IMMUNOLOGY2022™

May 6–10, 2022 | Portland, Oregon

Blocks Saturday, May 7, 2022

Block Symposia

Full Listing
Fri. May 6
Sat. May 7
Sun. May 8
Mon. May 9
Tue. May 10

Saturday, May 7, 2022

 Saturday, May 7, 2022     8:00 AM – 10:00 AM     Oregon Ballroom 201

Engineering Immunoreceptor and Cytokine Signaling for Therapeutics

Chairs

  • Ingunn Stromnes, Univ. of Minnesota
  • Carl Ware, Sanford Burnham Prebys Med. Discovery Inst.

Speakers

  • Nina Beryl Horowitz, Stanford Univ., Overcoming barriers to solid tumor immunotherapy using natural killer cell therapies designed to mimic intraepithelial group 1 innate lymphoid cells
  • Meagan R. Rollins, Univ. of Minnesota Med. Sch., Adoptive transfer of Trac-targeted T cell receptor engineered T cells with defective Tgfbr2 signaling promotes pancreatic cancer eradication
  • Karen Michelle Christie, Univ. of Delaware, Directing T cell alloreactivity against solid tumors through tumor antigen dependent TCR expression
  • Zachariah Peter Tritz, Mayo Clin. Grad. Sch. of BioMed. Sci., Combination of αPD-1 and extended half-life IL-2 is effective against the GL261 glioma and uniquely reverses GBM-associated immunosuppression
  • Travis J. Shute, UT Hlth. San Antonio, Glycolipid-loaded nanoparticle immunotherapy cooperates with checkpoint inhibitors to harness iNKT cells for tumor control
  • Aliyah Brianne Silver, Johns Hopkins Bloomberg Sch. of Public Hlth., A tumor-targeted cytokine/antibody fusion protein to stimulate anti-cancer immunity
  • Kyle Alexander Romine, Oregon Hlth. and Sci. Univ., BET inhibitors synergize with anti-PD1 by rescuing TCF1+ progenitor exhausted T cells in acute myeloid leukemia
  • Hien T. Huynh, Univ. of Missouri Columbia, Dissecting molecular mechanisms underlying T cell co-potentiation when targeting the TCR/CD3 complex with anti-CD3 Fab fragments
 Saturday, May 7, 2022     8:00 AM – 10:00 AM     Room A107–109

From Sharks, Fish, and Frogs to Mammals: Fascinating Immunological Discoveries

Chairs

  • Renukaradhya Gourapura, The Ohio State Univ.
  • Rob Miller, Univ. of New Mexico

Speakers

  • Aryana Razmara, Univ. of California, Davis, Optimization of expansion techniques for adoptive NK cell transfer in dogs with cancer
  • Kimberly A. Morrissey, Univ. of New Mexico, The biology of the unconventional γμ T cell in the opossum Mondodelphis domestica
  • Renukaradhya J. Gourapura, Ohio State Univ., Plant derived Nano-11 particle adsorbed with stimulator of interferon genes adjuvant and split influenza virus antigens elicits the cross-protective immunity in pigs
  • Jordan M. Sampson, Univ. of New Mexico, B cell ontology in a model marsupial
  • Ahmed Attaya, Univ. of Massachusetts Lowell, scRNA-Seq profiling of stickleback fish splenocytes: expansion of myeloid and B cells on immunization
  • Matthieu Paiola, Univ. of Rochester Med. Ctr., Flt3 and its ligand as an ancient regulators of dendritic cells: evidence in the amphibian Xenopus laevis
  • Hanover C. Matz, Univ. of Maryland, Baltimore, B cell selection sites in the nurse shark spleen may represent evolutionary precursors of mammalian germinal centers
  • Yvonne Drechsler, Western Univ. of Hlth. Sci., Characterization of cellular subpopulations and their gene expression by single-cell RNA sequencing in canine atopic dermatitis
 Saturday, May 7, 2022     8:00 AM – 10:00 AM     Room B113–116

Mechanisms of Resistance to Therapy

Chairs

  • Jim Song, Texas A&M Univ.
  • William Lu, Univ. of Arkansas for Med. Sci.

