IMMUNOLOGY2022™

May 6–10, 2022 | Portland, Oregon

Blocks Sunday, May 8, 2022

Block Symposia

Full Listing
Fri. May 6
Sat. May 7
Sun. May 8
Mon. May 9
Tue. May 10

Sunday, May 8, 2022

 Sunday, May 8, 2022     8:00 AM – 10:00 AM     Oregon Ballroom 202

B Cell and T Cell Helper Responses during Viral Infections

Chairs

  • Akiko Iwasaki, Yale Sch. of Med.
  • Henrique Borges da Silva, Mayo Clin.

Speakers

  • Henrique Borges da Silva, Mayo Clin., Establishment of influenza-specific lung tissue-resident helper memory CD4+ T cells relies on expression the eATP sensor P2RX7
  • E. Taylor Stone, St. Louis Univ, Sch. of Med., Requirement for robust T and B cell responses for immune protection against Powassan virus (POWV) in virus-like particle (VLP) vaccination
  • Christopher Ned Jondle, Med. Col. of Wisconsin, T cell-intrinsic IL-17RA signaling in the spleen supports the establishment of chronic gammaherpesvirus infection
  • Yexin Yang, Yale Sch. of Med., Glycan-specific B-1 cells mediate blockade of endogenous retroviruses emergence through recognition of conserved glycan epitopes
  • Antonio Cembellin Prieto, Univ. of California, Davis, B cell-derived acetylcholine controls local inflammation and replication of influenza virus during respiratory tract infections
  • Jalene V. Velazquez, Washington State Univ., Distinct antibody profiles against Ebola virus track with the development of Post-Ebola Syndrome.
  • Ariana Denise Campbell, Johns Hopkins Bloomberg Sch. of Public Hlth., Influenza A virus-specific maternal antibodies impair vaccine-induced antibody responses and protection in male to a greater extent than female offspring
  • Jenna Guthmiller, Univ. of Chicago, B cell convergence to distinct broadly reactive epitopes revealed by chimeric hemagglutinin vaccination
 Sunday, May 8, 2022     8:00 AM – 10:00 AM     Room B113–116

Big Data: The Key to Unlocking Immune Mediated Mechanisms of Tumor Progression and Therapy Response

Chairs

  • Mary Philip, Vanderbilt Univ. Med. Ctr.
  • Sepideh Dolatshahi, Univ. of Virginia

Speakers

  • Joshua Brand, Univ. of Wisconsin-Madison, Single-cell myeloid diversity in human fallopian tube and its implications for early high grade serous ovarian cancer
  • Nicola S. Meagher, Univ. of New South Wales, Multi-modal immune profiling of mucinous ovarian carcinoma: analysis from the Ovarian Tumor Tissue Analysis/Multidisciplinary Ovarian Cancer Outcomes Group consortia
  • Mieszko Lachota, Med. Univ. of Warsaw, Analysis of chemokine network in primary human glioblastoma
  • Cristina F. Contreras, NCI, NIH, Transcriptomic and epigenetic profiling of tumor-associated monocyte function
  • Huy Dinh, Univ. of Wisconsin-Madison, Defining myeloid plasticity and heterogeneity in immunotherapy response
  • Vivien Ileana Maltez, NIAID, NIH, Multiplex microscopy reveals unique spatiotemporal effects of cancer immunotherapies
  • William L. Redmond, Earle A. Chiles Res. Inst., Multimodal single-cell analysis of human TILs across multiple tumor types reveals heterogeneity and potential opportunities for personalized immunotherapy
  • Abigail L. Sedlacek, Univ. of Pittsburgh, Identification of immunogenic peptide neoantigens expressed in sarcomas and their therapeutic potential
 Sunday, May 8, 2022     8:00 AM – 10:00 AM     Oregon Ballroom 201

Infection and Disease

Chairs

  • Marta Catalfamo, Georgetown Univ. Sch. of Med.
  • Bethany Mundy-Bosse, The Ohio State Univ. Col. of Med.

