speakers

Elizabeth Geerling, St. Louis Univ., Sch. of Med., Metabolic syndrome enhances viral disease severity and reduces vaccine efficacy in mice
Jian Zheng, Univ. of Iowa, Eicosanoid signaling as a therapeutic target in middle-aged mice with severe COVID-19
Stephen T. Yeung, Weill Cornell Grad. Sch. of Med. Sci., Galectin-9 protects humanized-ACE2 immunocompetent mice from SARS-CoV-2 Infection
Bingyu Yan, Purdue Univ., SARS-CoV-2 drives JAK1/2-dependent local complement hyperactivation
Ksenia Rybkina, Columbia Univ. Med. Ctr., Children with Multi-System Inflammatory Syndrome (MIS-C) develop functionally competent T cell memory against SARS-CoV-2 following recovery
Zehra Rahman, Univ. at Buffalo Sch. of Med. and BioMed. Sci., Exploration of shared antibody motifs in Kawasaki Disease (KD) and COVID-19 related Multisystem Inflammatory Syndrome of Childhood (MIS-C)
Brandi L. Clark, St. Jude Children's Res. Hosp., Identifying distinct T cell subsets in the context of pediatric ARDS
Yu Gao, Karolinska Inst., SARS-CoV-2 mRNA vaccination induces polyfunctional T cell responses in healthy and immunocompromised individuals

Sunday, May 8, 2022 10:15 AM – 12:15 PM Oregon Ballroom 201

Primary Immune Deficiency and Immune Dysregulation

Chairs

Emily M. Mace, Columbia Univ.
Elissa Deenick, Garvan Inst. of Med. Res.

Speakers

Ruth J. Napier, Oregon Hlth. and Sci. Univ., T cell intrinsic role for NOD2 in Blau Syndrome
Marita Bosticardo, NIAID, NIH, Characterization of thymic epithelial cell and thymocyte function and development in patients with thymic defects using scRNAseq profiling
Zinan Zhang, Harvard Med. Sch., Bi-allelic TTC21A mutations in common variable immunodeficiency patients
Sukalp Muzumdar, Cold Spring Harbor Lab., A granular view of X-linked chronic granulomatous disease exploiting single-cell transcriptomics
Julia Bier, Garvan Inst. of Med. Res., Australia, T cell extrinsic mechanics explaining the T cell hyperactivation seen in Activated PI3K δ Syndrome
Nicolai S. van Oers, Univ. of Texas Southwestern Med. Ctr., 22q11.2 deletion syndrome causes a thymus hypoplasia corrected by mesenchymal cell replacement
Olivia Bailey, Univ. of Colorado Anschutz Med. Campus, Dissecting the effect of a novel hypomorphic IL2RB mutation on immune dysregulation
Jose S. Campos Duran, Perelman Sch. of Med., Univ. of Pennsylvania, Dysregulation of CD8⁺ T cell function in the setting of altered cytokine signaling due to inborn errors of immunity

Friday, May 6, 2022 2:00 PM – 4:00 PM Room B110–112

Pulmonary, Vasculature, and Skin Immunity

Chairs

Estelle Cormet-Boyaka, Col. of Vet. Med., The Ohio State Univ.
Erika Darrah, John Hopkins Med. Inst.

Speakers

Young me Yoon, Univ. of Chicago, Interstitial lung disease patients exhibit augmented germinal center responses in lung lymph nodes and increased serum reactivities to novel autoantigens
Anshu Agrawal, Univ. of California Irvine, Differential response of dendritic cells and macrophages to signals from airway epithelial cells in humans: changes with age
Fatema Alrashed, Dasman Diabetes Inst., Candida albicans Induces Foaming and Inflammation in Macrophages through FABP4: Its Implication for Atherosclerosis
David Cheng Yang, Univ. of California, Davis, Tobacco smoke activated fibrogenic MARCKS/AXL complex promotes macrophage reprogramming and pulmonary fibrosis
Alexandre Cammarata-Mouchtouris, Emory Univ. Sch. of Med., Pathological metabolic adaptation of neutrophils recruited to cystic fibrosis airway microenvironment can not be reversed by modulator therapy
Shuto Kanameishi, Kyoto Univ., Lymphotoxin &β receptor signaling mediates the formation of high endothelial venule-like vessels in atopic dermatitis-like skin lesions in mice
Hyeung Ju Park, Mem. Sloan Kettering Cancer Ctr., Epithelial mesenchymal transition of epithelial cells induced by TGF-β signaling in lymphedema
Eleni Tiniakou, Johns Hopkins Univ., Discovery of antigen specific CD4+ T cells in anti-3-hydroxy-3-methylglutaryl coenzyme A reductase (HMGCR) immune mediated necrotizing myopathy (IMNM)

Saturday, May 7, 2022 8:00 AM – 10:00 AM Room B110–112

Regulation of B and T Cells in Autoimmune Diseases

Chairs

Hubert M.Tse, Univ. of Alabama at Birmingham
Virginia Shapiro, Mayo Clin.