Speakers

  • Arshmeet K. Chawla, Univ. of Connecticut Hlth. Ctr., β-adrenergic signaling modulates the development and activity of erythroid suppressor cells
  • Jianmei Wu Leavenworth, Univ. of Alabama at Birmingham, Remodeling of the tumor microenvironment via disrupting effector Treg activity augments response to checkpoint blockade
  • Avery Janese Salmon, Univ. of Texas MD Anderson Cancer Cntr. UTHealth Grad. Sch. of Biomed. Sci., BHLHE40: Required for regulation of effector T cells and remodeling of tumor microenvironment during immune checkpoint therapy
  • Adam L. Burrack, Univ. of Minnesota, TNF-α blockade improves immunotherapy efficacy by altering the tumor microenvironment and enhancing tumor-specific T cell function in pancreatic ductal adenocarcinoma
  • Nathan E. Reticker-Flynn, Stanford Univ. Sch. of Med., Lymph node colonization promotes distant tumor metastasis through the induction of tumor-specific immune tolerance
  • Evelyn M. Nguyen, Mem. Sloan Kettering Cancer Ctr., Targeting LSD1 rescues MHC class I antigen presentation and promotes immune checkpoint blockade response in small cell lung cancer
  • Vishnu Modur, Cincinnati Children’s Hosp. Med. Ctr., Tumors bearing defective transcription elongation are immune hot but resistant to immune checkpoint inhibitors
 Saturday, May 7, 2022     8:00 AM – 10:00 AM     Oregon Ballroom 203

Molecular Mechanisms of Cytokine Function

Chairs

  • Laurie E. Harrington, Univ. of Alabama at Birmingham
  • Gail Bishop, Univ. of Iowa

Speakers

  • Nicholas N. Jarjour, Univ. of Minnesota Med. Sch., Common gamma chain-dependent cytokines drive antigen-independent proliferation of circulating and resident memory CD8+ T cells
  • Rosanne Spolski, NHLBI, NIH, Distinct super-enhancer elements differentially control Il2ra gene expression in a cell-type specific fashion
  • Milos Vujanac, Univ. of Miami Miller Sch. of Med., Regulation of IL-2- and IL-6-dependent signaling in human Tregs by CISH and SOCS3
  • Emma Hornick, Univ. of Iowa, TRAF3 enhances type I interferon (IFN I) receptor signaling in T cells through modulation of the phosphatase PTPN22
  • Harold A. Silverman, Feinstein Institutes for Med. Research, Northwell Hlth., Transient receptor potential ankyrin 1 (TRPA1) mediates IL-1β-induced thermoregulation
  • Sonya Wolf, Michigan Med. at Univ. of Michigan, Interferon kappa (IFNk) in keratinocytes is critical for normal wound repair and is decreased in diabetic wounds
  • Emily A. Dennis, Univ. of Virginia, Loss of ten-eleven translocation 2 (TET2) reduces CCR6 expression and increases B1 B cell number in the peritoneal cavity
  • Audrey Kwun, Cleveland Clin. Fndn., Sustained NPSLE development in the absence of systemic lupus-like disease in TLR7-deficient B6.Nba2
 Saturday, May 7, 2022     8:00 AM – 10:00 AM     Room B110–112

Regulation of B and T Cells in Autoimmune Diseases

Chairs

  • Hubert M.Tse, Univ. of Alabama at Birmingham
  • Virginia Shapiro, Mayo Clin.

Speakers

  • Tracoyia A.Roach, Univ. of Florida, Lupus susceptibility gene pbx1 regulates stat3 in T cells via jak2/stat3 signaling pathway
  • Hu Zeng, Mayo Clin. Col. of Med. and Sci., mTORC2 contributes to murine lupus associated immunopathology
  • Anne B. Satterthwaite, Univ. of Texas Southwestern Med. Ctr., B cell subsets contributing to the autoreactive plasma cell pool in Lyn-/- mice
  • Samuel I. Blum, Univ. of Alabama at Birmingham, NADPH oxidase-derived superoxide promote autoreactive T cell infiltration into islets of prediabetic NOD mice
  • Stephanie J. Grebinoski, Univ. of Pittsburgh Sch. of Med., Intra-islet CD8+ T cells are restrained by an exhaustion program that can be partially reversed in the absence of LAG3
  • Alexander W. Boyden, Univ. of Iowa Carver Col. of Med., B cell-mediated antigen presentation is required to induce functional pathogenicity of CD4 T cells in a proteolipid protein mouse model of multiple sclerosis
  • Sydney B. Crotts, Mayo Clin., Regulation of inflammatory bowel disorder by ST8Sia6
  • Yuying Liu, McGovern Med. School, Univ. of Texas Hlth. Sci. Ctr. at Houston, Phenotype of CD39/CD73 expressed on T cells in a mouse model of IPEX syndrome
 Saturday, May 7, 2022     8:00 AM – 10:00 AM     Room A105–106