Speakers

  • Tanya Novak, Boston Children's Hosp. and Harvard Med. Sch., Genes associated with multiple organ dysfunction syndrome during severe pediatric influenza
  • Julie G. Burel, La Jolla Inst. for Immunology, Profiling the myeloid compartment of PBMC in active tuberculosis reveals substantial changes in CD14+ cells and upregulation of CD16 in pro-inflammatory dendritic cells
  • Jeffrey Alan Tomalka, Emory Univ. Sch. of Med., Inflammasomes and IL-1β: an innate immune axis in CD4+ T cells driving HIV infection and disease progression
  • Hadas Tamar Pahima, Hebrew Univ. of Jerusalem, COVID-19 patients are characterized by increased levels of immune cell membrane-bound and soluble CD48
  • Sarah C. Glover, Univ. of Mississippi Med. Ctr., Circulating extracellular vesicles from patients with severe COVID-19 upregulate Cathepsin B and activate STAT3 in normal human mesangial cells
  • Josh S. Mytych, Oklahoma Med. Res. Fndn., Bacillus anthracis peptidoglycan alters human M2-like macrophage phenotype and efferocytic function in the presence of human serum
  • Ismaila L. Manneh, London Sch. of Hygiene and Tropical Med., Targeted transcriptomic signature for monitoring anti-tuberculosis treatment response
  • Yashoda Madaiah Hosakote, Univ. of Texas Med. Br. at Galveston, SARS-CoV-2 induced oxidative stress promotes HMGB1 secretion to induce inflammation
 Sunday, May 8, 2022     8:00 AM – 10:00 AM     Room B117–119

Molecular Mechanisms of Inflammation

Chairs

  • Kristin Patrick, Texas A&M Univ., Col. of Med.
  • Brooke Napier, Portland State Univ.

Speakers

  • Haley M. Scott, Texas A&M Hlth. Sci. Ctr., Serine Arginine Splicing Factor 7 (SRSF7) is a critical regulator of innate immune activation in macrophages
  • Stephanie R. Shames, Kansas State Univ., Effector-mediated subversion of proteasome activator (PA)28αβ enhances lysosomal pathogen targeting within cytokine-activated macrophages
  • James Robert Fisher, Univ. of Texas Med. Br. at Galveston, Mincle and TNF signaling crosstalk enhances type 1 and innate immune responses to Orientia tsutsugamushi
  • Antonio J. Pagán, Univ. of Cambridge, mTOR-associated mitochondrial energy metabolism limits mycobacterium ESX-1-induced cytotoxicity
  • Amy Lorraine Seufert, Portland State Univ., Palmitic acid reprograms inflammatory responses to microbial ligands in macrophages, and mediates innate immune memory in vivo
  • Haleigh Gilliland, Michigan State Univ., Defining complex mechanistic interactions and responses by macrophages during Mycobacterium abscessus infection
  • Cheyenne Palm, Towson Univ., NADase activity found in bacterial TIR proteins may aid in innate immune evasion
  • Michal Caspi Tal, Stanford Univ. Sch. of Med., P66 is a bacterial "don't eat me signal" that mimics mammalian CD47 and facilitates immune evasion by Borrelia burgdorferi
 Sunday, May 8, 2022     8:00 AM – 8:00 AM     Room A105–106

Mucosal Innate Immune Cells

Chairs

  • Andea Reboldi, Univ. of Massachusetts Med. Sch.
  • Paige Porrett, Univ. of Alabama at Birmingham Sch. of Med.