Speakers

Tracoyia A.Roach, Univ. of Florida, Lupus susceptibility gene pbx1 regulates stat3 in T cells via jak2/stat3 signaling pathway
Hu Zeng, Mayo Clin. Col. of Med. and Sci., mTORC2 contributes to murine lupus associated immunopathology
Anne B. Satterthwaite, Univ. of Texas Southwestern Med. Ctr., B cell subsets contributing to the autoreactive plasma cell pool in Lyn-/- mice
Samuel I. Blum, Univ. of Alabama at Birmingham, NADPH oxidase-derived superoxide promote autoreactive T cell infiltration into islets of prediabetic NOD mice
Stephanie J. Grebinoski, Univ. of Pittsburgh Sch. of Med., Intra-islet CD8⁺ T cells are restrained by an exhaustion program that can be partially reversed in the absence of LAG3
Alexander W. Boyden, Univ. of Iowa Carver Col. of Med., B cell-mediated antigen presentation is required to induce functional pathogenicity of CD4 T cells in a proteolipid protein mouse model of multiple sclerosis
Sydney B. Crotts, Mayo Clin., Regulation of inflammatory bowel disorder by ST8Sia6
Yuying Liu, McGovern Med. School, Univ. of Texas Hlth. Sci. Ctr. at Houston, Phenotype of CD39/CD73 expressed on T cells in a mouse model of IPEX syndrome

Sunday, May 8, 2022 8:00 AM – 10:00 AM Room C123–124

T Cell Effector Generation and Function

Chairs

Takeshi Egawa, Washington Univ. Sch. of Med.
Sarah Hamilton, Univ. of Minnesota

Speakers

Anna Halling Folkmar Andersen, Aarhus Univ., Single-cell TCR and mRNA sequencing of antigen-specific T cells reveal spatial trajectories from single time points with HLA and VDJ bias
Ao Guo, St. Jude Children's Res. Hosp., The SWI/SNF canonical BAF complex and c-Myc cooperate to promote early fate decisions in CD8⁺ T cells
Jessica A. Gaevert, St. Jude Children's Res. Hosp., Characterization of the cross-reactive T cell repertoire in the context of heterosubtypic influenza A virus infection
Erin D. Lucas, Univ. of Minnesota, Expansion and maintenance of long lived effector CD8 T cells is modulated by inflammation
Yu Xia, Washington Univ. in St Louis Sch. of Med., BCL6-dependent TCF-1+ progenitor cells maintain effector and helper CD4 T cell responses to persistent antigen
Mirela Kuka, Università Vita Salute San Raffaele, A fluorescent reporter model to study the role of T_DC during infection and cancer

Saturday, May 7, 2022 8:00 AM – 10:00 AM Room A105–106

Technological Innovations in Immunology I

Chairs

Yuri Sykulev, Thomas Jefferson Univ.
Amanda M. Burkhardt, Univ. Southern California

Speakers

Yunhao Zhai, Wyss Inst. for Biologically Inspired Engin. at Harvard Univ., A human ectopic-lymphoid-follicle-on-a-chip for testing vaccines and adjuvants
Armando Javier Arroyo-Mejías, NIAID, NIH, 3D-IBEX: achieving multiplex 3-dimensional imaging for deep phenotyping of cells in tissues
Yuri Sykulev, Thomas Jefferson Univ., CD16 and NKG2D co-clustering facilitates quality of primary NK cell responses
Tim Le Fevre, STEMCELL Technologies, Inc., Generation of large numbers of functional NK cells without feeders or serum
Hing C. Wong, HCW Biologics, A feeder cell-free activation and expansion strategy to generate memory-like NK cells sufficient for off-the-shelf multi-dose adoptive cell therapy
Timothy C. Borbet, New York Univ. Sch. of Med., Leveraging mouse genetics to generate heavy-chain only antibodies for therapeutic application
Michael J.T. Stubbington, 10x Genomics, Discovery of potently-neutralizing antibodies against SARS-CoV-2 using Barcode Enabled Antigen Mapping (BEAM)

Sunday, May 8, 2022 10:15 AM – 12:15 PM Oregon Ballroom 204

Technological Innovations in Immunology II

Chairs

Amanda M. Burkhardt, Univ. of Southern California
Yuri Sykulev, Thomas Jefferson Univ.