Technological Innovations in Immunology I

Chairs

  • Yuri Sykulev, Thomas Jefferson Univ.
  • Amanda M. Burkhardt, Univ. Southern California

Speakers

  • Yunhao Zhai, Wyss Inst. for Biologically Inspired Engin. at Harvard Univ., A human ectopic-lymphoid-follicle-on-a-chip for testing vaccines and adjuvants
  • Armando Javier Arroyo-Mejías, NIAID, NIH, 3D-IBEX: achieving multiplex 3-dimensional imaging for deep phenotyping of cells in tissues
  • Yuri Sykulev, Thomas Jefferson Univ., CD16 and NKG2D co-clustering facilitates quality of primary NK cell responses
  • Tim Le Fevre, STEMCELL Technologies, Inc., Generation of large numbers of functional NK cells without feeders or serum
  • Hing C. Wong, HCW Biologics, A feeder cell-free activation and expansion strategy to generate memory-like NK cells sufficient for off-the-shelf multi-dose adoptive cell therapy
  • Timothy C. Borbet, New York Univ. Sch. of Med., Leveraging mouse genetics to generate heavy-chain only antibodies for therapeutic application
  • Michael J.T. Stubbington, 10x Genomics, Discovery of potently-neutralizing antibodies against SARS-CoV-2 using Barcode Enabled Antigen Mapping (BEAM)
 Saturday, May 7, 2022     8:00 AM – 10:00 AM     Room C123–124

They Come and They Go: A Leukocyte Migration Extravaganza

Chairs

  • Judy Cannon, Univ. of New Mexico
  • Michael Gerner, Univ. of Washington

Speakers

  • Zev Joshua Greenberg, Washington Univ. in St Louis Sch. of Med., The tetraspanin CD53 as a novel regulator for B cell trafficking
  • Tonya Aaron, Albert Einstein Col. of Med., Inflammation depletes humoral immunity by limiting plasma cell access to the bone marrow survival niche
  • Paulus Mrass, Univ. of New Mexico, CXCR4 promotes the stop signal and degranulation of cytotoxic T cells infiltrating influenza-infected lungs
  • Farhat Parween, NIAID, NIH, CCR2 identifies two subtypes of pathogenic human type 17 Th cells and has a non-redundant role in their transendothelial migration
  • Wenji Piao, Univ. of Maryland Sch. of Med., PD-1 licenses activated Treg for lymphatic migration
  • Michael Y. Gerner, Univ. of Washington, Dendritic cells regulate innate cell trafficking into lymph nodes during inflammationM
  • Lai Wen, La Jolla Inst. for Immunology, A new β2 integrin activation reporter mouse reveals localized intra- and extra-vascular neutrophil integrin activation in vivo
  • Hemant Joshi, Washington Univ. in St. Louis Sch. of Med., Mechanical stress modulates NLRP3 pathway in macrophages
 Saturday, May 7, 2022     10:15 AM – 12:15 PM     Oregon Ballroom 203

Autoimmunity

Chairs

  • Veena Taneja, Mayo Clin.
  • Hsin-Jung Wu, The Ohio State Univ. Col. of Med.