Speakers

  • Wan-Jung Wu, Mem. Sloan Kettering Cancer Ctr., Select mucosa-associated intestinal commensal bacteria promote gut barrier repair by inducing IL-1b production
  • Michela Frascoli, Univ. of Massachusetts Med. Sch., Crosstalk between skin homing innate T cells and epithelial cells via cholesterol byproduct messengers is required for tissue immunity
  • Jia Nie, NCI, NIH, The transcription factor LRF promotes Integrin β7 expression by and gut homing of CD8αα intraepithelial lymphocyte precursors
  • Xuqiu Lei, Univ. of Massachusetts Chan Med. Sch., Epithelial HNF4A shapes the intraepithelial lymphocyte compartment via direct regulation of immune signaling molecules
  • Angeline Chen, La Jolla Inst. for Immunology, Small intestine epithelial CD4 cytotoxic T lymphocytes provide innate-like protection against enteric pathogens without risk of immunopathology
  • Paige Porrett, Univ. of Alabama at Birmingham Sch. of Med., Aberrant survival of uterine natural killer subsets in uterus transplant recipients
  • Thanh Thanh Trinh Dinh, The Ohio State Univ. Col. of Med., ILC3 expansion in acute myeloid leukemia
 Sunday, May 8, 2022     8:00 AM – 10:00 AM     Room C123–124

T Cell Effector Generation and Function

Chairs

  • Takeshi Egawa, Washington Univ. Sch. of Med.
  • Sarah Hamilton, Univ. of Minnesota

Speakers

  • Anna Halling Folkmar Andersen, Aarhus Univ., Single-cell TCR and mRNA sequencing of antigen-specific T cells reveal spatial trajectories from single time points with HLA and VDJ bias
  • Ao Guo, St. Jude Children's Res. Hosp., The SWI/SNF canonical BAF complex and c-Myc cooperate to promote early fate decisions in CD8+ T cells
  • Jessica A. Gaevert, St. Jude Children's Res. Hosp., Characterization of the cross-reactive T cell repertoire in the context of heterosubtypic influenza A virus infection
  • Erin D. Lucas, Univ. of Minnesota, Expansion and maintenance of long lived effector CD8 T cells is modulated by inflammation
  • Yu Xia, Washington Univ. in St Louis Sch. of Med., BCL6-dependent TCF-1+ progenitor cells maintain effector and helper CD4 T cell responses to persistent antigen
  • Mirela Kuka, Università Vita Salute San Raffaele, A fluorescent reporter model to study the role of TDC during infection and cancer
 Sunday, May 8, 2022     10:15 AM – 12:15 PM     Oregon Ballroom 201

Primary Immune Deficiency and Immune Dysregulation

Chairs

  • Emily M. Mace, Columbia Univ.
  • Elissa Deenick, Garvan Inst. of Med. Res.

Speakers

  • Ruth J. Napier, Oregon Hlth. and Sci. Univ., T cell intrinsic role for NOD2 in Blau Syndrome
  • Marita Bosticardo, NIAID, NIH, Characterization of thymic epithelial cell and thymocyte function and development in patients with thymic defects using scRNAseq profiling
  • Zinan Zhang, Harvard Med. Sch., Bi-allelic TTC21A mutations in common variable immunodeficiency patients
  • Sukalp Muzumdar, Cold Spring Harbor Lab., A granular view of X-linked chronic granulomatous disease exploiting single-cell transcriptomics
  • Julia Bier, Garvan Inst. of Med. Res., Australia, T cell extrinsic mechanics explaining the T cell hyperactivation seen in Activated PI3K δ Syndrome
  • Nicolai S. van Oers, Univ. of Texas Southwestern Med. Ctr., 22q11.2 deletion syndrome causes a thymus hypoplasia corrected by mesenchymal cell replacement
  • Olivia Bailey, Univ. of Colorado Anschutz Med. Campus, Dissecting the effect of a novel hypomorphic IL2RB mutation on immune dysregulation
  • Jose S. Campos Duran, Perelman Sch. of Med., Univ. of Pennsylvania, Dysregulation of CD8+ T cell function in the setting of altered cytokine signaling due to inborn errors of immunity
 Sunday, May 8, 2022     10:15 AM – 12:15 PM     Oregon Ballroom 204

Technological Innovations in Immunology II

Chairs

  • Amanda M. Burkhardt, Univ. of Southern California
  • Yuri Sykulev, Thomas Jefferson Univ.