Speakers

Joseph Cornelius Lownik, Cedars Sinai Med. Ctr., Expanding the use of clustering and dimensionality reduction in high parameter flow cytometry data through machine learning for novel samples
Vaishnavi Kaipilyawar, Rutgers New Jersey Med. Sch., Derivation of a parsimonious Tuberculosis gene signature using the digital NanoString nCounter platform
Lanaiah M. Ieremia, Texas Tech Univ. Hlth. Sci. Ctr. El Paso, Host-targeted self-attenuated influenza virus as a potential therapeutic influenza vaccine
Shijie Cao, Univ. of Chicago, Lymph node-targeted long-acting butyrate micelles induce regulatory immune modulation
Sophia Liu, MIT, Spatially mapping T cell receptors and transcriptomes
Irene E. Whitney, Honeycomb Biotechnologies, HIVE Single-cell TCR sequencing: assay principle and applications
Sheila Burns, Applied Cells, Inc., A multi-physics approach for high recovery and purity isolation of plasma cells in whole blood

Sunday, May 8, 2022 12:30 PM – 2:30 PM Room B113–116

The Impact of the Commensal Microbiome on Cancer Progression and Therapy Response

Chairs

Melanie R. Rutkowski, Univ. of Virginia
Irving Allen, Col. of Vet. Med.. Virginia Tech

Speakers

Kaiting Yang, Univ. of Chicago, Suppression of local IFN-I by commensal microbiota-derived butyrate impairs antitumor effects of ionizing radiation
Qingsheng Li, Univ. of Louisville, Dietary low-fiber promotes resistance to immune checkpoint inhibitor immunotherapy in the LSL-Kras^G12D Lung Cancer Model
Romina E. Araya, NCI, NIH, Neutrophil dynamics in the tumor microenvironment determines therapy efficacy and is regulated by microbiota
Liangliang Wang, Univ. of Chicago, Lactobacillus rhamnosus GG re-shapes gut microbiota and triggers STING-type I IFN-dependent antitumor immunity
Mitchell Thomas McGinty, Univ. of Virginia, Absence of Toll-like receptor 5 confers survival in mice bearing ovarian tumors treated with anti-PD-L1
Qingsheng Li, Univ. of Louisville, Resistance to Anti-PD-1 Therapy is mediated via the Microbiota-Th17-Prostoglandin E2 Axis in the LSLKras^G12D Lung Cancer Model
Khiem C. Lam, NCI, NIH, Tumor-intrinsic factors dictate beneficial effect of microbiota-based therapies

Saturday, May 7, 2022 12:30 PM – 2:30 PM Oregon Ballroom 202

The Ins and Outs of Airway Inflammation

Chairs

Rebecca Martin, Virginia Commonwealth Univ.
De'Broski Herbert, Univ. of Pennsylvania Sch. of Vet. Med.

Speakers

Jorge F. Ortiz-Carpena, Perelman Sch. of Med., Univ. of Pennsylvania, Sensory neurons shape allergic Type 2 inflammation in the sinonasal tract
Anukul T. Shenoy, Boston Univ., Mouse model of late-onset neutrophilic asthma reveals an epithelium-lymphocyte-neutrophil communication circuit underlying destructive airway neutrophilia
Jihyun Yu, Korea Advanced Inst. of Sci. and Technol., GPR43 signaling in lung eosinophils suppresses neutrophilic airway inflammation in asthma
Rama Krishna Gurram, NHLBI, NIH, TSLP and IL-33 distinctively modulate the allergic response by differentially modulating Th2 cells and ILC2sM
Anuj Tharakan, Virginia Commonwealth Univ. Sch. of Med., Blockade of dendritic cell glutaminolysis induces allergic asthma desensitization via suppression of Tfh13 polarization
Abigail Pajulas, Indiana Univ. Sch. of Med., T_H9-derived IL-9 promotes CCR2-dependent mast cell accumulation in the allergic lung
Ceire Hay, Perelman Sch. of Med., Univ. of Pennsylvania, Interrogating mechanisms of CD8 T cell dysfunction in obese asthma
Lars P. Lunding, Res. Ctr. Borstel, The NLRP3 Inflammasome Inhibitor OLT1177® Ameliorates Experimental Allergic Asthma in Mice

Sunday, May 8, 2022 3:45 PM – 5:45 PM Oregon Ballroom 202

Therapies for Rheumatic Diseases and Beyond

Chairs

Randy S. Longman, Weill Cornell Med.
Laurence M. Morel, Univ. of Florida Col. of Med.

Speakers

Rinkesh Kumar Gupta, La Jolla Inst. for Immunology, Therapeutic targeting of tumor necrosis factor like weak inducer of apoptosis (TWEAK) in psoriasis
Yogesh Scindia, Univ. of Florida, Renal tubular cell ferroptosis: a new player in pathogenesis of lupus nephritis
Ahmed Samir Elshikha, Univ. of Florida, The gut microbiota transfers the therapeutic effect of inhibiting glucose metabolism in lupus-prone mice
Svetlana Ferreira Lima, Weill Cornell Med., Defining the role for the gut microbiome in the clinical efficacy of sulfasalazine therapy for IBD associated spondyloarthritis
Longhuan Ma, Univ. of Florida, A combination of genetic factors and dietary tryptophan shapes gut microbial dysbiosis in a lupus-prone mouse model
Laura Santambrogio, Weill Cornell Med., Characterization of a novel anti-inflammatory biogenic amine
Hu Zeng, Mayo Clin. Rochester, The immune dysregulations in inflammatory arthritis immune related adverse events
Justin Choe, Mayo Clin. Grad. Sch. of BioMed. Sci., ST8Sia6 expression in beta cells mitigates onset of autoimmune diabetes in the murine NOD model