Speakers

  • Jacob William Shelton Martens, Univ. of Michigan, The role of skin-derived IFN-kappa in the development of systemic autoimmunity
  • Jonathan D. Crawford, Johns Hopkins Univ. Sch. of Med., XIST is a source of TLR7 ligands underlying the sex bias in Systemic Lupus Erythematosus
  • Nirmal K. Banda, Univ. of Colorado Anschutz Med. Campus, A snap shot of complement gene expression and presence of complement proteins in synovial biopsies from early rheumatoid arthritis patients
  • Diego A. Espinoza, Perelman Sch. of Med., Univ. of Pennsylvania, Proteogenomic immune signatures delineate the landscape of pediatric acquired demyelinating syndromes
  • Bonnie Blomberg, Univ. of Miami Miller Sch. of Med., Old mice and elderly humans make increased autoimmune antibodies, inflammation and SASP from aged-increased B cells (ABCs in mice and DN in humans) which are hypermetabolic
  • Sarah Alice Long, Benaroya Res. Inst., CD8 T cell exhaustion is reduced in subjects with autoimmune-associated DR4 risk alleles
  • Adebowale Bamidele, Mayo Clin. Rochester, Metabolic dysfunction governs regulatory t cell inflammatory response during inflammatory bowel disease
  • Alice E. Wiedeman, Benaroya Res. Inst., Differential therapeutic modulation of exhaustion among autoreactive and global CD8 T cells in type 1 diabetes (T1D)
 Saturday, May 7, 2022     10:15 AM – 12:15 PM     Room C123–124

Molecular and Cellular Control of Humoral Immunity

Chairs

  • Wei Luo, Indiana Univ. Sch. of Med.
  • Patricia Gearhart, NIA, NIH

Speakers

  • Carlos J. Ticas Rodas, NIA, NIH, Follicular B cells from old mice are hyper-responsive and produce non-specific antibodies
  • Christian Cervantes, Univ. of Texas Hlth. Sci. Ctr. San Antonio, PD-L1 plays a B cell-intrinsic role in suppressing the antibody response and anti-tumor immunity
  • Wei Luo, Indiana Univ. - Sch. of Med., Blimp1 controls GC B cell expansion and exit through regulating cell cycle progression and key transcription factors BCL6 and IRF4
  • Kim Good-Jacobson, Monash Univ., Targeting intrinsic regulators of antibody and B cell memory to control chronic viral infection
  • William Voss, Univ. of Texas at Austin, Differential serological immune imprinting following SARS-CoV-2 infection, vaccination, and breakthrough infection
  • Brian T. Gaudette, Perelman Sch. of Med., Univ. of Pennsylvania, The plasma cell proteome initiates early in B cell activation in advance of Blimp-1
  • J. Scott Hale, Univ. of Utah Sch. of Med., Tet2-mediated programing balances T follicular helper cell and T helper 1 cell differentiation
  • Nicole M. Arroyo, Univ. of Alabama at Birmingham, A temporal switch in T follicular helper cells controls the output of the GC response to influenza
 Saturday, May 7, 2022     10:15 AM – 12:15 PM     Oregon Ballroom 202

Pathogenesis of SARS-CoV-2 Infection

Chairs

  • Amelia Pinto, Saint Louis Univ. Sch. of Med.
  • Majid Kazemian, Purdue Univ.

Speakers

  • Elizabeth Geerling, St. Louis Univ., Sch. of Med., Metabolic syndrome enhances viral disease severity and reduces vaccine efficacy in mice
  • Jian Zheng, Univ. of Iowa, Eicosanoid signaling as a therapeutic target in middle-aged mice with severe COVID-19
  • Stephen T. Yeung, Weill Cornell Grad. Sch. of Med. Sci., Galectin-9 protects humanized-ACE2 immunocompetent mice from SARS-CoV-2 Infection
  • Bingyu Yan, Purdue Univ., SARS-CoV-2 drives JAK1/2-dependent local complement hyperactivation
  • Ksenia Rybkina, Columbia Univ. Med. Ctr., Children with Multi-System Inflammatory Syndrome (MIS-C) develop functionally competent T cell memory against SARS-CoV-2 following recovery
  • Zehra Rahman, Univ. at Buffalo Sch. of Med. and BioMed. Sci., Exploration of shared antibody motifs in Kawasaki Disease (KD) and COVID-19 related Multisystem Inflammatory Syndrome of Childhood (MIS-C)
  • Brandi L. Clark, St. Jude Children's Res. Hosp., Identifying distinct T cell subsets in the context of pediatric ARDS
  • Yu Gao, Karolinska Inst., SARS-CoV-2 mRNA vaccination induces polyfunctional T cell responses in healthy and immunocompromised individuals
 Saturday, May 7, 2022     10:15 AM – 12:15 PM     Oregon Ballroom 204

Tissue Immunity at Barrier Sites

Chairs

  • Gianna E. Hammer, Duke Univ.
  • Shipra Vaishnava, Brown Univ.