Speakers

  • Joseph Cornelius Lownik, Cedars Sinai Med. Ctr., Expanding the use of clustering and dimensionality reduction in high parameter flow cytometry data through machine learning for novel samples
  • Vaishnavi Kaipilyawar, Rutgers New Jersey Med. Sch., Derivation of a parsimonious Tuberculosis gene signature using the digital NanoString nCounter platform
  • Lanaiah M. Ieremia, Texas Tech Univ. Hlth. Sci. Ctr. El Paso, Host-targeted self-attenuated influenza virus as a potential therapeutic influenza vaccine
  • Shijie Cao, Univ. of Chicago, Lymph node-targeted long-acting butyrate micelles induce regulatory immune modulation
  • Sophia Liu, MIT, Spatially mapping T cell receptors and transcriptomes
  • Irene E. Whitney, Honeycomb Biotechnologies, HIVE Single-cell TCR sequencing: assay principle and applications
  • Sheila Burns, Applied Cells, Inc., A multi-physics approach for high recovery and purity isolation of plasma cells in whole blood
 Sunday, May 8, 2022     10:15 AM – 12:15 PM     Oregon Ballroom 202

Tissue-Resident Memory T Cells (Trm) in Cancer

Chairs

  • Jose R. Conejo-Garcia, H. Lee Moffitt Cancer Ctr. and Res. Inst.
  • Fathia Mami-Chouaib, INSERM U1186, France

Speakers

  • Hui Zhang, Washington State Univ., Tissue-resident memory CD4+ T cells play a dominant role in the initiation of antitumor immunity
  • Michael J. Gough, Providence Portland Med. Ctr., Tumor resident memory CD8 T cell formation and concomitant tumor immunity is CD40L dependent and CD4 independent
  • Nu Zhang, Univ. of Texas Hlth. Sci. Ctr. at San Antonio, TGF-β-dependent Lymphoid Tissue Residency of Stem-like T cells Limits the Response to Tumor Vaccine
  • Carmen Mariam Anadon Galindo, H. Lee Moffitt Cancer Ctr. and Res. Inst., Ovarian cancer immunogenicity is governed by a narrow subset of progenitor tissue-resident memory T-cells
  • Noah Veis Gavil, Univ. of Minnesota, Chronic antigen in solid tumors drives a distinct program of T cell residence
  • Fathia Mami-Chouaib, INSERM U1186, France, Resident memory T cells in antitumor immunity and cancer immunotherapy
 Sunday, May 8, 2022     12:30 PM – 2:30 PM     Room B113–116

The Impact of the Commensal Microbiome on Cancer Progression and Therapy Response

Chairs

  • Melanie R. Rutkowski, Univ. of Virginia
  • Irving Allen, Col. of Vet. Med.. Virginia Tech

Speakers

  • Kaiting Yang, Univ. of Chicago, Suppression of local IFN-I by commensal microbiota-derived butyrate impairs antitumor effects of ionizing radiation
  • Qingsheng Li, Univ. of Louisville, Dietary low-fiber promotes resistance to immune checkpoint inhibitor immunotherapy in the LSL-KrasG12D Lung Cancer Model
  • Romina E. Araya, NCI, NIH, Neutrophil dynamics in the tumor microenvironment determines therapy efficacy and is regulated by microbiota
  • Liangliang Wang, Univ. of Chicago, Lactobacillus rhamnosus GG re-shapes gut microbiota and triggers STING-type I IFN-dependent antitumor immunity
  • Mitchell Thomas McGinty, Univ. of Virginia, Absence of Toll-like receptor 5 confers survival in mice bearing ovarian tumors treated with anti-PD-L1
  • Qingsheng Li, Univ. of Louisville, Resistance to Anti-PD-1 Therapy is mediated via the Microbiota-Th17-Prostoglandin E2 Axis in the LSLKrasG12D Lung Cancer Model
  • Khiem C. Lam, NCI, NIH, Tumor-intrinsic factors dictate beneficial effect of microbiota-based therapies
 Sunday, May 8, 2022     12:30 PM – 2:30 PM     Oregon Ballroom 203

Innate Immunity to Viral Infection

Chairs

  • Paul Thomas, St. Jude Children's Res. Hosp.
  • Shitao Li, Tulane Univ. Sch. of Med.