Saturday, May 7, 2022 8:00 AM – 10:00 AM Room C123–124

They Come and They Go: A Leukocyte Migration Extravaganza

Chairs

Judy Cannon, Univ. of New Mexico
Michael Gerner, Univ. of Washington

Speakers

Zev Joshua Greenberg, Washington Univ. in St Louis Sch. of Med., The tetraspanin CD53 as a novel regulator for B cell trafficking
Tonya Aaron, Albert Einstein Col. of Med., Inflammation depletes humoral immunity by limiting plasma cell access to the bone marrow survival niche
Paulus Mrass, Univ. of New Mexico, CXCR4 promotes the stop signal and degranulation of cytotoxic T cells infiltrating influenza-infected lungs
Farhat Parween, NIAID, NIH, CCR2 identifies two subtypes of pathogenic human type 17 Th cells and has a non-redundant role in their transendothelial migration
Wenji Piao, Univ. of Maryland Sch. of Med., PD-1 licenses activated Treg for lymphatic migration
Michael Y. Gerner, Univ. of Washington, Dendritic cells regulate innate cell trafficking into lymph nodes during inflammationM
Lai Wen, La Jolla Inst. for Immunology, A new β₂ integrin activation reporter mouse reveals localized intra- and extra-vascular neutrophil integrin activation in vivo
Hemant Joshi, Washington Univ. in St. Louis Sch. of Med., Mechanical stress modulates NLRP3 pathway in macrophages

Saturday, May 7, 2022 10:15 AM – 12:15 PM Oregon Ballroom 204

Tissue Immunity at Barrier Sites

Chairs

Gianna E. Hammer, Duke Univ.
Shipra Vaishnava, Brown Univ.

Speakers

Michael Stolley, Univ. of Minnesota, Leveraging resident memory t cells to fortify oral immunity
Gabriel Antonio Ascui-Gac, La Jolla Inst. for Immunology, RAMP3 unexplored relevance for innate-T cell immunity
Colette Matysiak, Harvard Med. Sch., Intranasal, not parenteral, vaccination induces the formation of tissue-resident memory CD8 T cells in nasal mucosa that rapidly clear influenza virus infection
Tanvi Arkatkar, Univ. of Washington, Bystander CD8 T cell memory responses partially protect mice against lethal vaginal HSV-2 challenge
Vineet Joag, Univ. of Minnesota, Sensing and alarm function of vaccine-elicited SIV-gag specific CD8 T_RM in the reproductive mucosa of rhesus macaques
Elaine Kouame, Univ. of Chicago, The miseducation of T cells in autoimmunity
Ziqi Chen, Harvard Med. Sch., Parenteral vaccination strategies target protective immunity to the small and large intestine mucosa
Gowri Kalugotla, Washington Univ. in St Louis Sch. of Med., The autophagy gene Epg5 promotes susceptibility to enteric viral infection

Monday, May 9, 2022 8:00 AM – 10:00 AM Room A107–109

Tissue Inflammation

Chairs

Amanda Jamieson, Brown Univ.
Anna Beaudin, Univ. of Utah Sch. of Med.

Speakers

Bridget Ratitong, Univ. of California, Irvine, The role of IL-1a during early-stage Pseudomonas aeruginosa infection of the corneas
Jingbo Pang, Univ. of Illinois at Chicago, Monocyte/macrophage heterogeneity during skin wound healing in mice
Priyanka Talukdar, Univ. of Pittsburgh, Type III IFNs (IFNλs) expressed in tuberculosis (TB) granulomas enhance anti-mycobacterial activity of macrophages
Meredith Crane, Brown Univ., Pulmonary infection following skin injury delays wound healing through suppression of IL-1 and chemokine production
Vinod Nadella, NIAMS, NIH, The extracellular matrix maintained by hypodermal macrophages via IGF1 is a niche for Staphylococcus aureus infection
Stephanie Seveau, Ohio State Univ. Col. of Med., Inflammatory responses to Listeria monocytogenes infection in the placenta
Marcelina Pyclik, Oklahoma Med. Res. Fndn., STING activation under pre-existing inflammatory conditions causes severe skin disease

Sunday, May 8, 2022 10:15 AM – 12:15 PM Oregon Ballroom 202

Tissue-Resident Memory T Cells (Trm) in Cancer

Chairs

Jose R. Conejo-Garcia, H. Lee Moffitt Cancer Ctr. and Res. Inst.
Fathia Mami-Chouaib, INSERM U1186, France