Speakers

  • Michael Stolley, Univ. of Minnesota, Leveraging resident memory t cells to fortify oral immunity
  • Gabriel Antonio Ascui-Gac, La Jolla Inst. for Immunology, RAMP3 unexplored relevance for innate-T cell immunity
  • Colette Matysiak, Harvard Med. Sch., Intranasal, not parenteral, vaccination induces the formation of tissue-resident memory CD8 T cells in nasal mucosa that rapidly clear influenza virus infection
  • Tanvi Arkatkar, Univ. of Washington, Bystander CD8 T cell memory responses partially protect mice against lethal vaginal HSV-2 challenge
  • Vineet Joag, Univ. of Minnesota, Sensing and alarm function of vaccine-elicited SIV-gag specific CD8 TRM in the reproductive mucosa of rhesus macaques
  • Elaine Kouame, Univ. of Chicago, The miseducation of T cells in autoimmunity
  • Ziqi Chen, Harvard Med. Sch., Parenteral vaccination strategies target protective immunity to the small and large intestine mucosa
  • Gowri Kalugotla, Washington Univ. in St Louis Sch. of Med., The autophagy gene Epg5 promotes susceptibility to enteric viral infection
 Saturday, May 7, 2022     10:15 AM – 12:15 PM     Oregon Ballroom 201

Tumor Immunotherapy (TI2)

Chairs

  • Katelyn T. Byrne, Oregon Hlth. and Sci. Univ.
  • Ichiko Kinjyo, Univ. of New Mexico

Speakers

  • Jihae Ahn, Feinberg Sch. of Med., Northwestern Univ., Enhancing the antitumor response of CD8+ T cells by 4-1BB (CD137) co-stimulation with distinct inactivation of the type 2 adenosine receptors
  • Mark E. Issa, Univ. of Montreal, Glycogen synthase kinase (GSK-3) synergizes with PD-1/PDL1 blockade to generate super-armed CD8 killers against tumors
  • Sora Suzuki, Roswell Park Comprehensive Cancer Ctr., Complement C3 deficiency enhances anti-CD47 efficacy in murine ovarian cancer model
  • Jasmine E. Trigg, Sartorius, Evaluation of checkpoint inhibitor therapies using a mixed lymphocyte reaction (MLR) assay
  • Nikolaos E. Patsoukis, Beth Israel Deaconess Med. Ctr., Harvard Med. School, Treatment with exogenously added catalase promotes differentiation and function of central memory CD8+ T cells
  • Allison Christians, Univ. of Colorado Anschutz Med. Campus, DNA-PK inhibition plus immune adjuvants promotes CD8 TIL infiltration, neoantigen presentation, and diversifies the tumor-reactive TCRβ repertoire in B16 melanoma
  • Ichiko Kinjyo, Univ. of New Mexico, PARP-inhibition with IFNg in the ovarian tumor microenvironment induces immunogenic cancer cell death for sustained anti-tumor immunity
 Saturday, May 7, 2022     12:30 PM – 2:30 PM     Room B113–116

Immunity to Microbial, Parasitic, and Fungal Infections II

Chairs

  • De'Broski Herbert, Univ. of Pennsylvania Sch. of Vet. Med.
  • Tracey Lamb, Univ. of Utah