Speakers

  • Yakun Wu, Tulane Univ. Sch. of Med., Nuclear soluble cGAS senses DNA virus infection
  • Murugesan Rajaram, Ohio State Univ., Influenza A virus modulates ACE2 expression and SARS-CoV-2 infectivity in human cardiomyocytes
  • Jenny Resiliac, Research Institute at Nationwide Children's Hospital, Lipopolysaccharide pre-treatment prevents viral induced death by priming macrophages for a robust anti-viral immune response
  • Yi Yao, Henry Ford Hlth. Sys., Circulating monocytes co-expressing surface ACE2 and TMPRSS2 upon TLR4/7/8 activation are susceptible to SARS-CoV-2 infection
  • Jennifer R. Connors, Drexel Univ. Col. of Med., The impact of lipid nanoparticles (LNP) on anti-viral pathways and immune function in aged individuals
  • Marissa Lindman, Rutgers Univ., Astrocytic RIPK3 confers protection against deleterious neuroinflammation during Zika virus infection
  • Anshu Agrawal, Univ. of California Irvine, Innate immune mechanisms underlying sex differences in COVID-19
 Sunday, May 8, 2022     12:30 PM – 2:30 PM     Room B110–112

Innate Signaling, Microbiome, and Metabolism in Autoimmunity

Chairs

  • Leah Kottyan, Cincinnati Children's Med. Ctr.
  • Betsy Barnes, The Feinstein Inst. for Med. Res., Northwell Hlth.

Speakers

  • Bharati Matta, Feinstein Inst. for Med. Res., IRF5 risk variants contribute to pre-symptomatic SLE by enhancing the levels of circulating NET antigens
  • Morgan Lee Terrell, Univ. of Florida, Treatment with TLR7/8 agonist compromises intestinal epithelium integrity in a lupus prone mouse model
  • Kevin MingJie Gao, Univ. of Massachusetts Med. Sch., Radioresistant cells in STING gain-of-function mice initiate lymphocyte dependent lung inflammation and IFNγ dependent mortality
  • David Nemazee, Scripps Res. Inst., Cleavage of DNA and RNA by PLD3 and PLD4 limits autoinflammatory triggering by multiple sensors, including endolysosomal TLRs and a STING dependent sensing pathway
  • Mitra Padideh Maz, Univ. of Michigan, Understanding innate immune cell-mediated inflammation in UV-induced skin injury in lupus-prone mice
  • William J. Turbitt, Univ. of Alabama at Birmingham, Neutrophil-specific Socs3 deficiency induces brain-targeted experimental autoimmune encephalomyelitis with enhanced cerebellar neutrophil activation
  • Shailesh K. Shahi, Univ. of Iowa, HLA Class II polymorphisms influence gut microbiota composition and modulate disease in transgenic mice model of multiple sclerosis
  • Mary A. Markiewicz, Univ. of Kansas Med. Ctr., The role of NKG2D signaling in NOD diabetes is affected by the microbiota
 Sunday, May 8, 2022     12:30 PM – 2:30 PM     Room B117–119

Neuronal and Central Nervous System Immunity

Chair

  • Aaron Johnson, Mayo Clin. Rochester

Speakers

  • Arya Biragyn, NIA, NIH, A surprising pathogenic role of B cells in mice with Alzheimer's disease
  • Pooja Jain, Drexel Univ. Col. of Med., Nutraceutical Apigenin regulates DC function in a RelB-dependent manner during neuroinflammation
  • Zhangying Chen, Feinberg Sch. of Med., Northwestern Univ., T-cell infiltrates and microglia adopt long-term gene signature changes leading to age-specific responses to traumatic brain injury in mice
  • Ling Cao, Univ. of New England, Responses of injured nerve in CD137L knockout mice following sciatic nerve crush-induced neuropathic pain
  • Murugaiyan Gopal, Brigham and Women's Hosp. and Harvard Med. Sch., MicroRNA control of inflammatory and regulatory T cells in CNS autoimmunity
  • Ling Cao, Univ. of New England, Electromyographic characterization and bioinformatic pathway analysis of spinal cord inflammation in a Tat induced HIV-associated sensory neuropathy model
  • Yan Wang, Thomas Jefferson Univ., Single-cell RNA sequence (scRNAseq) analysis of T regulatory cells in relapsing remitting multiple sclerosis (RRMS)
 Sunday, May 8, 2022     12:30 PM – 2:30 PM     Oregon Ballroom 202