Speakers

Hui Zhang, Washington State Univ., Tissue-resident memory CD4+ T cells play a dominant role in the initiation of antitumor immunity
Michael J. Gough, Providence Portland Med. Ctr., Tumor resident memory CD8 T cell formation and concomitant tumor immunity is CD40L dependent and CD4 independent
Nu Zhang, Univ. of Texas Hlth. Sci. Ctr. at San Antonio, TGF-β-dependent Lymphoid Tissue Residency of Stem-like T cells Limits the Response to Tumor Vaccine
Carmen Mariam Anadon Galindo, H. Lee Moffitt Cancer Ctr. and Res. Inst., Ovarian cancer immunogenicity is governed by a narrow subset of progenitor tissue-resident memory T-cells
Noah Veis Gavil, Univ. of Minnesota, Chronic antigen in solid tumors drives a distinct program of T cell residence
Fathia Mami-Chouaib, INSERM U1186, France, Resident memory T cells in antitumor immunity and cancer immunotherapy

Sunday, May 8, 2022 3:45 PM – 5:45 PM Oregon Ballroom 203

Transplant Immunology: Novel Mechanisms and Interventions

Chairs

Giorgio Raimondi, Johns Hopkins Univ. Sch. of Med.
Maria-Luisa Alegre, Univ. of Chicago

Speakers

Gavin I. Ellis, Univ. of Pennsylvania, Alloantigen-specific Chimeric Antigen Receptor Regulatory T cell therapy in non-human primate islet transplantation
Feiyan Mo, Baylor Col. of Med., Engineering T cells to prevent graft-versus-host disease and leukemia relapse following allogeneic stem cell transplantation
Caroline Anna Markmann, Perelman Sch. of Med., Univ. of Pennsylvania, Leveraging CAR T cells to achieve desensitization and enable transplantation
Jordan Warunek, Univ. of Pittsburgh Sch. of Med., Paired immunoglobulin-like receptors impact the differentiation of reparative macrophages following allogeneic challenge
Fathima A. Mohamed, Univ. of Minnesota, Targeting temporal metabolic needs of T follicular helper cells to treat cGVHD utilizing a mitochondrial pyruvate carrier inhibitor
Michael Nicosia, Cleveland Clin. Fndn., The role of LAG3 in antibody responses to kidney transplantation
Peter Wang, Univ. of Chicago, Oral alloantigen exposure promotes donor-specific tolerance in a mouse model of minor mismatched skin transplantation
Jared Pollard, Univ. of Chicago, Graft-matched pregnancy imparts profound epigenetic changes onto alloreactive memory t cells to enforce a phenotypic and transcriptional state of tolerance

Friday, May 6, 2022 2:00 PM – 4:00 PM Oregon Ballroom 203

Tumor Immunotherapy (TI1)

Chairs

Eduardo Davila, Univ. of Colorado
Beth Tamburini, Univ. of Colorado Anschutz Med. Campus

Speakers

Subir Biswas, Moffitt Cancer Ctr. and Res. Inst., CAR T cells targeting Olfactory Receptor OR2H1 are an effective immunotherapeutic option in human epithelial tumors
Jiemiao Hu, MD Anderson Cancer Ctr., Cell membrane-anchored and tumor-targeted IL-12 (attIL12)-T cell therapy for eliminating large and heterogeneous solid tumors
Colin J. Thalhofer, AgonOx Inc., Enriching for tumor-reactive CD8 TIL (AGX148) leads to effective tumor clearance in a patient-derived xenograph model
Joey C. Magno, Univ. of Colorado Anschutz Med. Campus, A novel linked TCR:MyD88 receptor improves anti-tumor responses while maintaining antigen specificity
Thomas Duhen, Earle A. Chiles Res. Inst., PD-1 and ICOS co-expression identifies tumor-reactive CD4 Th cells in human solid tumors
Kathryn M. Laporte, Univ. of Miami, Targeting the high-affinity IL-2R with high-dose mIL-2/CD25 induces effective antitumor responses
Silvia Guglietta, Med. Univ. of South Carolina, Complement downregulation promotes an inflammatory signature that renders colorectal cancer susceptible to immunotherapy
Paramita Chakraborty, Med. Univ. of South Carolina, Targeting autophagy with carbon-monoxide reprograms anti-tumor t cells with robust immunometabolic phenotype

Saturday, May 7, 2022 10:15 AM – 12:15 PM Oregon Ballroom 201

Tumor Immunotherapy (TI2)

Chairs

Katelyn T. Byrne, Oregon Hlth. and Sci. Univ.
Ichiko Kinjyo, Univ. of New Mexico

Speakers

Jihae Ahn, Feinberg Sch. of Med., Northwestern Univ., Enhancing the antitumor response of CD8⁺ T cells by 4-1BB (CD137) co-stimulation with distinct inactivation of the type 2 adenosine receptors
Mark E. Issa, Univ. of Montreal, Glycogen synthase kinase (GSK-3) synergizes with PD-1/PDL1 blockade to generate super-armed CD8 killers against tumors
Sora Suzuki, Roswell Park Comprehensive Cancer Ctr., Complement C3 deficiency enhances anti-CD47 efficacy in murine ovarian cancer model
Jasmine E. Trigg, Sartorius, Evaluation of checkpoint inhibitor therapies using a mixed lymphocyte reaction (MLR) assay
Nikolaos E. Patsoukis, Beth Israel Deaconess Med. Ctr., Harvard Med. School, Treatment with exogenously added catalase promotes differentiation and function of central memory CD8⁺ T cells
Allison Christians, Univ. of Colorado Anschutz Med. Campus, DNA-PK inhibition plus immune adjuvants promotes CD8 TIL infiltration, neoantigen presentation, and diversifies the tumor-reactive TCRβ repertoire in B16 melanoma
Ichiko Kinjyo, Univ. of New Mexico, PARP-inhibition with IFNg in the ovarian tumor microenvironment induces immunogenic cancer cell death for sustained anti-tumor immunity