Speakers

  • Jenna Reed, Univ. of Utah Sch. of Med., Plasmodium infection elevates risk of severe secondary bacterial disease by altering the immunological landscape of the lung
  • Oscar Rosas Mejia, Ohio State Univ. Col. of Med., Mice infected with Mycobacterium tuberculosis are resistant to secondary infection with SARS-CoV-2
  • Nicolas Olive Jean Millet, Harbor-Univ. of California, Los Angeles Med. Cntr., IL-23 signaling limits ferroptosis-driven immunopathology during systemic fungal infection
  • Trung Hoang Minh Pham, Stanford Univ. Sch. of Med., Single-cell profiling identifies ACE+ granuloma macrophages as a non-permissive niche for intracellular bacteria during persistent Salmonella infection
  • Yazmin Berenice Martinez-Martinez, Univ. of Texas Med. Br. at Galveston, HIV compromises Th17 and Th22 immunity in a humanized mouse model of Tuberculosis and HIV co-infection
  • E. Evonne Jean, Univ. of Pennsylvania Sch. of Vet. Med., Exploring cutaneous neuro-immune networks during helminth infection
  • Nana K. Minkah, Seattle Childrens Res. Inst., Type I Interferon remodels intrahepatocytic signaling to promote T cell dysfunction during liver stage Plasmodium infection
  • Romaniya Zayats, Univ. of Manitoba, Cellular dynamics of immune evasion during Leishmania major infection
 Saturday, May 7, 2022     12:30 PM – 2:30 PM     Oregon Ballroom 201

Immunity to SARS-CoV-2

Chairs

  • Emily Hemann, The Ohio State Univ., Col. of Med.
  • Paul Thomas, Saint Jude Children's Res. Hosp.

Speakers

  • Abigail Solstad, Ohio State Univ., Endogenous interferon-lambda signaling restricts virus replication and disease severity in a murine model of SARS-CoV-2 infection
  • Jodi F. Hedges, Montana State Univ., ADAM-17 protease promotes inflammation and mortality while decreasing viral burden in a COVID-19 mouse model
  • Xiao He, Univ. of Utah, A longitudinal study of humoral immune responses to SARS-CoV-2 spike proteins in gamma-interferon-inducible lysosomal thiol reductase deficient mice
  • Hejun Liu, Scripps Res. Inst., The human IGHD3-22 encoded motif contributes to broad reactivity of anti-SARS-CoV-2 antibodies
  • Jennifer R. Habel, Univ. of Melbourne, at Peter Doherty Inst. for Infection and Immunity, Integrated immune networks in SARS-CoV-2 infected pregnant women reveal differential NK cell and unconventional T cell activation
  • Krista L. Newell, SUNY Upstate Med. Univ., Spike BATTLE: Simultaneous evaluation of antigen-specific B and T lymphocytes following natural SARS-CoV-2 infection and subsequent mRNA vaccination
  • Alba Grifoni, La Jolla Inst. for Immunology, SARS-CoV-2 vaccination induces T cell memory responses able to cross-recognize ongoing SARS-CoV-2 variants including omicron
  • Anastasia Minervina, St. Jude Children's Res. Hosp., Epitope-specific T cell response to SARS-CoV-2 infection and vaccination
 Saturday, May 7, 2022     12:30 PM – 2:30 PM     Room A105–106

Immunoregulation—Infection and Immunity

Chairs

  • Benjamin Hurrell, Univ. of Southern California
  • Omid Akbari, Keck Sch. of Med., Univ. of Southern California

Speakers

  • Karine Bouchard, Quebec Heart and Lung Inst., Université Laval, Macrophage inflammatory response increases in adult female exposed to neonate stress
  • Hector M. Nieves-Rosado, Univ. of Pittsburgh Sch. of Med., Tim-3 deletion on Treg increases virus-specific T cell response and reduces viral burden in chronic LCMV infection
  • Kunal Dhume, Univ. of Central Florida, Robust homotypic and heterosubytpic immunity against Influenza A Virus in mice lacking Th1/Tc1 transcriptional machinery
  • Manuja Gayashan Bandara Gunasena, Ohio State Univ., Immune determinants of cardiometabolic risk in pre-existing type-2 diabetes (T2D) severe COVID-19 patients
  • Monique M. Waldman, Univ. of Colorado Anschutz Med. Campus, Ena/VASP protein-mediated actin polymerization contributes to naive CD8+ T cell activation and expansion by promoting T cell-APC interactions in vivo
  • Mahmoud Abdelbary, Oregon Hlth. and Sci. Univ., Core fucosylation of N-linked glycans: a novel player in memory CD8+ T cell differentiation following acute viral infection
  • Thu A. Doan, Univ. of Colorado Anschutz Med. Campus, Archived antigen boosts CD8 T cell memory responses during an unrelated infection
 Saturday, May 7, 2022     12:30 PM – 2:30 PM     Oregon Ballroom 202

The Ins and Outs of Airway Inflammation

Chairs

  • Rebecca Martin, Virginia Commonwealth Univ.
  • De'Broski Herbert, Univ. of Pennsylvania Sch. of Vet. Med.