Vaccines and Immunity against Bacteria and Parasites

Chairs

  • JoAnne L. Flynn, Univ. of Pittsburgh Sch. of Med.
  • David A. Rosen, Washington Univ. Sch. of Med.

Speakers

  • Yanli Li, Univ. of North Carolina at Chapel Hill, Identification of CPAF as the immunoprevalent antigen of Chlamydia trachomatis
  • Jaikin Harrell, Tulane Univ. Sch. of Med., The use of outer membrane vesicles as novel, mucosal adjuvants against intracellular bactiera
  • Matthew Bell, Drexel Univ. Col. of Med., The novel adjuvant, ADA-1, restores age-associated defects in the adaptive immune response to Clostridioides difficile infection and vaccination in an aging mouse model
  • Valery Cristina Román-Cruz, Univ. of Montana, Adjuvanted multivalent vaccine targeting clinically relevant Pf bacteriophage creates cross-reactive antibodies
  • Paeton L. Wantuch, Washington Univ. Sch. of Med., Differential Immune Response to Klebsiella pneumoniae O-antigen subtypes O2v1 and O2v2
  • Andrew W. Simonson, Univ. of Pittsburgh Sch. of Med., The role of lymphocyte subsets in preventing tuberculosis following intravenous vaccination with BCG
  • Eva Morgun, Feinberg Sch. of Med., Northwestern Univ., Mycolic acid nanoparticle vaccination leads to antigen persistence and unique differentiation of mycobacterial lipid antigen-specific T cells
  • Caroline J. Duncombe, Univ. of Washington, Differential sex-specific immune responses following Prime-and-Trap vaccination alters protection against malaria in mice
 Sunday, May 8, 2022     3:45 PM – 5:45 PM     Room A105–106

CD4+ T Cells in Cancer

Chairs

  • Stephen Schoenberger, La Jolla Inst. for Immunology
  • Steven Ziegler, Benaroya Res. Inst.

Speakers

  • Spencer E. Brightman, La Jolla Inst. for Immunology, TCR-engineered neoantigen-specific CD4+ T cells mediate immunotherapy of a class II-negative murine squamous cell carcinoma
  • Katelyn T. Byrne, Perelman Sch. of Med., Univ. of Pennsylvania, CD4+ T cells mediate non-canonical rejection of major histocompatibility class-I deficient pancreatic tumors independently of CD8+ T cells
  • Dan Chen, Salk Inst. for Biological Studies, Dissecting anti-tumor immunity in glioblastoma
  • Ying Zheng, Johns Hopkins Univ. Sch. of Med., Target the activin receptor 1c on CD4+ T cells to achieve anti-tumor therapeutic effects
  • Hsin Yu Liu, La Jolla Inst. for Immunology, Leveraging the Treg-intrinsic CTLA4-PKCη signaling pathway for cancer immunotherapy
  • Kazushige Obata-Ninomiya, Benaroya Res. Inst., Virginia Mason, Thymic stromal lymphopoietin (TSLP) receptor signaling controls a tumorigenic Treg to promote colorectal cancer
  • Kai Yang, Indiana Univ. Sch. of Med., The glutathione peroxidase Gpx4 prevents Treg lipid peroxidation and ferroptosis to facilitate tumor immunoevasion
 Sunday, May 8, 2022     3:45 PM – 5:45 PM     Oregon Ballroom 201

CD8+ T Cell Immunity to Viral Infections

Chairs

  • Benjamin Youngblood, Saint Jude Children's Res. Hosp.
  • Erietta Stelekati, Miller Sch. of Med., Univ. of Miami