Sunday, May 8, 2022 3:45 PM – 5:45 PM Room B113–116

Tumor Microenvironment (TME) I

Chair

Dorina Avram, H. Lee Moffitt Cancer Ctr. and Res. Inst.

Speakers

Gunjan Mandal, H. Lee Moffitt Cancer Ctr. and Res. Inst., Spontaneous class-switched antibody responses at endometrial cancer tumor bed drives superior patients' outcome
Zihan Guo, Oregon Hlth. and Sci. Univ., Class switching is required for antigen-dependent b cell anti-tumor activity
Zhi-Zhang Yang, Mayo Clin., T-cell phenotype varies in distinct tumor microenvironments and CD57⁺ T_FH cells are associated with disease progression and inferior survival in follicular lymphoma
Juyeun Lee, Cleveland Clin. Fndn., Sex-specific T cell behavior drives differential immune responses in mouse glioblastoma models
Stephanie Gomez, George Washington Univ., Inhibition of DNMTs and RNA editing increases immunogenic transposable element RNA to reduce tumor burden and prolong survival in a murine ovarian cancer model
Tahereh Ziglari, Oregon Hlth. and Sci. Univ., Senescent cell-derived extracellular vesicles are critical elements in senescence surveillance by recruiting antigen-presenting cells
Thejaswini Giridharan, Roswell Park Comprehensive Cancer Ctr., Role of the extracellular ATP/adenosine pathway in neutrophil-mediated T cell suppression in ovarian cancer microenvironment

Tuesday, May 10, 2022 10:15 AM – 12:15 PM Room B113–116

Tumor Microenvironment (TME) II

Chairs

Ronald Buckanovich, Univ. of Pittsburgh
Fabiola Osorio, Univ. of Chile

Speakers

Holly Morrison, Col. of Vet. Med., Virginia Tech, Diminished noncanonical NF-κB signaling induces colitis-associated colorectal cancer susceptibility upon de-differentiation of epithelial cells
Sandra Cascio, Univ. of Pittsburgh Sch. of Med., Egfl6 promotes ovarian cancer progression by inducing the immunosuppressive functions of tumor-infiltrating myeloid cells.
Asima Abidi Radboudumc, Dendritic cells to prevent cancer: Immune responses against neoantigens after dendritic cell vaccination of Lynch Syndrome patients
Manisha Taya, Univ. of Texas Southwestern Med. Ctr., Ovarian cancer cell glucocorticoid receptor activity modulates cytokine secretion promoting infiltration of immunosuppressive cells into the tumor microenvironment
Megan Snyder, Boston Univ. Sch. of Med., Malignant cell expression of the aryl hydrocarbon receptor induces PD-L1 and immunosuppression in models of oral and lung cancer
Ellis, J. Tibbs, Univ. of Maryland Sch. of Med., Pro-tumoral role of Granzyme B to aid in invasion and metastasis.
Erin Gibbons, Univ. of Rochester Med. Ctr., Glycoprotein-NMB (GPNMB) is Pro-Tumorigenic in Lymphangioleiomyomatosis (LAM)
David Shihong Gao, Univ. of Pittsburgh Sch. of Med., Loss of p53 sensitizes tumor cells to immune checkpoint blockade therapy via upregulation of IL-33

Sunday, May 8, 2022 3:45 PM – 5:45 PM Oregon Ballroom 204

Vaccination and Immunotherapy against COVID-19

Chairs

Donna L. Farber, Columbia Univ. Med. Ctr.
James J. Kobie, Univ. of Alabama at Birmingham