Speakers

  • Jorge F. Ortiz-Carpena, Perelman Sch. of Med., Univ. of Pennsylvania, Sensory neurons shape allergic Type 2 inflammation in the sinonasal tract
  • Anukul T. Shenoy, Boston Univ., Mouse model of late-onset neutrophilic asthma reveals an epithelium-lymphocyte-neutrophil communication circuit underlying destructive airway neutrophilia
  • Jihyun Yu, Korea Advanced Inst. of Sci. and Technol., GPR43 signaling in lung eosinophils suppresses neutrophilic airway inflammation in asthma
  • Rama Krishna Gurram, NHLBI, NIH, TSLP and IL-33 distinctively modulate the allergic response by differentially modulating Th2 cells and ILC2sM
  • Anuj Tharakan, Virginia Commonwealth Univ. Sch. of Med., Blockade of dendritic cell glutaminolysis induces allergic asthma desensitization via suppression of Tfh13 polarization
  • Abigail Pajulas, Indiana Univ. Sch. of Med., TH9-derived IL-9 promotes CCR2-dependent mast cell accumulation in the allergic lung
  • Ceire Hay, Perelman Sch. of Med., Univ. of Pennsylvania, Interrogating mechanisms of CD8 T cell dysfunction in obese asthma
  • Lars P. Lunding, Res. Ctr. Borstel, The NLRP3 Inflammasome Inhibitor OLT1177® Ameliorates Experimental Allergic Asthma in Mice
 Saturday, May 7, 2022     3:45 PM – 5:45 PM     Room B110–112

Autoantigen Identification, Autoantigen Specificity, and Central Tolerance

Chairs

  • Maria Bettini, Univ. of Utah Sch. of Med.
  • Kristin Hogquist, Univ. of Minnesota

Speakers

  • Mekha A. Thomas, Johns Hopkins Univ. Sch. of Med., The monocyte cell surface as a novel site of autoantigen generation in Rheumatoid Arthritis
  • Mianmian Yin, Univ. of California, San Francisco, Autoantigen specific T-cell receptor induces organ-specific autoimmunity by escaping T cell negative selection
  • Alexander J. Dwyer, Univ. of Minnesota, CD4+ T cells targeting a hybrid insulin: chromogranin A self-antigen are necessary and sufficient for autoimmune diabetes initiation
  • Yi Jing, Baylor Col. of Med., Insulin specific TCR repertoire analysis reveals functional diversity of Treg TCRs
  • Paul Zdinak, Univ. of Pittsburgh Sch. of Med., Profiling transcriptomes, TCR repertoires, and antigenic specificities of islet-infiltrating T cells in non-obese diabetic mice
  • Jun Hyung Sin, Univ. of California, San Francisco, Control of medullary thymic epithelial cell development and central tolerance by a zinc finger transcription factor
  • Ryan J. Martinez, Univ. of Minnesota, Type III interferon enhances thymic B cell licensing
  • Gregory J. Tsay, China Med. Univ., A specific 25-mer peptide from the cysteine protease of P. gingivalis is the epitope of humoral immune response in rheumatoid arthritis
 Saturday, May 7, 2022     3:45 PM – 5:45 PM     Room B117–119

B and T Cell Development

Chairs

  • Ann Griffith, Univ. of Texas Hlth. Sci. Ctr. San Antonio
  • Neetu Gupta, Cleveland Clin.