Speakers

  • Blair K. Hardman, Univ. of British Columbia, Differential localization and kinetics of antiviral CD8+ T cell responses to chronic and acute murine norovirus infections from initiation onwards
  • Jia Zhu, Univ. of Washington, In situ characterization of lesion-forming human HSV-2 reactivation reveals distinct innate and adaptive immune compartmentalization
  • Adolfo B. Frias, St. Jude Children's Res. Hosp., HIV-specific CD8+ T cells from elite controllers have an epigenetic imprint that preserves effector functions
  • Blake Torrance, UConn Hlth., Role of p16 expressing cells in formation and function of T cell memory with age
  • Xuebing Leng, Miller Sch. of Med., Univ. of Miami, MicroRNA-29a attenuates exhaustion and promotes memory-like CD8+ T cells
  • Genevieve N. Mullins, Univ. of North Carolina at Chapel Hill, CD8+ T cell exhaustion is dynamically controlled by the chromatin regulator factor BRD4
  • Roman Khadka, Mayo Clin., A novel approach to define contribution of microglia and brain endothelium in antigen specific CD8+ T cell-mediated blood brain barrier (BBB) disruption during virus infection
  • Jennifer Berger, Univ. of Colorado Anschutz Med. Campus, A unique gammadelta T cell population in the brain during viral infection
 Sunday, May 8, 2022     3:45 PM – 5:45 PM     Oregon Ballroom 202

Therapies for Rheumatic Diseases and Beyond

Chairs

  • Randy S. Longman, Weill Cornell Med.
  • Laurence M. Morel, Univ. of Florida Col. of Med.

Speakers

  • Rinkesh Kumar Gupta, La Jolla Inst. for Immunology, Therapeutic targeting of tumor necrosis factor like weak inducer of apoptosis (TWEAK) in psoriasis
  • Yogesh Scindia, Univ. of Florida, Renal tubular cell ferroptosis: a new player in pathogenesis of lupus nephritis
  • Ahmed Samir Elshikha, Univ. of Florida, The gut microbiota transfers the therapeutic effect of inhibiting glucose metabolism in lupus-prone mice
  • Svetlana Ferreira Lima, Weill Cornell Med., Defining the role for the gut microbiome in the clinical efficacy of sulfasalazine therapy for IBD associated spondyloarthritis
  • Longhuan Ma, Univ. of Florida, A combination of genetic factors and dietary tryptophan shapes gut microbial dysbiosis in a lupus-prone mouse model
  • Laura Santambrogio, Weill Cornell Med., Characterization of a novel anti-inflammatory biogenic amine
  • Hu Zeng, Mayo Clin. Rochester, The immune dysregulations in inflammatory arthritis immune related adverse events
  • Justin Choe, Mayo Clin. Grad. Sch. of BioMed. Sci., ST8Sia6 expression in beta cells mitigates onset of autoimmune diabetes in the murine NOD model
 Sunday, May 8, 2022     3:45 PM – 5:45 PM     Oregon Ballroom 203

Transplant Immunology: Novel Mechanisms and Interventions

Chairs

  • Giorgio Raimondi, Johns Hopkins Univ. Sch. of Med.
  • Maria-Luisa Alegre, Univ. of Chicago