Speakers

Ebony Nicole Gary, Wistar Inst., Peripheral co-immunization with CCL27 drives robust mucosal responses to SARS-CoV-2 synDNA antigens and provides heterologous protection against Delta variant challenge
Vanessa S. Moraes, Univ. of Georgia, Polyfunctionality of T cell immunity in pre-immune and naïve individuals after COVID-19 mRNA vaccination
Elizabeth A. Thompson, Johns Hopkins Univ. Sch. of Med., Alternative lineage B cells utilizing fatty acid oxidation predict response to third dose COVID vaccination in solid organ transplant recipients
James Kobie, Univ. of Alabama at Birmingham, Pan-coronavirus neutralizing S2 human monoclonal antibodies and utility of direct respiratory administration as combination therapy with S1 antibodies against SARS-CoV-2
Timothy A. Bates, Oregon Hlth. and Sci. Univ., Hybrid immunity and vaccine breakthrough lead to robust humoral response and antibodies that effectively neutralize SARS-CoV-2 variants
Eric S. Geanes, Children's Mercy Kansas City, Differences between autoantibodies induced by SARS-CoV-2 infection and Pfizer-BioNTech SARS-CoV-2 vaccination
Julia Davis-Porada, Columbia Univ. Med. Ctr., Persistence of immune memory to SARS-CoV-2 vaccine in lymphoid tissue
John D. Mountz, Univ. of Alabama at Birmingham, IL-4R blockade prevents a long term memory B cell response to COVID-19 vaccination

Sunday, May 8, 2022 12:30 PM – 2:30 PM Oregon Ballroom 202

Vaccines and Immunity against Bacteria and Parasites

Chairs

JoAnne L. Flynn, Univ. of Pittsburgh Sch. of Med.
David A. Rosen, Washington Univ. Sch. of Med.

Speakers

Yanli Li, Univ. of North Carolina at Chapel Hill, Identification of CPAF as the immunoprevalent antigen of Chlamydia trachomatis
Jaikin Harrell, Tulane Univ. Sch. of Med., The use of outer membrane vesicles as novel, mucosal adjuvants against intracellular bactiera
Matthew Bell, Drexel Univ. Col. of Med., The novel adjuvant, ADA-1, restores age-associated defects in the adaptive immune response to Clostridioides difficile infection and vaccination in an aging mouse model
Valery Cristina Román-Cruz, Univ. of Montana, Adjuvanted multivalent vaccine targeting clinically relevant Pf bacteriophage creates cross-reactive antibodies
Paeton L. Wantuch, Washington Univ. Sch. of Med., Differential Immune Response to Klebsiella pneumoniae O-antigen subtypes O2v1 and O2v2
Andrew W. Simonson, Univ. of Pittsburgh Sch. of Med., The role of lymphocyte subsets in preventing tuberculosis following intravenous vaccination with BCG
Eva Morgun, Feinberg Sch. of Med., Northwestern Univ., Mycolic acid nanoparticle vaccination leads to antigen persistence and unique differentiation of mycobacterial lipid antigen-specific T cells
Caroline J. Duncombe, Univ. of Washington, Differential sex-specific immune responses following Prime-and-Trap vaccination alters protection against malaria in mice

Friday, May 6, 2022 2:00 PM – 4:00 PM Oregon Ballroom 201

Vaccines and Immunobiologics against Viruses

Chair

Fikadu G. Tafesse, Oregon Hlth. and Sci. Univ.

Speakers

Angela Desmond, Children's Hosp. of Philadelphia, Preventing neonatal herpes: Protection after maternal mRNA-lipid nanoparticle vaccination equals or exceeds that from prior maternal genital infection in murine models
Ninaad Lasrado, Univ. of Nebraska-Lincoln, A live-attenuated mutant CVB3 vaccine virus protects against multiple coxsackievirus B infections
Laura Stephens, Univ. of Iowa, Robust efficacy and long-lasting humoral immunity induced by a respiratory syncytial virus prefusion F-based nanoparticle vaccine in genetically diverse animal models
Yinyan Xu, Univ. of North Carolina at Chapel Hill, Conserved-region MVA vaccines can shift HIV T cell immunodominance in PWH on ART—the M&M Study
Celeste Huaman, Uniformed Services Univ., Control of established, CNS-resident lyssavirus infection by an adaptive immune response stimulated by single-dose monoclonal antibody therapy
Husam Taher, Oregon Hlth. and Sci. Univ., T cell programming by the cytomegalovirus MHC class I homologue UL18
Ramireddy Bommireddy, Emory Univ. Sch. of Med., Influenza virus-like particle-based hybrid vaccine containing RBD induces immunity against influenza and SARS-CoV-2 viruses
Marta C. Cruz Cisneros, Univ. of North Carolina at Chapel Hill, Genetic analysis of differential responses to adjuvanted influenza vaccination

Block Symposia

Tuesday, May 10, 2022 10:15 AM – 12:15 PM Room C123–124

Adaptive Immunity in Inflammation

Friday, May 6, 2022 2:00 PM – 4:00 PM Room A107–109

Antigen Processing and Presentation I

Tuesday, May 10, 2022 8:00 AM – 10:00 AM Room A107–109

Antigen Processing and Presentation II

Saturday, May 7, 2022 3:45 PM – 5:45 PM Room B110–112

Autoantigen Identification, Autoantigen Specificity, and Central Tolerance

Saturday, May 7, 2022 10:15 AM – 12:15 PM Oregon Ballroom 203

Autoimmunity

Saturday, May 7, 2022 3:45 PM – 5:45 PM Room B117–119

B and T Cell Development

Sunday, May 8, 2022 8:00 AM – 10:00 AM Oregon Ballroom 202

B Cell and T Cell Helper Responses during Viral Infections

Tuesday, May 10, 2022 8:00 AM – 10:00 AM Room B117–119

B Cell Differentiation, Regulation, and Function

Sunday, May 8, 2022 8:00 AM – 10:00 AM Room B113–116

Big Data: The Key to Unlocking Immune Mediated Mechanisms of Tumor Progression and Therapy Response