Speakers

  • Sarah A. Wedemeyer, Univ. of Texas Hlth. Sci. Ctr. at San Antonio, Role of paracrine mTOR signaling in regulating thymus size and function
  • Katherine Maude Ashby, Univ. of Minnesota, Thymic interferon impacts T cell selection
  • Tom N. Taghon, Ghent Univ., Belgium, An unexpected role for IRF8 during human T cell development
  • Breanna P. Caruso, Oregon Hlth. & Sci. Univ., A lineage specific role for PD-1 in agonist selection in the thymus
  • Jonathan E. Boyson, Univ. of Vermont, Single-cell proteogenomics reveals that SLAM/SAP signaling regulates the development of innate-like γδ T cell subsets with distinct TCR repertoires
  • Varun Aysola, Cleveland Clin., Ezrin promotes antigen receptor diversity during B cell development by supporting immunoglobulin heavy chain variable gene recombination
  • Michael Jonathan Lehrke, Mayo Clin., ABCB7 is required for B cell development, proliferation, and class switch recombination
 Saturday, May 7, 2022     3:45 PM – 5:45 PM     Room A105–106

Molecular, Metabolic, and Epigenetic Regulation of Innate Immunity and Inflammation

Chairs

  • Connie Krawczyk, Van Andel Inst.
  • Sarah Ewald, Univ. of Virginia

Speakers

  • Chao Yang, Hosp. for Special Surgery, Costimulation of TLR8 responses by CXCL4 in human monocytes mediated by TBK1-IRF5 signaling and epigenomic remodeling
  • Matthew D. Woolard, Louisiana State Univ. Hlth. Sciences Ctr. at Shreveport, Lipin-1 integrates lipid metabolism with macrophage function to promote inflammation resolution
  • David Orlando Diaz-Jimenez, NIEHS, NIH, Glucocorticoids suppress NLRP3 Inflammasome activation through transcriptional metabolic reprogramming of IRG-1/ACOD1 in macrophages
  • Raza Ali Naqvi, Univ. of Illinois at Chicago, Modulation of myeloid cell functions by long noncoding RNAs RN7SK and HCG11
  • Alicer Keendalyn Andrew, Univ. of Georgia, Relationships between inflammation, coagulation, and oxidative stress in malaria-induced pregnancy compromise
  • Abhimanyu Abhimanyu, Baylor Col. of Med., Targeting TCA cycle metabolites by small molecule inhibitors ameliorate LPS induced immune tolerance in Macrophages through epigenetic mechanisms
  • Katherine E. Lothstein, Rutgers Univ. New Jersey Med. Sch., Helminth TGF-β mimic, TGM, increases leukocyte migration and activation while also enhancing cutaneous wound healing and tissue regeneration
 Saturday, May 7, 2022     3:45 PM – 5:45 PM     Oregon Ballroom 201

Overcoming Current Roadblocks in CAR T Cell Therapy

Chair

  • Anna Halling Folkmar Andersen, New York Univ. Langone Med. Center

Speakers

  • Monika Kizerwetter, Johns Hopkins Univ., Anti-CD123 chimeric antigen receptor natural killer cell therapy to treat acute myeloid leukemia
  • Nicholas R. J. Gascoigne, Natl. Univ. of Singapore, Utilizing distinct CAR and TCR signaling to generate enhanced cellular immunotherapy
  • Daniel S. Wilkinson, Duke Univ. Med. Ctr., D2C7 CAR: A novel CAR T cell that simultaneously targets wildtype EGFR and its mutant isoform EGFRvIII for treatment of glioma
  • Jillian Baker, Univ. of Maryland Sch. of Med., Engineering anti-CD229 CAR T cell selectivity for multiple myeloma
  • Xander Gordon Ray Bradeen, Univ. of Colorado Anschutz Med. Campus, Identifying novel epigenetic modifiers that sensitize T cell malignancies to CD8+ T cell mediated cytotoxicity by high throughput drug screen
  • Royce Ma, Baylor Col. of Med., T cells resist CD5 CAR mediated fratricide by continuously degrading CD5 protein
  • Caitlin C. Zebley, St. Jude Children's Res. Hosp., CD19-CAR T cells develop exhaustion epigenetic programs during a clinical response
  • Nayan Jain, Mem. Sloan Kettering Cancer Ctr., SUV39H1 disruption imparts functional persistence to CD28-costimulated human CAR T cells