Speakers

  • Gavin I. Ellis, Univ. of Pennsylvania, Alloantigen-specific Chimeric Antigen Receptor Regulatory T cell therapy in non-human primate islet transplantation
  • Feiyan Mo, Baylor Col. of Med., Engineering T cells to prevent graft-versus-host disease and leukemia relapse following allogeneic stem cell transplantation
  • Caroline Anna Markmann, Perelman Sch. of Med., Univ. of Pennsylvania, Leveraging CAR T cells to achieve desensitization and enable transplantation
  • Jordan Warunek, Univ. of Pittsburgh Sch. of Med., Paired immunoglobulin-like receptors impact the differentiation of reparative macrophages following allogeneic challenge
  • Fathima A. Mohamed, Univ. of Minnesota, Targeting temporal metabolic needs of T follicular helper cells to treat cGVHD utilizing a mitochondrial pyruvate carrier inhibitor
  • Michael Nicosia, Cleveland Clin. Fndn., The role of LAG3 in antibody responses to kidney transplantation
  • Peter Wang, Univ. of Chicago, Oral alloantigen exposure promotes donor-specific tolerance in a mouse model of minor mismatched skin transplantation
  • Jared Pollard, Univ. of Chicago, Graft-matched pregnancy imparts profound epigenetic changes onto alloreactive memory t cells to enforce a phenotypic and transcriptional state of tolerance
 Sunday, May 8, 2022     3:45 PM – 5:45 PM     Room B113–116

Tumor Microenvironment (TME) I

Chair

  • Dorina Avram, H. Lee Moffitt Cancer Ctr. and Res. Inst.

Speakers

  • Gunjan Mandal, H. Lee Moffitt Cancer Ctr. and Res. Inst., Spontaneous class-switched antibody responses at endometrial cancer tumor bed drives superior patients' outcome
  • Zihan Guo, Oregon Hlth. and Sci. Univ., Class switching is required for antigen-dependent b cell anti-tumor activity
  • Zhi-Zhang Yang, Mayo Clin., T-cell phenotype varies in distinct tumor microenvironments and CD57+ TFH cells are associated with disease progression and inferior survival in follicular lymphoma
  • Juyeun Lee, Cleveland Clin. Fndn., Sex-specific T cell behavior drives differential immune responses in mouse glioblastoma models
  • Stephanie Gomez, George Washington Univ., Inhibition of DNMTs and RNA editing increases immunogenic transposable element RNA to reduce tumor burden and prolong survival in a murine ovarian cancer model
  • Tahereh Ziglari, Oregon Hlth. and Sci. Univ., Senescent cell-derived extracellular vesicles are critical elements in senescence surveillance by recruiting antigen-presenting cells
  • Thejaswini Giridharan, Roswell Park Comprehensive Cancer Ctr., Role of the extracellular ATP/adenosine pathway in neutrophil-mediated T cell suppression in ovarian cancer microenvironment
 Sunday, May 8, 2022     3:45 PM – 5:45 PM     Oregon Ballroom 204

Vaccination and Immunotherapy against COVID-19

Chairs

  • Donna L. Farber, Columbia Univ. Med. Ctr.
  • James J. Kobie, Univ. of Alabama at Birmingham

Speakers

  • Ebony Nicole Gary, Wistar Inst., Peripheral co-immunization with CCL27 drives robust mucosal responses to SARS-CoV-2 synDNA antigens and provides heterologous protection against Delta variant challenge
  • Vanessa S. Moraes, Univ. of Georgia, Polyfunctionality of T cell immunity in pre-immune and naïve individuals after COVID-19 mRNA vaccination
  • Elizabeth A. Thompson, Johns Hopkins Univ. Sch. of Med., Alternative lineage B cells utilizing fatty acid oxidation predict response to third dose COVID vaccination in solid organ transplant recipients
  • James Kobie, Univ. of Alabama at Birmingham, Pan-coronavirus neutralizing S2 human monoclonal antibodies and utility of direct respiratory administration as combination therapy with S1 antibodies against SARS-CoV-2
  • Timothy A. Bates, Oregon Hlth. and Sci. Univ., Hybrid immunity and vaccine breakthrough lead to robust humoral response and antibodies that effectively neutralize SARS-CoV-2 variants
  • Eric S. Geanes, Children's Mercy Kansas City, Differences between autoantibodies induced by SARS-CoV-2 infection and Pfizer-BioNTech SARS-CoV-2 vaccination
  • Julia Davis-Porada, Columbia Univ. Med. Ctr., Persistence of immune memory to SARS-CoV-2 vaccine in lymphoid tissue
  • John D. Mountz, Univ. of Alabama at Birmingham, IL-4R blockade prevents a long term memory B cell response to COVID-19 vaccination