Monday, May 9, 2022 8:00 AM – 10:00 AM Room C123–124

CD4+ T Cell Regulation and Responses: Molecular Mechanisms

Sunday, May 8, 2022 3:45 PM – 5:45 PM Room A105–106

CD4+ T Cells in Cancer

Sunday, May 8, 2022 3:45 PM – 5:45 PM Oregon Ballroom 201

CD8+ T Cell Immunity to Viral Infections

Monday, May 9, 2022 3:45 PM – 5:45 PM Oregon Ballroom 201

CD8+ T Cells in Cancer

Tuesday, May 10, 2022 10:15 AM – 12:15 PM Room A107–109

Cells of the Innate Immune System

Tuesday, May 10, 2022 8:00 AM – 10:00 AM Room C123–124

Cytokine and Chemokine Control of Cellular Immunity

Monday, May 9, 2022 10:15 AM – 12:15 PM Room A105–106

Cytokine and Regulatory Cell Control of Autoimmunity

Saturday, May 7, 2022 8:00 AM – 10:00 AM Oregon Ballroom 201

Engineering Immunoreceptor and Cytokine Signaling for Therapeutics

Monday, May 9, 2022 10:15 AM – 12:15 PM Oregon Ballroom 202

Food Allergy, Atopic Dermatitis, and Mast Cells, Oh My!

Saturday, May 7, 2022 8:00 AM – 10:00 AM Room A107–109

From Sharks, Fish, and Frogs to Mammals: Fascinating Immunological Discoveries

Friday, May 6, 2022 2:00 PM – 4:00 PM Room B117–119

HSCs and Myelopoiesis

Friday, May 6, 2022 2:00 PM – 4:00 PM Room B113–116

Immune-Based Therapeutics for Neurological Disease

Tuesday, May 10, 2022 10:15 AM – 12:15 PM Room B117–119

Immunity to Microbial, Parasitic, and Fungal Infections I

Saturday, May 7, 2022 12:30 PM – 2:30 PM Room B113–116

Immunity to Microbial, Parasitic, and Fungal Infections II

Saturday, May 7, 2022 12:30 PM – 2:30 PM Oregon Ballroom 201

Immunity to SARS-CoV-2

Friday, May 6, 2022 2:00 PM – 4:00 PM Room C123–124

Immunoregulation—General

Saturday, May 7, 2022 12:30 PM – 2:30 PM Room A105–106

Immunoregulation—Infection and Immunity

Tuesday, May 10, 2022 8:00 AM – 10:00 AM Room B110–112

Immunoregulation—Innate Immune Responses

Friday, May 6, 2022 2:00 PM – 4:00 PM Room A105–106

Immunoregulation—Mechanism of Action

Sunday, May 8, 2022 8:00 AM – 10:00 AM Oregon Ballroom 201

Infection and Disease

Monday, May 9, 2022 10:15 AM – 12:15 PM Room A107–109

Innate Immune Response to Infection

Monday, May 9, 2022 12:30 PM – 2:30 PM Room B117–119

Innate Immune Sensing and Signaling

Sunday, May 8, 2022 12:30 PM – 2:30 PM Oregon Ballroom 203

Innate Immunity to Viral Infection

Monday, May 9, 2022 10:15 AM – 12:15 PM Oregon Ballroom 203

Innate Lymphocytes and Innate-Like T Cells in Cancer

Sunday, May 8, 2022 12:30 PM – 2:30 PM Room B110–112

Innate Signaling, Microbiome, and Metabolism in Autoimmunity

Tuesday, May 10, 2022 10:15 AM – 12:15 PM Room B110–112

Lymphocyte Homeostasis and Regulation

Monday, May 9, 2022 10:15 AM – 12:15 PM Oregon Ballroom 201

Macrophages, Myeloid, and Dendritic Cells in Tumor Immunity and Immunotherapy

Saturday, May 7, 2022 8:00 AM – 10:00 AM Room B113–116

Mechanisms of Resistance to Therapy

Monday, May 9, 2022 8:00 AM – 10:00 AM Oregon Ballroom 202

Mechanisms of Viral Sensing and Innate Immune Responses

Friday, May 6, 2022 2:00 PM – 4:00 PM Oregon Ballroom 202

Memory T Cell Differentiation, Function, and Maintenance

Monday, May 9, 2022 8:00 AM – 10:00 AM Room A105–106

CD4⁺ T Cell Regulation and Responses: Molecular Mechanisms

CD4⁺ T Cells in Cancer

CD8⁺ T Cell Immunity to Viral Infections

CD8⁺ T Cells in Cancer